UHRF1在口腔黏膜鳞癌中的表达及其对临床预后的价值研究

doi:10.13591/j.cnki.kqyx.2022.12.007

Abstract

Abstract: Objective To analyze the expression and clinical significance of ubiquitin like with PHD and ring finger domain 1(UHRF1)in oral squamous cell carcinoma. Methods Patients with primary oral squamous cell carcinoma who underwent surgery at the department of oral and maxillofacial surgery, The First Affiliated Hospital of USTC from 2008 to 2016 were collected. The expression of UHRF1 in tumor tissues, adjacent normal tissues and invasion front were evaluated by immunofluorescence staining to explore the difference in UHRF1 expression. The patients were divided into high expression group and low expression group according to the value of immunoreactivity intensity distribution index(IRIDI). Relationship between the expression level of UHRF1 and clinicopathological characteristics of patients was analyzed. The correlation between the relative expression of UHRF1 in oral squamous cell carcinoma and survival rate was analyzed by Kaplan Meier method, and the relevant risk factors affecting the survival rate of patients with oral squamous cell carcinoma were analyzed by Cox risk regression model. Results Compared with the tumor invasion front and adjacent normal tissues, UHRF1 was highly expressed in oral squamous cell carcinoma(P<0.01). The expression level of UHRF1 in oral squamous cell carcinoma was correlated with gender, tumor size and depth of invasion(P<0.05). There were significant differences in tumor recurrence, cervical lymph node metastasis, occult lymph node metastasis and survival rate between low expression group and high expression group(P<0.05). Cox risk regression model showed that the expression level of UHRF1 was a risk factor for the prognosis of patients with oral squamous cell carcinoma(P=0.002). Conclusion UHRF1 is highly expressed in oral squamous cell carcinoma, and its expression level is closely related to the clinical prognosis of patients with oral squamous cell carcinoma. It can be used as a valuable prognostic index of oral squamous cell carcinoma.

Key words: UHRF1, oral cancer, squamous cell carcinoma, prognosis

CLC Number:

R739.85

DUAN Xianjie, WENG Haiyan, SHEN Guodong, SI Chengyun, AN Xingfei, ZHANG Liyu, ZHOU Yu. Expression of UHRF1 in oral squamous cell carcinoma and its value in clinical prognosis[J]. Stomatology, 2022, 42(12): 1091-1096.

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Expression of UHRF1 in oral squamous cell carcinoma and its value in clinical prognosis

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