活性氧与Hippo通路交互作用介导细胞行为的研究进展

doi:10.13591/j.cnki.kqyx.2022.11.014

Abstract

Abstract: Hippo signaling pathway is highly conserved in diverse species. It can directly regulate the transcriptional expression of downstream proteins, or indirectly modulate cell proliferation and apoptosis through interaction with other signaling pathways. Reactive oxygen species (ROS), as an important signaling molecule of redox reaction, plays an important regulatory role in cell survival, apoptosis, autophagy and other biological processes. Most scholars suggest that oxidative stress is an important factor leading to a variety of diseases, while antioxidants are beneficial to health. Hippo pathway and ROS can mediate different biological effects through complex mutual regulation induced by various intermediate factors. In recent years, attention to the Hippo signaling pathway and oxidative stress increases gradually. In this paper, their different roles in apoptosis, autophagy, aging, distant metastasis of tumor cells are summarized. Meanwhile, intricated adjustment mechanisms of Hippo pathway and ROS through interaction with other signaling pathways are also identified. This review provides new thinking for scholars who follow the latest research in this field and plan to conduct further research.

Key words: Hippo signaling pathway, redox signaling, apoptosis, autophagy, metastasis

CLC Number:

YU Hui, WANG Haochen, HUANG Tianyu, MAN Yi, XIANG Lin. Progress of research on the interaction between reactive oxygen species and Hippo pathway in mediating cellular behavior[J]. Stomatology, 2022, 42(11): 1031-1035.

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Progress of research on the interaction between reactive oxygen species and Hippo pathway in mediating cellular behavior

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