非编码RNA在调控变异链球菌致龋性中的作用与机制研究进展

doi:10.13591/j.cnki.kqyx.2026.01.012

摘要/Abstract

摘要：

非编码RNA是一类调节性RNA,可以以生理剂量精细调控细菌致病性,有望在减少耐药和细胞毒性的同时有效控制感染。变异链球菌非编码RNA广泛存在于转录组中,通过与RNA、DNA和蛋白质相互作用,调控毒力因子表达、生物膜形成及环境应激响应,并通过多层级网络协同调控龋病的发生与进展。本文就变异链球菌中非编码RNA的生物学功能、作用机制与应用前景作一综述,以期为小分子防龋新材料的研发提供理论基础和探索方向。

关键词: 变异链球菌, 非编码RNA, 致龋性, 调控机制

Abstract:

Noncoding RNAs (ncRNAs), a class of regulatory RNAs, have demonstrated potential to fine-tune bacterial pathogenicity at physiological doses. This offers the dual benefit of reducing antibiotic resistance and minimizing cytotoxic effects, providing a novel strategy for infection control. ncRNAs of Streptococcus mutans (S. mutans) are widely distributed throughout the bacterial transcriptome and regulate the expression of virulence factors, biofilm formation, and stress responses through interactions with RNA, DNA, and proteins. Moreover, they participate in regulatory networks that collectively influence the development and progression of dental caries. This review summarizes the biological functions, regulatory mechanisms, and application prospects of ncRNAs in S. mutans, aiming to provide new insights for the development of small-molecule anti-caries materials.

Key words: Streptococcus mutans, noncoding RNAs, cariogenicity, regulatory mechanisms

中图分类号:

R781.1

周月, 邓雅兰, 胡涛. 非编码RNA在调控变异链球菌致龋性中的作用与机制研究进展[J]. 口腔医学, 2026, 46(1): 70-75.

ZHOU Yue, DENG Yalan, HU Tao. Advances in the regulatory role and mechanisms of noncoding RNAs on cariogenicity of Streptococcus mutans[J]. Stomatology, 2026, 46(1): 70-75.

图/表 1

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