维生素D对种植体骨结合影响的研究进展

doi:10.13591/j.cnki.kqyx.2026.10.015

摘要/Abstract

摘要：

维生素D(vitamin D,VD)作为调控钙磷代谢与免疫稳态的关键激素,在种植体骨结合中发挥重要作用。本文首先综述VD通过维持钙磷平衡、调控RANKL/OPG系统及调节免疫炎症反应促进骨形成的分子机制;进而聚焦全身性补充、种植体表面改性及术中即刻递送等临床干预策略,并分析其在糖尿病等特殊病理状态下的精准应用价值;最后探讨现有争议与潜在应用前景,以期为VD在口腔种植领域的合理评估与转化应用提供理论依据和临床参考。

关键词: 维生素D, 骨结合, 种植体表面改性, 免疫调节

Abstract:

Vitamin D(VD) is a key hormone regulating calcium-phosphorus metabolism and immune homeostasis, and plays an important role in implant osseointegration. This review summarizes the molecular mechanisms by which VD promotes bone formation, including maintenance of calcium-phosphorus homeostasis, regulation of the RANKL/OPG system, and modulation of immune-inflammatory responses. It further focuses on clinical intervention strategies such as systemic supplementation, implant surface modification, and intraoperative delivery, and analyzes their precise application in special pathological conditions such as diabetes mellitus. Finally, the review discusses the potential clinical value and existing controversies regarding VD in implant dentistry, aiming to provide a theoretical basis and clinical reference for rational evaluation and translational application of VD in oral implantology.

Key words: vitamin D, osseointegration, implant surface modification, immune regulation

中图分类号:

R782.13

张乐, 张妍, 汪俊伟, 辛禧瑞. 维生素D对种植体骨结合影响的研究进展[J]. 口腔医学, 2026, 46(10): 811-815.

ZHANG Le, ZHANG Yan, WANG Junwei, XIN Xirui. Research progress on the impact of vitamin D on osseointegration of dental implants[J]. Stomatology, 2026, 46(10): 811-815.

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