妊娠晚期牙周炎与胎儿生长的关系:炎症因子的作用及其机制

doi:10.13591/j.cnki.kqyx.2025.12.011

Abstract

Abstract:

Periodontitis is a chronic destructive disease that invades the gums and periodontal tissues, and the pathogenic bacteria of periodontitis can infect multiple tissues and organs through blood, and are the causative agents of a variety of systemic diseases. A large number of studies have shown that periodontitis during the third trimester of pregnancy is highly correlated with adverse pregnancy outcomes, with infection and inflammation as important causes. This article reviews the role and mechanism of inflammatory factors in periodontitis in the third trimester of pregnancy and adverse outcomes of pregnancy.

Key words: periodontitis, adverse pregnancy outcomes, inflammatory factors

CLC Number:

R781.42

YUE Yuxu, GAO Jinhua, BAI Xue, REN Xiuyun. The role and its mechanism of inflammatory factors in the relationship between periodontitis in the third trimester of pregnancy and fetal growth[J]. Stomatology, 2025, 45(12): 940-946.

References 48

[1]	Kwon T, Lamster IB, Levin L. Current concepts in the manage-ment of periodontitis[J]. Int Dent J, 2021, 71(6): 462-476. doi: 10.1111/idj.12630
[2]	Teles F, Collman RG, Mominkhan D, et al. Viruses, periodontitis, and comorbidities[J]. Periodontol 2000, 2022, 89(1): 190-206. doi: 10.1111/prd.12435 pmid: 35244970
[3]	Slots J. Life-threatening pathogens in severe/progressive periodontitis: Focal infection risk, future periodontal practice, role of the Periodontology 2000[J]. Periodontol 2000, 2020, 84(1): 215-216. doi: 10.1111/prd.12375 pmid: 32844419
[4]	Sanz M, Marco Del, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report[J]. J Clin Periodontol, 2020, 47(3): 268-288. doi: 10.1111/jcpe.13189 pmid: 32011025
[5]	Genco RJ, Sanz M. Clinical and public health implications of periodontal and systemic diseases: An overview[J]. Periodontol 2000, 2020, 83(1): 7-13. doi: 10.1111/prd.12344 pmid: 32385880
[6]	Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis[J]. Nat Rev Rheumatol, 2017, 13(10): 606-620. doi: 10.1038/nrrheum.2017.132 pmid: 28835673
[7]	Acharya C, Sahingur SE, Bajaj JS. Microbiota, cirrhosis, and the emerging oral-gut-liver axis[J]. JCI Insight, 2017, 2(19): e94416. doi: 10.1172/jci.insight.94416
[8]	Schenkein HA, Papapanou PN, Genco R, et al. Mechanisms underlying the association between periodontitis and atherosclerotic disease[J]. Periodontol 2000, 2020, 83(1): 90-106. doi: 10.1111/prd.12304 pmid: 32385879
[9]	Hajishengallis G. Periodontitis:From microbial immune subversion to systemic inflammation[J]. Nat Rev Immunol, 2015, 15(1): 30-44. doi: 10.1038/nri3785 pmid: 25534621
[10]	Attali E, Yogev Y. The impact of advanced maternal age on pregnancy outcome[J]. Best Pract Res Clin Obstet Gynaecol, 2021, 70: 2-9. doi: 10.1016/j.bpobgyn.2020.06.006 pmid: 32773291
[11]	Bouariu A, Panaitescu AM, Nicolaides KH. First trimester prediction of adverse pregnancy outcomes-identifying pregnancies at risk from as early as 11-13 weeks[J]. Medicina(Kaunas), 2022, 58(3): 332.
[12]	Fischer RG, Lira R Jr, Retamal-Valdes B, et al. Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis[J]. Braz Oral Res, 2020, 34(suppl 1): e026. doi: 10.1590/1807-3107bor-2020.vol34.0026
[13]	Dukic J, Ehlert U. Longitudinal course of sex steroids from pregnancy to postpartum[J]. Endocrinology, 2023, 164(8): bqad108.
[14]	Hussain T, Murtaza G, Kalhoro DH, et al. Understanding the immune system in fetal protection and maternal infections during pregnancy[J]. J Immunol Res, 2022, 2022: 7567708.
[15]	Massoni RSS, Aranha AMF, Matos FZ, et al. Correlation of periodontal and microbiological evaluations, with serum levels of estradiol and progesterone, during different trimesters of gestation[J]. Sci Rep, 2019, 9(1): 11762. doi: 10.1038/s41598-019-48288-w pmid: 31409865
[16]	Liu XM, Si ST, Huang L, et al. Vaginal flora during pregnancy and subsequent risk of preterm birth or prelabor rupture of membranes: A nested case-control study from China[J]. BMC Pregnancy Childbirth, 2023, 23(1): 244. doi: 10.1186/s12884-023-05564-y
[17]	Figueiredo MGOP, Takita SY, Dourado BMR, et al. Periodontal disease: Repercussions in pregnant woman and newborn health: A cohort study[J]. PLoS One, 2019, 14(11): e0225036. doi: 10.1371/journal.pone.0225036
[18]	Micu IC, Roman A, Ticala F, et al. Relationship between preterm birth and post-partum periodontal maternal status: A hospital-based Romanian study[J]. Arch Gynecol Obstet, 2020, 301(5): 1189-1198. doi: 10.1007/s00404-020-05521-6 pmid: 32274638
[19]	Pockpa ZAD, Soueidan A, Koffi-Coulibaly NT, et al. Association between periodontitis and preterm birth in a cohort of pregnant women in Ivory coast[J]. Oral Health Prev Dent, 2022, 20: 363-368. doi: 10.3290/j.ohpd.b3464893 pmid: 36259439
[20]	Opacic J, Maldonado A, Ramseier CA, et al. Influence of periodontitis on pregnancy and childbirth[J]. Swiss Dent J, 2019, 129(7/8): 581-589.
[21]	Saadaoui M, Singh P, Al Khodor S. Oral microbiome and pregnancy: A bidirectional relationship[J]. J Reprod Immunol, 2021, 145: 103293. doi: 10.1016/j.jri.2021.103293
[22]	Jang H, Patoine A, Wu TT, et al. Oral microflora and pregnancy: A systematic review and meta-analysis[J]. Sci Rep, 2021, 11(1): 16870. doi: 10.1038/s41598-021-96495-1 pmid: 34413437
[23]	Wang WH, Hao JT, An RF. Abnormal vaginal flora correlates with pregnancy outcomes: A retrospective study from 737 pregnant women[J]. Eur J Obstet Gynecol Reprod Biol, 2022, 272: 64-68. doi: 10.1016/j.ejogrb.2022.03.013 pmid: 35286920
[24]	Foratori-Junior GA, Mosquim V, Buzalaf MAR, et al. Salivary cytokines levels, maternal periodontitis and infants’ weight at birth: A cohort study in pregnant women with obesity[J]. Placenta, 2021, 115: 151-157. doi: 10.1016/j.placenta.2021.09.018 pmid: 34628311
[25]	Aliabadi T, Saberi EA, Motameni Tabatabaei A, et al. Antibiotic use in endodontic treatment during pregnancy: A narrative review[J]. Eur J Transl Myol, 2022, 32(4): 10813.
[26]	Butera A, Maiorani C, Morandini A, et al. Periodontitis in pregnant women: A possible link to adverse pregnancy outcomes[J]. Healthcare(Basel), 2023, 11(10): 1372.
[27]	Keenan-Devlin LS, Caplan M, Freedman A, et al. Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes[J]. Am J Reprod Immunol, 2021, 86(6): e13497. doi: 10.1111/aji.v86.6
[28]	Gomes J, Au F, Basak A, et al. Maternal blood biomarkers and adverse pregnancy outcomes: A systematic review and meta-analysis[J]. Crit Rev Toxicol, 2019, 49(6): 461-478. doi: 10.1080/10408444.2019.1629873 pmid: 31509042
[29]	Chehroudi C, Kim H, Wright TE, et al. Dysregulation of inflammatory cytokines and inhibition of VEGFA in the human umbilical cord are associated with negative pregnancy outcomes[J]. Placenta, 2019, 87: 16-22. doi: S0143-4004(19)30653-8 pmid: 31525711
[30]	Amabebe E, Ogidi H, Anumba DO. Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer[J]. Reprod Fertil, 2022, 3(3): R177-R191.
[31]	Kim C, Cathey AL, Watkins DJ, et al. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico[J]. J Reprod Immunol, 2023, 159: 103991. doi: 10.1016/j.jri.2023.103991
[32]	Chaparro A, Realini O, Hernández M, et al. Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and-9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus[J]. J Periodontol, 2021, 92(2): 205-215. doi: 10.1002/jper.v92.2
[33]	Gerson KD, Anton L, Ferguson B, et al. Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation[J]. J Reprod Immunol, 2022, 152: 103648. doi: 10.1016/j.jri.2022.103648
[34]	Ji Kim H, Choi J, Ji Oh E, et al. Semi-quantitative metalloproteinase-8 rapid test for the prediction of adverse pregnancy outcomes in patients with preterm premature rupture of membranes[J]. Eur J Obstet Gynecol Reprod Biol, 2024, 297: 65-71. doi: 10.1016/j.ejogrb.2024.03.044 pmid: 38581887
[35]	Heusler M, Einenkel R, Ehrhardt J, et al. Low abundance Fusobacterium nucleatum supports early pregnancy development: An in vitro study[J]. Front Immunol, 2021, 12: 698045. doi: 10.3389/fimmu.2021.698045
[36]	Nissi R, Santala M, Talvensaari-Mattila A. The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: A pilot study[J]. BMC Res Notes, 2021, 14(1): 31. doi: 10.1186/s13104-021-05442-w pmid: 33482846
[37]	Ortiz-Sánchez BJ, Juárez-Avelar I, Andrade-Meza A, et al. Periodontitis exacerbation during pregnancy in mice: Role of macrophage migration inhibitory factor as a key inductor[J]. J Periodontal Res, 2024, 59(2): 267-279. doi: 10.1111/jre.v59.2
[38]	Farias-Jofre M, Romero R, Galaz J, et al. Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes[J]. E Bio Medicine, 2023, 98: 104865.
[39]	Gómez LA, De Avila J, Castillo DM, et al. Porphyromonas gingivalis placental atopobiosis and inflammatory responses in women with adverse pregnancy outcomes[J]. Front Microbiol, 2020, 11: 591626. doi: 10.3389/fmicb.2020.591626
[40]	Ahmed M, Casanova NG, Zaghloul N, et al. The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes[J]. Front Physiol, 2023, 14: 1129413. doi: 10.3389/fphys.2023.1129413
[41]	Ye Y, Peng L, Chelariu-Raicu A, et al. Prostaglandin E 2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss[J]. Biol Reprod, 2022, 106(5): 910-918. doi: 10.1093/biolre/ioac030
[42]	Varga E, Pap R, Jánosa G, et al. IL-6 regulates hepcidin expressionthe BMP/SMAD pathway by altering BMP6, TMPRSS6 and TfR2 expressions at normal and inflammatory conditions in BV2 microglia[J]. Neurochem Res, 2021, 46(5): 1224-1238. doi: 10.1007/s11064-021-03322-0 pmid: 33835366
[43]	Sangkhae V, Fisher AL, Chua KJ, et al. Maternal hepcidin determines embryo iron homeostasis in mice[J]. Blood, 2020, 136(19): 2206-2216. doi: 10.1182/blood.2020005745 pmid: 32584957
[44]	Hussain T, Murtaza G, Metwally E, et al. The role of oxidative stress and antioxidant balance in pregnancy[J]. Mediators Inflamm, 2021, 2021: 9962860. doi: 10.1155/mi.v2021.1
[45]	Farias-Jofre M, Romero R, Galaz J, et al. Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation[J]. Inflamm Res, 2022, 71(5/6): 653-668. doi: 10.1007/s00011-022-01569-z
[46]	Mahapatra A, Nayak R, Satpathy A, et al. Maternal periodontal status, oral inflammatory load, and systemic inflammation are associated with low infant birth weight[J]. J Periodontol, 2021, 92(8): 1107-1116. doi: 10.1002/JPER.20-0266 pmid: 33155287
[47]	Jukic AMZ, Weinberg CR, Mumford SL, et al. Inflammation and conception in a prospective time-to-pregnancy cohort[J]. Epidemiology, 2022, 33(2): 269-277. doi: 10.1097/EDE.0000000000001451 pmid: 35104260
[48]	白雪, 高晋华, 任秀云. 牙周炎与不良妊娠结局相关关系的研究进展[J]. 口腔医学, 2022, 42(10):932-937.

The role and its mechanism of inflammatory factors in the relationship between periodontitis in the third trimester of pregnancy and fetal growth

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