组蛋白修饰在口腔鳞状细胞癌中的研究进展

doi:10.13591/j.cnki.kqyx.2022.07.015

Abstract

Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial region, but when OSCC patients seek medical advice, the disease has often reached an advanced stage and tumor metastasis has appeared, resulting in a poor prognosis. Its pathogenesis is still unclear, and there is still demand for effective diagnostic and therapeutic targets to monitor the invasion, metastasis and recurrence of OSCC. Studies show that histone modification changes chromatin structure, thereby affecting transcriptional activity of related downstream genes and regulating gene expression levels, which plays an important role in biological detection, pathological grading and staging, prognosis of OSCC. This article reviews current research progress of histone modification including methylation, acetylation, phosphorylation, ubiquitination and ADP-ribosylation in oral squamous cell carcinoma.

Key words: oral squamous cell carcinoma, histone modification, biomarker, molecular targeted therapy

CLC Number:

R739.85

HOU Yiming, LI Na, YU Wenqian, CHEN Lei. Research progress of histone modification in oral squamous cell carcinoma[J]. Stomatology, 2022, 42(7): 650-654.

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Research progress of histone modification in oral squamous cell carcinoma

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