Stomatology ›› 2022, Vol. 42 ›› Issue (10): 932-937.doi: 10.13591/j.cnki.kqyx.2022.10.013

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Research progress of the relationship between periodontitis and adverse pregnancy outcomes

BAI Xue, GAO Jinhua, REN Xiuyun   

  1. Department of Periodontics, School of Stomatology and Stomatological Hospital, Shanxi Medical University, Taiyuan 030001,China
  • Revised:2022-03-31 Published:2022-10-28

Abstract: Periodontitis is a chronic inflammatory disease caused by periodontal pathogen infection, which is more likely to occur in pregnant women. Adverse pregnancy outcome is an important cause for perinatal death of newborn, which is affected by systemic inflammation. This paper expounds the correlation between periodontitis and adverse pregnancy outcomes, further explores its mechanism from aspects of vaginal infection, bacteremia, immune inflammation, and intestinal flora, and briefly describes host′s susceptibility to periodontitis and adverse pregnancy outcomes in genetic background, in order to provide theoretical guidance for the prevention of periodontal diseases in pregnancy and adverse pregnancy outcomes in clinical practice.

Key words: periodontitis, adverse pregnancy outcome, Porphyromonas gingivalis, mechanism

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