PKM2在牙周炎症中的作用机制研究进展

doi:10.13591/j.cnki.kqyx.2026.02.011

Abstract

Abstract:

Enhanced glycolysis and other host metabolic reprogramming are recognized as core drivers of sustained inflammation. As a rate-limiting enzyme of glycolysis, the pyruvate kinase M2 (PKM2) exerts important effects on various chronic inflammatory diseases such as periodontitis. This review focuses on the mu.PNGaceted regulatory mechanisms of PKM2 in periodontal inflammatory responses and further explores the potential of PKM2-targeted therapies, aiming to provide novel insights into the pathogenesis and clinical management of periodontitis.

Key words: periodontitis, pyruvate kinase M2 (PKM2), glycolysis, metabolic reprogramming

CLC Number:

R781.4

GAO Han, ZHOU Yue. Research progress of PKM2-mediated regulatory pathways in periodontitis[J]. Stomatology, 2026, 46(2): 148-151.

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Research progress of PKM2-mediated regulatory pathways in periodontitis

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