吸烟饮酒对不同年龄OSCC患者预后的影响

doi:10.13591/j.cnki.kqyx.2022.06.007

Abstract

Abstract: Objective To explore the prognostic factors of oral squamous cell carcinoma patients(OSCC) by analyzing the clinical data, so as to focus on the influence of smoking and drinking history on the prognosis of OSCC patients in different age groups. Methods The data of 215 patients who were diagnosed with OSCC and admitted into the Department of Maxillofacial Surgery of Stomatological Hospital Affiliated to Xi′an Jiaotong University from June 2010 to June 2021 were collected and analyzed retrospectively. Patients aged ≤45 years old were defined as the young group, and patients aged > 45 years old were defined as the middle-aged and elderly group. Meanwhile, patients were divided into two groups according to whether they had a history of smoking and drinking exposure.The prognosis was mainly evaluated by disease free surivival, distant metastasis-free survival rate and overall survival rate. Results Among all the cases included, the incidence of tongue and other locations malignant tumor in the young group was significantly higher than that in the middle-aged and elderly group (P<0.05). By analyzing prognostic indicators of all patients, it was found that the clinical stage and differentiation degree were significantly correlated with prognostic indicators(P<0.05); among the young patients, it was found that smoking and drinking and clinical stage were significantly correlated with prognosis(P<0.05). Univariate prognostic analysis showed that clinical stage was correlated with prognosis in middle-aged and elderly patients(P<0.05), but there was no significant difference in multivariate analysis(P>0.05). Through survival rate analysis, it was found that smoking and drinking were the risk factors of poor prognosis in young patients, but there was no significant difference in middle-aged and elderly patients. Conclusion Smoking and drinking history has a great influence on prognosis in young patients. In clinical practice, attention should be paid to young patients with smoking and drinking history.

Key words: oral squamous cell carcinoma, smoking, alcohol drinking, survival, age

CLC Number:

R739.8

GUO Zhichen, JING Sili, HU Xiaoyi, ZHANG Zhou, CUI Hao, NA Sijia. Effect of smoking and drinking exposure history on prognosis of patients with oral squamous cell carcinoma at different ages[J]. Stomatology, 2022, 42(6): 521-524.

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Effect of smoking and drinking exposure history on prognosis of patients with oral squamous cell carcinoma at different ages

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