口腔-肠道微生物组与辅助生殖的研究进展

doi:10.13591/j.cnki.kqyx.2025.01.001

口腔医学 ›› 2025, Vol. 45 ›› Issue (1): 1-7.doi: 10.13591/j.cnki.kqyx.2025.01.001

• 学部委员专栏 • 下一篇

口腔-肠道微生物组与辅助生殖的研究进展

杨沛岳¹, 彭显², 周学东¹()

1 口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,四川成都(610041)
2 口腔疾病防治全国重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院,四川成都(610041)

收稿日期:2024-09-16 出版日期:2025-01-28 发布日期:2025-01-16
通讯作者: 周学东 E-mail:zhouxd@scu.edu.cn
作者简介:周学东,四川大学二级教授,中国医学科学院学部委员,国家教学名师,华西口腔医院学术院长、口腔疾病防治全国重点实验室主任。主要从事龋病、口腔感染性疾病与全身健康的研究和临床诊疗。以第一完成人获国家科技进步二等奖1项,全国首届创先争优奖,部省级科技进步一等奖6项,国际口腔医学威廉盖茨(Gies)奖2项,爱思唯尔中国高被引学者,主编《牙体牙髓病学》《龋病学》《中华口腔科学》等教材专著19部。研究成果3次入选中国医学科学院颁布的中国医学年度重要进展。
基金资助:
国家自然科学基金(32371523)

Maternal oral-gut microbiome and artificial assisted reproduction

YANG Peiyue¹, PENG Xian², ZHOU Xuedong¹()

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2024-09-16 Online:2025-01-28 Published:2025-01-16

摘要/Abstract

摘要：

口腔和肠道微生物群是人体内最复杂的两大微生物群,在维持人体各种生理平衡中发挥重要作用。辅助生殖技术(assisted reproductive technology, ART)是一种帮助不孕夫妇孕育、生育健康胎儿的治疗技术。目前的辅助生殖技术包括含或不含卵母细胞细胞质内单精子注射的体外受精技术(in vitro fertilization technique of oocyte/intracytoplasmic sperm injection IVF/ICSI)。口腔-肠道微生物的异位定植、代谢产物和免疫调节等多种途径可能影响辅助生殖的效果。本文主要综述了口腔-肠道微生物群对接受人工辅助生殖治疗母体的影响途径、影响机制及具有潜在益处的干预措施。

关键词: 辅助生殖技术, 口腔-肠道微生物, 体外受精, 易位定植

Abstract:

Oral and intestinal microbiota are two of the most complex microbiota in the human body which play important roles in maintaining various physiological balances. Assisted reproductive technology(ART)is an in vitro treatment of gametes and embryos to help women conceive and produce healthy fetuses. Current assisted reproductive technology ART includes in vitro fertilization with or without oocyte intracytoplasmic sperm injection(IVF/ICSI). The ectopic colonization of oral-gut microbiota, their metabolites, and immune regulation mechanisms may affect the outcomes of assisted reproduction. This article mainly reviews the ways, mechanisms and potential beneficial interventions of oral and intestinal microbiota on women receiving artificial assisted reproductive therapy.

Key words: assisted reproductive technology, oral-gut microbes, in vitro fertilization, translocation colonization

中图分类号:

杨沛岳, 彭显, 周学东. 口腔-肠道微生物组与辅助生殖的研究进展[J]. 口腔医学, 2025, 45(1): 1-7.

YANG Peiyue, PENG Xian, ZHOU Xuedong. Maternal oral-gut microbiome and artificial assisted reproduction[J]. Stomatology, 2025, 45(1): 1-7.

图/表 3

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细菌种类早产孕妇羊水	检测部位PCR^[7,30⇓-32]	检测方法F.n
F.n	早产合并早发性新生儿败血症孕妇脐带血及羊水	PCR、16S RNA测序分析^[33]
F.n	先兆早产孕妇胎盘组织	PCR^[34]
F.n	尾静脉注射牙菌斑后小鼠胎盘血管及羊水	PCR、16S RNA测序分析^[6,35-36]
P.g	先兆早产孕妇羊水	PCR^[37]
P.g	早产孕妇的胎盘组织及羊膜上皮	免疫组织化学染色^[38]
P.g	子痫前期孕妇胎盘组织	下一代测序分析^[39]
Bergeyella.sp	早产合并早发性新生儿败血症孕妇脐带血及羊水	16S RNA测序分析^[33]
Bergeyella.sp	早产病例的羊水	16S RNA测序分析^[40]

口腔-肠道微生物组与辅助生殖的研究进展

Maternal oral-gut microbiome and artificial assisted reproduction

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