口腔医学 ›› 2025, Vol. 45 ›› Issue (12): 946-950.doi: 10.13591/j.cnki.kqyx.2025.12.012

• 综述 • 上一篇    下一篇

镧系稀土元素在牙周病学领域的应用与研究进展

谢晓昱1,2, 李毅1()   

  1. 1 吉林大学口腔医院儿童口腔科,吉林长春(130021)
    2 吉林省牙发育及颌骨重塑与再生重点实验室,吉林长春(130021)
  • 收稿日期:2024-10-28 出版日期:2025-12-28 发布日期:2025-12-16
  • 通讯作者: 李毅 E-mail:lyi99@jlu.edu.cn
  • 基金资助:
    吉林省财政厅科技项目(jcsz2023481-1);吉林省科技厅项目(20240304039SF)

Application and research progress of lanthanide elements in the field of periodontal diseases

XIE Xiaoyu1,2, LI Yi1()   

  1. Department of Pediatric Dentistry, School of Stomatology, Jilin University, Changchun 130021, China
  • Received:2024-10-28 Online:2025-12-28 Published:2025-12-16
  • Contact: LI Yi E-mail:lyi99@jlu.edu.cn

摘要:

稀土元素,也被称为稀土金属,是地壳内的一系列金属元素的统称,涵盖了15种镧系元素以及钪、钇。稀土元素因其化合价高、化学性质活泼,以及独特的光学、电学、磁性等性能,目前已经在医疗、化工、超导等多个行业中得到广泛应用。牙周炎是一种炎症性、破坏性疾病,通过引发炎症反应从而破坏骨平衡,最终导致牙齿脱落。该文首先介绍了镧系元素抗菌、骨修复、抗氧化应激以及抗炎作用,最后讨论了稀土元素能否用于口腔牙周病和种植体周围炎的治疗,最终目的在于为镧系元素在临床上的应用提供理论支持。

关键词: 镧系元素, 牙周炎, 抗菌, 抗炎, 骨修复, 氧化应激

Abstract:

Rare earth elements, also known as rare earth metals, are a collective term for a series of metal elements in the Earth’s crust, covering 15 lanthanide elements as well as scandium and yttrium. Due to their high electrovalence, active chemical properties, and unique optical, electrical, and magnetic properties, rare earth elements have been widely used in multiple fields such as medical treatment, chemical engineering, and superconductivity. Periodontitis is an inflammatory and destructive disease that disrupts bone balance by triggering an inflammatory response,eventually leading to tooth loss. This article first introduces the antibacterial effect, bone repair effect, antioxidant stress effect, and anti-inflammatory effect of lanthanide elements, and then discusses whether rare earth elements can be used for the treatment of oral periodontitis and peri-implantitis, with the ultimate goal of providing theoretical support for the clinical application of lanthanide elements.

Key words: lanthanide elements, periodontitis, antibacterial, anti-inflammation, bone repair, reactive oxygen species

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