糖尿病影响牙周炎患者口腔龈下菌群和唾液菌群组成的研究进展

doi:10.13591/j.cnki.kqyx.2024.06.011

Abstract

Abstract:

In previous studies, the two-way relationship between periodontitis and diabetes has been established. Subgingival flora and salivary flora are often used to explore the relationship between the microbiome in diabetes and periodontitis. In recent years, the development of sequencing technology has provided a broader and deeper approach to exploring the impact of diabetes on oral microbiome. This review aims to summarize the effects of diabetes on subgingival flora and salivary flora in patients with periodontitis, so as to provide reference for clinical diagnosis and treatment.

Key words: periodontitis, diabetes mellitus, subgingival flora, salivary flora, sequencing technology

CLC Number:

R781.4

LIN Renjie, DAI Anna, WANG Shuhua, DING Peihui. Research progress of the influence of diabetes mellitus on subgingival and salivary flora with periodontitis[J]. Stomatology, 2024, 44(6): 458-461.

References 36

[1]	Pirih FQ, Monajemzadeh S, Singh N, et al. Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome[J]. Periodontol 2000, 2021, 87(1):50-75.
[2]	Sun XY, Li MH, Xia L, et al. Alteration of salivary microbiome in periodontitis with or without type-2 diabetes mellitus and metformin treatment[J]. Sci Rep, 2020, 10(1):15363. doi: 10.1038/s41598-020-72035-1 pmid: 32958790
[3]	Sanz M, Ceriello A, Buysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology[J]. J Clin Periodontol, 2018, 45(2):138-149. doi: 10.1111/jcpe.12808 pmid: 29280174
[4]	Griffen AL, Beall CJ, Campbell JH, et al. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing[J]. ISME J, 2012, 6(6):1176-1185. doi: 10.1038/ismej.2011.191 pmid: 22170420
[5]	Li C, Liu JB, Tan LS, et al. The sociodemographic characteristics, periodontal health status, and subgingival microbiota of patients with chronic periodontitis and type 2 diabetes mellitus: A case-control study in a Chinese population[J]. J Periodontol, 2013, 84(8):1058-1066. doi: 10.1902/jop.2012.120282 pmid: 23030242
[6]	Wu CZ, Yuan YH, Liu HH, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus[J]. BMC Oral Health, 2020, 20(1):204.
[7]	Stöhr J, Barbaresko J, Neuenschwander M, et al. Bidirectional association between periodontal disease and diabetes mellitus: A systematic review and meta-analysis of cohort studies[J]. Sci Rep, 2021, 11(1):13686. doi: 10.1038/s41598-021-93062-6 pmid: 34211029
[8]	Falcao A, Bullón P. A review of the influence of periodontal treatment in systemic diseases[J]. Periodontol 2000, 2019, 79(1):117-128.
[9]	Ebersole JL, Holt SC, Hansard R, et al. Microbiologic and immunologic characteristics of periodontal disease in Hispanic Americans with type 2 diabetes[J]. J Periodontol, 2008, 79(4):637-646. doi: 10.1902/jop.2008.070455 pmid: 18380556
[10]	Teles F, Wang Y, Hajishengallis G, et al. Impact of systemic factors in shaping the periodontal microbiome[J]. Periodontol 2000, 2021, 85(1):126-160.
[11]	de Araújo Silva DN, Casarin M, Monajemzadeh S, et al. The microbiome in periodontitis and diabetes[J]. Front Oral Health, 2022, 3: 859209.
[12]	Lu CT, Zhao QT, Deng JW, et al. Salivary microbiome profile of diabetes and periodontitis in a Chinese population[J]. Front Cell Infect Microbiol, 2022, 12: 933833.
[13]	段胜仲. 牙周微生态与心脑血管疾病研究进展[J]. 口腔医学, 2021, 41(7):577-582.
[14]	丁一, 王琪. 伴糖尿病牙周炎的治疗进展[J]. 口腔疾病防治, 2018, 26(9):545-550. doi: 10.12016/j.issn.2096-1456.2018.09.001
[15]	Jiang YL, Song BQ, Brandt BW, et al. Comparison of red-complex bacteria between saliva and subgingival plaque of periodontitis patients: A systematic review and meta-analysis[J]. Front Cell Infect Microbiol, 2021, 11: 727732.
[16]	Zhou M, Rong RC, Munro D, et al. Investigation of the effect of type 2 diabetes mellitus on subgingival plaque microbiota by high-throughput 16S rDNA pyrosequencing[J]. PLoS One, 2013, 8(4):e61516.
[17]	Lu HY, Zou PH, Zhang YF, et al. The sampling strategy of oral microbiome[J]. iMeta, 2022, 1(2):e23.
[18]	宋文静, 康文燕, 刘晓明, 等. 伴2型糖尿病牙周炎患者牙周基础治疗后口腔菌群的动态变化研究[J]. 中华口腔医学杂志, 2022, 57(6):585-594.
[19]	Farina R, Severi M, Carrieri A, et al. Whole metagenomic shotgun sequencing of the subgingival microbiome of diabetics and non-diabetics with different periodontal conditions[J]. Arch Oral Biol, 2019, 104: 13-23. doi: S0003-9969(19)30344-9 pmid: 31153098
[20]	Bachtiar BM, Theodorea CF, Tahapary DL, et al. A pilot study of red complex and three Genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform[J]. F1000 Research, 2021, 10: 79.
[21]	Ganesan SM, Joshi V, Fellows M, et al. A tale of two risks: Smoking, diabetes and the subgingival microbiome[J]. ISME J, 2017, 11(9):2075-2089. doi: 10.1038/ismej.2017.73 pmid: 28534880
[22]	Joaquim CR, Miranda TS, Marins LM, et al. The combined and individual impact of diabetes and smoking on key subgingival periodontal pathogens in patients with chronic periodontitis[J]. J Periodontal Res, 2018, 53(3):315-323. doi: 10.1111/jre.12516 pmid: 29110296
[23]	Wade WG. Resilience of the oral microbiome[J]. Periodontol 2000, 2021, 86(1):113-122.
[24]	Goodson JM, Hartman ML, Shi P, et al. The salivary microbiome is altered in the presence of a high salivary glucose concentration[J]. PLoS One, 2017, 12(3):e0170437.
[25]	Haffajee AD, Bogren A, Hasturk H, et al. Subgingival microbiota of chronic periodontitis subjects from different geographic locations[J]. J Clin Periodontol, 2004, 31(11):996-1002. doi: 10.1111/j.1600-051X.2004.00597.x pmid: 15491316
[26]	Da Cruz Galhardo Camargo GA, Silva NLC, et al. Periodontopathogens, Candida spp. and immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis[J]. Braz J Oral Sci, 2017, 15(3):226.
[27]	Rodríguez-Hernández AP, Márquez-Corona ML, Pontigo-Loyola AP, et al. Subgingival microbiota of mexicans with type 2 diabetes with different periodontal and metabolic conditions[J]. Int J Environ Res Public Health, 2019, 16(17):3184.
[28]	Preshaw PM, Taylor JJ, Jaedicke KM, et al. Treatment of periodontitis reduces systemic inflammation in type 2 diabetes[J]. J Clin Periodontol, 2020, 47(6):737-746. doi: 10.1111/jcpe.13274 pmid: 32106333
[29]	Matsha TE, Prince Y, Davids S, et al. Oral microbiome signatures in diabetes mellitus and periodontal disease[J]. J Dent Res, 2020, 99(6):658-665. doi: 10.1177/0022034520913818 pmid: 32298191
[30]	Longo PL, Dabdoub S, Kumar P, et al. Glycaemic status affects the subgingival microbiome of diabetic patients[J]. J Clin Periodontol, 2018, 45(8):932-940. doi: 10.1111/jcpe.12908 pmid: 29742293
[31]	Shi BC, Lux R, Klokkevold P, et al. The subgingival microbiome associated with periodontitis in type 2 diabetes mellitus[J]. ISME J, 2020, 14(2):519-530. doi: 10.1038/s41396-019-0544-3 pmid: 31673077
[32]	Belstrøm D. The salivary microbiota in health and disease[J]. J Oral Microbiol, 2020, 12(1):1723975.
[33]	Yang Y, Liu SL, Wang YH, et al. Changes of saliva microbiota in the onset and after the treatment of diabetes in patients with periodontitis[J]. Aging, 2020, 12(13):13090-13114.
[34]	Long J, Cai Q, Steinwandel M, et al. Association of oral microbiome with type 2 diabetes risk[J]. J Periodontal Res, 2017, 52(3):636-643. doi: 10.1111/jre.12432 pmid: 28177125
[35]	Sabharwal A, Ganley K, Miecznikowski JC, et al. The salivary microbiome of diabetic and non-diabetic adults with periodontal disease[J]. J Periodontol, 2019, 90(1):26-34. doi: 10.1002/JPER.18-0167 pmid: 29999529
[36]	Saeb ATM, Al-Rubeaan KA, Aldosary K, et al. Relative reduction of biological and phylogenetic diversity of the oral microbiota of diabetes and pre-diabetes patients[J]. Microb Pathog, 2019, 128: 215-229.

Research progress of the influence of diabetes mellitus on subgingival and salivary flora with periodontitis

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 36

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	HUANG Ailan, GUO Peipei, LU Xiaoqing, WU Jintao, LI Zehan, XU Xiuqing, WANG Juan, ZHOU Lili. Progress and prospects of dental pulp stem cells in diabetes treatment [J]. Stomatology, 2024, 44(6): 452-457.
[2]	WANG Ke, YOU Jing, LU Wei. Evaluation of the efficacy of selective curettage in endodontic microsurgery [J]. Stomatology, 2024, 44(5): 375-380.
[3]	WANG Xuekui, SUN Yao. Role of neutrophil in periodontitis: An updated review [J]. Stomatology, 2024, 44(4): 292-296.
[4]	ZHANG Zhihao, YANG Yi, WANG Yueqiu, SUN Siyi, CHEN Hong, SHU Fei, LIU Mei. Immune-related genes shared between Crohn's disease and periodontitis and their potential as diagnostic biomarkers [J]. Stomatology, 2024, 44(3): 184-191.
[5]	XIAO Shimeng, LIU Yi, LI Maoxue, DING Yi. Evaluation of the efficacy of laser-assisted non-surgical treatment of periodontitis with type 2 diabetes mellitus [J]. Stomatology, 2024, 44(3): 161-167.
[6]	ZHANG Jiaming, DUAN Yan, WU Yunxia. The role of reactive oxygen species and mitophagy in periodontitis [J]. Stomatology, 2024, 44(3): 237-240.
[7]	DAI Ke, DAI Zhouli, LIU Rongchang, ZHA Guangyu, CAO Mingguo. The role of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease [J]. Stomatology, 2024, 44(2): 152-155.
[8]	REN Jiayu, REN Xiuyun. Research progress of oxidative stress and antioxidant adjuvant therapy for periodontitis [J]. Stomatology, 2024, 44(2): 148-151.
[9]	ZHAO Mingyu, SHI Binmian, XIE Xudong, XU Chunmei, WANG Jun. Research progress of luteolin in the prevention and treatment for periodontitis [J]. Stomatology, 2024, 44(2): 126-129.
[10]	TANG Lu,XUE Dong,YANG Wenwen,ZHANG Xianli,LU Xia,ZHAO Ying. Distribution of periodontal pathogens in carotid atherosclerotic plaques with different degrees of carotid artery stenosis [J]. Stomatology, 2024, 44(1): 31-35.
[11]	GUO Yuanyuan, REN Jiayu, FENG Yongliang, REN Xiuyun. Correlation between the number of missing teeth and the degree of carotid atherosclerosis in type 2 diabetes mellitus patients [J]. Stomatology, 2023, 43(9): 791-795.
[12]	TANG Jinxin, TANG Chunbo, SONG Xin, RUI Na, XUE Chang'ao. Establishment of risk prediction model for peri-implantitis after dental implants in patients with periodontitis [J]. Stomatology, 2023, 43(8): 706-710.
[13]	ZHANG Min, MEI Youmin, YUAN Jianfen, SUN Jingwei, XU Jiali, YAN Junyi, LI Qiao, ZHOU Yan, SHEN Xiang. Correlation analysis between Helicobacter pylori infection and periodontitis in 127 cases [J]. Stomatology, 2023, 43(8): 702-705.
[14]	CAI Bobo, SI Misi. Research progress of immediate implant placement with fixed full-arch prosthesis in patients with severe periodontitis [J]. Stomatology, 2023, 43(7): 663-666.
[15]	LI Shaohua, LIN Xiaoping. Research progress of the relationship between periodontitis and non-alcoholic fatty liver disease [J]. Stomatology, 2023, 43(7): 652-656.