神经调节素-1在神经损伤修复中的作用机制及研究现状

doi:10.13591/j.cnki.kqyx.2022.06.016

Abstract

Abstract: Nerve Injury is a common and multiple disease in clinical practice, and can be divided into peripheral nervous injury (PNI) and central nervous injury (CNI). At present, main treatment methods are autologous nerve transplantation, allogeneic nerve transplantation, cell promoting therapy and tissue engineering. Compared with the other three methods, the development of tissue engineering method will fundamentally solve problems of dysfunction or loss of treatment caused by tissue and organ defects to achieve perfect morphological repair. Neuregulin-1 (NRG-1), as a classical growth and differentiation factor, can inhibit cell senescence, promote cell proliferation and differentiation, and promote nerve repair after PNI and CNI through related signaling pathways when applied to tissue engineering. This review focuses on the structure and function of NRG-1 and its role and mechanism in PNI and CNI repair.

Key words: neuregulin-1, peripheral nervous injury, central nervous injury, signaling pathway, Wallerian degeneration, axon regeneration, tissue engineering

CLC Number:

YAO Lihong, XU Wanqiu, XU Xiaohang, XUE Bing, XI Hualei, WANG Xiumei. The mechanism and research status of NRG-1 in nerve injury repair[J]. Stomatology, 2022, 42(6): 567-570.

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The mechanism and research status of NRG-1 in nerve injury repair

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