WTAP在肿瘤中作用的研究进展

doi:10.13591/j.cnki.kqyx.2022.11.015

Abstract

Abstract: N⁶-methyladenosine is considered the most common transcript modification in eukaryotic messenger RNA. WTAP (Wilms' tumor 1-associating protein), as a regulatory subunit of m⁶A methyltransferases, combines with METTL3 and METTL14 into WMM complex, which catalyzes m⁶A. Accumulating evidence suggests that WTAP plays an important role in tumorigenesis and cancer progression by regulating RNA metabolism, and has a significant association with prognosis of several kinds of cancer. This review will focus on the biological function of WTAP and its role in cancer, as well as its feasibility as a potential target for tumor therapy.

Key words: WTAP, m⁶A, tumor

CLC Number:

R783.1

LIN Xuyang, HAN Xiao, ZHANG Chengwan, ZHANG Shuangyue. Progress of research on the role of WTAP in tumor[J]. Stomatology, 2022, 42(11): 1036-1041.

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Progress of research on the role of WTAP in tumor

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