PI3K/AKT信号通路在2型糖尿病患者种植体骨结合中作用机制的研究进展

doi:10.13591/j.cnki.kqyx.2022.11.013

Abstract

Abstract: Oral implantation is currently considered as the preferred treatment for patients with tooth loss, but diabetes is still a relative contraindication for implant therapy. The hyperglycemic environment and microvascular lesions of diabetic patients may affect osteoblasts, their functions and bone metabolism, leading to implant failure. At present, the mechanism of diabetes affecting binding between implant and bone has not been clarified. PI3K/AKT signaling pathway plays an important role in bone tissue metabolism and can promote the proliferation and differentiation of osteoblasts. In addition, PI3K/AKT/mTOR is also a classic pathway responding to insulin signaling. This paper reviews progress of research on the mechanism of PI3K/AKT signaling pathway in type 2 diabetes and implant osseointegration, respectively, which may lay a good foundation for future research on promoting peri-implant bone regeneration in diabetic patients.

Key words: PI3K/AKT, type 2 diabetes mellitus, implant osseointegration, insulin resistance, osteogenic differentiation

CLC Number:

R780.2

DONG Shuo, TANG Chunbo. Progress of research on the mechanism of PI3K/AKT signaling pathway in implant osseointegration in patients with type 2 diabetes mellitus[J]. Stomatology, 2022, 42(11): 1026-1030.

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Progress of research on the mechanism of PI3K/AKT signaling pathway in implant osseointegration in patients with type 2 diabetes mellitus

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