口腔医学 ›› 2025, Vol. 45 ›› Issue (12): 940-946.doi: 10.13591/j.cnki.kqyx.2025.12.011
收稿日期:2024-12-10
出版日期:2025-12-28
发布日期:2025-12-16
通讯作者:
任秀云
E-mail:rxy611@163.com
基金资助:
YUE Yuxu, GAO Jinhua, BAI Xue, REN Xiuyun(
)
Received:2024-12-10
Online:2025-12-28
Published:2025-12-16
Contact:
REN Xiuyun
E-mail:rxy611@163.com
摘要:
牙周炎是一种侵犯牙龈和牙周组织的慢性感染性疾病,牙周炎致病菌可通过血液传播感染多个组织器官,是多种系统性疾病的致病因子。大量研究表明妊娠晚期牙周炎与妊娠不良结局存在高度相关性,感染与炎症是导致妊娠不良结局发生的重要原因。该文就妊娠晚期牙周炎与妊娠不良结局间炎症因子作用及其机制进行综述。
中图分类号:
岳宇旭, 高晋华, 白雪, 任秀云. 妊娠晚期牙周炎与胎儿生长的关系:炎症因子的作用及其机制[J]. 口腔医学, 2025, 45(12): 940-946.
YUE Yuxu, GAO Jinhua, BAI Xue, REN Xiuyun. The role and its mechanism of inflammatory factors in the relationship between periodontitis in the third trimester of pregnancy and fetal growth[J]. Stomatology, 2025, 45(12): 940-946.
| [1] |
Kwon T, Lamster IB, Levin L. Current concepts in the manage-ment of periodontitis[J]. Int Dent J, 2021, 71(6): 462-476.
doi: 10.1111/idj.12630 |
| [2] |
Teles F, Collman RG, Mominkhan D, et al. Viruses, periodontitis, and comorbidities[J]. Periodontol 2000, 2022, 89(1): 190-206.
doi: 10.1111/prd.12435 pmid: 35244970 |
| [3] |
Slots J. Life-threatening pathogens in severe/progressive periodontitis: Focal infection risk, future periodontal practice, role of the Periodontology 2000[J]. Periodontol 2000, 2020, 84(1): 215-216.
doi: 10.1111/prd.12375 pmid: 32844419 |
| [4] |
Sanz M, Marco Del, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report[J]. J Clin Periodontol, 2020, 47(3): 268-288.
doi: 10.1111/jcpe.13189 pmid: 32011025 |
| [5] |
Genco RJ, Sanz M. Clinical and public health implications of periodontal and systemic diseases: An overview[J]. Periodontol 2000, 2020, 83(1): 7-13.
doi: 10.1111/prd.12344 pmid: 32385880 |
| [6] |
Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis[J]. Nat Rev Rheumatol, 2017, 13(10): 606-620.
doi: 10.1038/nrrheum.2017.132 pmid: 28835673 |
| [7] |
Acharya C, Sahingur SE, Bajaj JS. Microbiota, cirrhosis, and the emerging oral-gut-liver axis[J]. JCI Insight, 2017, 2(19): e94416.
doi: 10.1172/jci.insight.94416 |
| [8] |
Schenkein HA, Papapanou PN, Genco R, et al. Mechanisms underlying the association between periodontitis and atherosclerotic disease[J]. Periodontol 2000, 2020, 83(1): 90-106.
doi: 10.1111/prd.12304 pmid: 32385879 |
| [9] |
Hajishengallis G. Periodontitis:From microbial immune subversion to systemic inflammation[J]. Nat Rev Immunol, 2015, 15(1): 30-44.
doi: 10.1038/nri3785 pmid: 25534621 |
| [10] |
Attali E, Yogev Y. The impact of advanced maternal age on pregnancy outcome[J]. Best Pract Res Clin Obstet Gynaecol, 2021, 70: 2-9.
doi: 10.1016/j.bpobgyn.2020.06.006 pmid: 32773291 |
| [11] | Bouariu A, Panaitescu AM, Nicolaides KH. First trimester prediction of adverse pregnancy outcomes-identifying pregnancies at risk from as early as 11-13 weeks[J]. Medicina(Kaunas), 2022, 58(3): 332. |
| [12] |
Fischer RG, Lira R Jr, Retamal-Valdes B, et al. Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis[J]. Braz Oral Res, 2020, 34(suppl 1): e026.
doi: 10.1590/1807-3107bor-2020.vol34.0026 |
| [13] | Dukic J, Ehlert U. Longitudinal course of sex steroids from pregnancy to postpartum[J]. Endocrinology, 2023, 164(8): bqad108. |
| [14] | Hussain T, Murtaza G, Kalhoro DH, et al. Understanding the immune system in fetal protection and maternal infections during pregnancy[J]. J Immunol Res, 2022, 2022: 7567708. |
| [15] |
Massoni RSS, Aranha AMF, Matos FZ, et al. Correlation of periodontal and microbiological evaluations, with serum levels of estradiol and progesterone, during different trimesters of gestation[J]. Sci Rep, 2019, 9(1): 11762.
doi: 10.1038/s41598-019-48288-w pmid: 31409865 |
| [16] |
Liu XM, Si ST, Huang L, et al. Vaginal flora during pregnancy and subsequent risk of preterm birth or prelabor rupture of membranes: A nested case-control study from China[J]. BMC Pregnancy Childbirth, 2023, 23(1): 244.
doi: 10.1186/s12884-023-05564-y |
| [17] |
Figueiredo MGOP, Takita SY, Dourado BMR, et al. Periodontal disease: Repercussions in pregnant woman and newborn health: A cohort study[J]. PLoS One, 2019, 14(11): e0225036.
doi: 10.1371/journal.pone.0225036 |
| [18] |
Micu IC, Roman A, Ticala F, et al. Relationship between preterm birth and post-partum periodontal maternal status: A hospital-based Romanian study[J]. Arch Gynecol Obstet, 2020, 301(5): 1189-1198.
doi: 10.1007/s00404-020-05521-6 pmid: 32274638 |
| [19] |
Pockpa ZAD, Soueidan A, Koffi-Coulibaly NT, et al. Association between periodontitis and preterm birth in a cohort of pregnant women in Ivory coast[J]. Oral Health Prev Dent, 2022, 20: 363-368.
doi: 10.3290/j.ohpd.b3464893 pmid: 36259439 |
| [20] | Opacic J, Maldonado A, Ramseier CA, et al. Influence of periodontitis on pregnancy and childbirth[J]. Swiss Dent J, 2019, 129(7/8): 581-589. |
| [21] |
Saadaoui M, Singh P, Al Khodor S. Oral microbiome and pregnancy: A bidirectional relationship[J]. J Reprod Immunol, 2021, 145: 103293.
doi: 10.1016/j.jri.2021.103293 |
| [22] |
Jang H, Patoine A, Wu TT, et al. Oral microflora and pregnancy: A systematic review and meta-analysis[J]. Sci Rep, 2021, 11(1): 16870.
doi: 10.1038/s41598-021-96495-1 pmid: 34413437 |
| [23] |
Wang WH, Hao JT, An RF. Abnormal vaginal flora correlates with pregnancy outcomes: A retrospective study from 737 pregnant women[J]. Eur J Obstet Gynecol Reprod Biol, 2022, 272: 64-68.
doi: 10.1016/j.ejogrb.2022.03.013 pmid: 35286920 |
| [24] |
Foratori-Junior GA, Mosquim V, Buzalaf MAR, et al. Salivary cytokines levels, maternal periodontitis and infants’ weight at birth: A cohort study in pregnant women with obesity[J]. Placenta, 2021, 115: 151-157.
doi: 10.1016/j.placenta.2021.09.018 pmid: 34628311 |
| [25] | Aliabadi T, Saberi EA, Motameni Tabatabaei A, et al. Antibiotic use in endodontic treatment during pregnancy: A narrative review[J]. Eur J Transl Myol, 2022, 32(4): 10813. |
| [26] | Butera A, Maiorani C, Morandini A, et al. Periodontitis in pregnant women: A possible link to adverse pregnancy outcomes[J]. Healthcare(Basel), 2023, 11(10): 1372. |
| [27] |
Keenan-Devlin LS, Caplan M, Freedman A, et al. Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes[J]. Am J Reprod Immunol, 2021, 86(6): e13497.
doi: 10.1111/aji.v86.6 |
| [28] |
Gomes J, Au F, Basak A, et al. Maternal blood biomarkers and adverse pregnancy outcomes: A systematic review and meta-analysis[J]. Crit Rev Toxicol, 2019, 49(6): 461-478.
doi: 10.1080/10408444.2019.1629873 pmid: 31509042 |
| [29] |
Chehroudi C, Kim H, Wright TE, et al. Dysregulation of inflammatory cytokines and inhibition of VEGFA in the human umbilical cord are associated with negative pregnancy outcomes[J]. Placenta, 2019, 87: 16-22.
doi: S0143-4004(19)30653-8 pmid: 31525711 |
| [30] | Amabebe E, Ogidi H, Anumba DO. Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer[J]. Reprod Fertil, 2022, 3(3): R177-R191. |
| [31] |
Kim C, Cathey AL, Watkins DJ, et al. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico[J]. J Reprod Immunol, 2023, 159: 103991.
doi: 10.1016/j.jri.2023.103991 |
| [32] |
Chaparro A, Realini O, Hernández M, et al. Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and-9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus[J]. J Periodontol, 2021, 92(2): 205-215.
doi: 10.1002/jper.v92.2 |
| [33] |
Gerson KD, Anton L, Ferguson B, et al. Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation[J]. J Reprod Immunol, 2022, 152: 103648.
doi: 10.1016/j.jri.2022.103648 |
| [34] |
Ji Kim H, Choi J, Ji Oh E, et al. Semi-quantitative metalloproteinase-8 rapid test for the prediction of adverse pregnancy outcomes in patients with preterm premature rupture of membranes[J]. Eur J Obstet Gynecol Reprod Biol, 2024, 297: 65-71.
doi: 10.1016/j.ejogrb.2024.03.044 pmid: 38581887 |
| [35] |
Heusler M, Einenkel R, Ehrhardt J, et al. Low abundance Fusobacterium nucleatum supports early pregnancy development: An in vitro study[J]. Front Immunol, 2021, 12: 698045.
doi: 10.3389/fimmu.2021.698045 |
| [36] |
Nissi R, Santala M, Talvensaari-Mattila A. The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: A pilot study[J]. BMC Res Notes, 2021, 14(1): 31.
doi: 10.1186/s13104-021-05442-w pmid: 33482846 |
| [37] |
Ortiz-Sánchez BJ, Juárez-Avelar I, Andrade-Meza A, et al. Periodontitis exacerbation during pregnancy in mice: Role of macrophage migration inhibitory factor as a key inductor[J]. J Periodontal Res, 2024, 59(2): 267-279.
doi: 10.1111/jre.v59.2 |
| [38] | Farias-Jofre M, Romero R, Galaz J, et al. Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes[J]. E Bio Medicine, 2023, 98: 104865. |
| [39] |
Gómez LA, De Avila J, Castillo DM, et al. Porphyromonas gingivalis placental atopobiosis and inflammatory responses in women with adverse pregnancy outcomes[J]. Front Microbiol, 2020, 11: 591626.
doi: 10.3389/fmicb.2020.591626 |
| [40] |
Ahmed M, Casanova NG, Zaghloul N, et al. The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes[J]. Front Physiol, 2023, 14: 1129413.
doi: 10.3389/fphys.2023.1129413 |
| [41] |
Ye Y, Peng L, Chelariu-Raicu A, et al. Prostaglandin E 2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss[J]. Biol Reprod, 2022, 106(5): 910-918.
doi: 10.1093/biolre/ioac030 |
| [42] |
Varga E, Pap R, Jánosa G, et al. IL-6 regulates hepcidin expressionthe BMP/SMAD pathway by altering BMP6, TMPRSS6 and TfR2 expressions at normal and inflammatory conditions in BV2 microglia[J]. Neurochem Res, 2021, 46(5): 1224-1238.
doi: 10.1007/s11064-021-03322-0 pmid: 33835366 |
| [43] |
Sangkhae V, Fisher AL, Chua KJ, et al. Maternal hepcidin determines embryo iron homeostasis in mice[J]. Blood, 2020, 136(19): 2206-2216.
doi: 10.1182/blood.2020005745 pmid: 32584957 |
| [44] |
Hussain T, Murtaza G, Metwally E, et al. The role of oxidative stress and antioxidant balance in pregnancy[J]. Mediators Inflamm, 2021, 2021: 9962860.
doi: 10.1155/mi.v2021.1 |
| [45] |
Farias-Jofre M, Romero R, Galaz J, et al. Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation[J]. Inflamm Res, 2022, 71(5/6): 653-668.
doi: 10.1007/s00011-022-01569-z |
| [46] |
Mahapatra A, Nayak R, Satpathy A, et al. Maternal periodontal status, oral inflammatory load, and systemic inflammation are associated with low infant birth weight[J]. J Periodontol, 2021, 92(8): 1107-1116.
doi: 10.1002/JPER.20-0266 pmid: 33155287 |
| [47] |
Jukic AMZ, Weinberg CR, Mumford SL, et al. Inflammation and conception in a prospective time-to-pregnancy cohort[J]. Epidemiology, 2022, 33(2): 269-277.
doi: 10.1097/EDE.0000000000001451 pmid: 35104260 |
| [48] | 白雪, 高晋华, 任秀云. 牙周炎与不良妊娠结局相关关系的研究进展[J]. 口腔医学, 2022, 42(10):932-937. |
| [1] | 姜玉涵, 尤品哲, 赵雪芸, 林默涵, 施博伟, 蒲俊霖, 贾波. 佛手柑内酯抗炎抑制骨吸收治疗牙周炎的研究[J]. 口腔医学, 2025, 45(9): 667-674. |
| [2] | 李昊谕, 吴懿宽, 丁佩惠, 李晓军. 牙周致病菌与消化系统肿瘤相关性的研究进展[J]. 口腔医学, 2025, 45(9): 691-695. |
| [3] | 郝艳迪, 刘晔, 高鹏玉, 杨景舒, 徐全臣. 巨噬细胞与牙周炎关系的研究进展[J]. 口腔医学, 2025, 45(9): 696-700. |
| [4] | 贺梦柯, 鲁嘉韦, 段晖, 罗礼君. 人工智能技术在牙周炎影像诊断中的研究进展[J]. 口腔医学, 2025, 45(6): 460-464. |
| [5] | 高晶萍, 贾凌璐, 梁洪宁, 文勇. 熊果苷通过NF-κB信号通路减轻脂多糖对人牙周膜干细胞成骨分化的抑制作用[J]. 口腔医学, 2025, 45(5): 347-354. |
| [6] | 徐晟瀛, 孙徐麟, 黄佳萍, 石卓瑾, 丁佩惠. 龈下喷砂治疗牙周炎与种植体周围炎的研究进展[J]. 口腔医学, 2025, 45(5): 380-385. |
| [7] | 范雅丹, 宋忠臣, 廖悦, 程岚, 葛琳华. 未控制的2型糖尿病伴Ⅲ/Ⅳ期牙周炎患者龈下菌斑菌群结构及代谢功能分析[J]. 口腔医学, 2025, 45(12): 887-894. |
| [8] | 赛云涛, 王智, 耿淳, 赵宁, 朱超. 铒钕双波长激光辅助吸烟牙周炎患者非手术治疗的临床效果评价[J]. 口腔医学, 2025, 45(12): 914-918. |
| [9] | 程昶, 陈武. 铒激光辅助治疗种植体周炎的疗效及机制初探[J]. 口腔医学, 2025, 45(12): 927-931. |
| [10] | 谢晓昱, 李毅. 镧系稀土元素在牙周病学领域的应用与研究进展[J]. 口腔医学, 2025, 45(12): 946-950. |
| [11] | 许悦, 夏娇娇, 陈玉莲, 陈强. 光动力疗法联合甘氨酸龈下喷砂对治疗Ⅲ期牙周炎残留牙周袋的临床疗效研究[J]. 口腔医学, 2025, 45(10): 760-764. |
| [12] | 陈旭, 李璐, 王晓茜, 王天尧, 徐艳. Ⅲ/Ⅳ期牙周炎的临床诊治决策进展[J]. 口腔医学, 2025, 45(1): 13-17. |
| [13] | 彭焱, 张驰, 高雳, 李希庭, 赵川江. Ⅳ期牙周炎患者的正畸考量和时机选择[J]. 口腔医学, 2025, 45(1): 25-36. |
| [14] | 包佳琦, 王中秀, 冯贻苗, 雷利红, 陈莉丽. 正畸治疗中牙周硬组织相关并发症的处理[J]. 口腔医学, 2025, 45(1): 37-44. |
| [15] | 杨泽, 潘亚萍. 牙周炎患者的种植考量因素[J]. 口腔医学, 2025, 45(1): 8-12. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||
苏公网安备32010602011670号