由外泌体介导的牙髓再生相关信号通路研究进展

doi:10.13591/j.cnki.kqyx.2024.10.010

摘要/Abstract

摘要：

外泌体属于细胞外囊泡的一种,通过受体介导的交互作用直接刺激靶细胞,或通过向靶细胞转移各种生物活性分子发挥其生物学功能,在细胞与其微环境之间的细胞间通信中起关键作用。牙髓再生是指从组织工程的角度,将支架、干细胞及信号因子相结合植入到经过适当处理后的牙髓腔里,在支架和信号因子的作用下,干细胞增殖分化形成牙髓牙本质复合物,恢复牙髓的功能。近年来研究发现,p38MAPK信号通路、TGF-β/Smad信号通路、Wnt/β-catenin信号通路以及其他一些相关信号通路是外泌体调控牙髓再生的重要信号通路,在牙髓再生中起着关键的作用。因此,该文基于外泌体调控牙髓再生的相关信号通路的作用机制及研究进展作一综述。

关键词: 外泌体, 牙髓再生, 信号通路, 血管生成

Abstract:

Exosomes are a kind of extracellular vesicles, which directly stimulate target cells through receptor-mediated interaction, or exert their biological functions by transferring various bioactive molecules to target cells, playing a key role in intercellular communication between cells and their microenvironment. From the perspective of tissue engineering, pulp regeneration refers to the combination of scaffolds, stem cells, and signaling factors implanted into a properly treated pulp cavity. Under the action of scaffolds and signaling factors, stem cells proliferate and differentiate to form pulp dentin-like complexes, restoring pulp function. In recent years, studies have found that p38MAPK, TGF-β/SMAD, Wnt/β-Catenin signaling pathway and some other signaling pathways are important for the secretion in regulating pulp regeneration, and play a key role in pulp regeneration. Therefore, this article reviews the mechanism and research progress of signaling pathways related to the regulation of pulp regeneration by exosomes.

Key words: exosomes, pulp regeneration, signaling pathway, angiogenesi

中图分类号:

R781.3

陈子荣, 涂画, 陈乐怡, 徐稳安. 由外泌体介导的牙髓再生相关信号通路研究进展[J]. 口腔医学, 2024, 44(10): 775-779.

CHEN Zirong, TU Hua, CHEN Leyi, XU Wen’an. Advances in signal pathways related to pulp regeneration mediated by exosomes[J]. Stomatology, 2024, 44(10): 775-779.

图/表 1

参考文献 40

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信号通路	发表时间	外泌体来源细胞	靶细胞	效应	文献
p38MAPK	2018年	树突状细胞	HUVECs	促进血管再生,或可用于牙髓再生	[14]
	2016年	DPSCs	DPSCs	促进牙髓样组织再生	[16]
	2022年	DPSCs	HUVECs	促进血管再生,或可用于牙髓再生	[17]
TGF-β/Smad	2021年	SHED	SHED、HUVECs	促进血管再生,或可用于牙髓再生	[19]
	2019年	DPSCs	DPSCs	促进牙源性分化	[21]
Wnt/β-catenin	2020年	SHED	PDLSCs	促进成骨分化,或可用于牙髓牙本质复合体再生	[28]
	2020年	HERS	DPCs	诱导牙髓牙本质样复合体再生	[29]
	2020年	ADSCs	ADSCs	促进成骨分化,或可用于牙髓牙本质复合体再生	[31]