离子液体与口腔疾病防治研究进展

doi:10.13591/j.cnki.kqyx.2025.04.010

摘要/Abstract

摘要：

离子液体是具有较低的熔点和挥发性,较高溶解度的材料,可通过改变其化学结构来调控理化性质。此类材料可通过透皮给药、透黏膜给药和口服给药等方式发挥药理学作用,所以可作为载体用于药物递送,将药物成功递送至病灶部位。此外,离子液体本身也可具备抗菌和抗炎等特性,自身可作为药物发挥作用。根据以上特点,离子液体在口腔疾病防治领域也有较好的应用前景,目前已具有优化种植体、口腔抗菌材料、牙体修复和根管治疗等材料的功能,对手-足-口病和牙周炎等口腔疾病有较好的治疗效果,有望成为口腔疾病临床治疗策略。该文就离子液体的相关特性及其在常见口腔疾病中的应用进行综述,以期对疾病防治提供新的思路。

关键词: 离子液体, 抗菌, 抗炎, 口腔疾病

Abstract:

Ionic liquids are materials with a lower melting point and higher solubility that can be regulated by changing their chemical structure. These materials can play a pharmacological role through transdermal, transmucosal and oral administration, so they can be used as carriers for drug delivery and can successfully deliver drugs to the lesion site. In addition, the ionic liquid itself also has antibacterial and anti-inflammatory properties, and can act as a drug itself. According to the above characteristics, ionic liquid has application prospect in the field of oral disease prevention and treatment. At present, it has the function of optimizing implant, oral antibacterial material, dental prosthesis and root canal therapy, and has a good therapeutic effect on oral diseases such as hand-foot-mouth disease and periodontitis, and is expected to become a clinical treatment strategy for oral diseases. In this review, the properties of ionic liquids and their applications in common oral diseases are illustrated, in order to provide new ideas for oral disease prevention and treatment.

Key words: ionic liquid, anti-bacteria, anti-inflammation, oral disease

中图分类号:

R331.5

贾懿楠, 徐心源, 徐欣. 离子液体与口腔疾病防治研究进展[J]. 口腔医学, 2025, 45(4): 291-295.

JIA Yinan, XU Xinyuan, XU Xin. Research progress of ionic liquid in the prevention of oral diseases[J]. Stomatology, 2025, 45(4): 291-295.

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