Abstract:

This paper focuses on the transformation of pulp regeneration technology from being limited to young permanent teeth to being extended to mature permanent teeth, and elaborates on the research progress and challenges of pulp regeneration in mature permanent teeth. In terms of research progress, through the analysis of clinical randomized controlled trials, systematic reviews and Meta-analyses, etc., it has been confirmed that the pulp regeneration technology for mature permanent teeth is feasible and has a high success rate. However, pulp regeneration in mature permanent teeth faces numerous challenges, such as infection control, sources of stem cells and scaffolds, sources of growth factors, and the aging microenvironment. Pulp regeneration holds great potential and challenges in the treatment of mature permanent teeth. Although the prospects are promising, a series of problems need to be overcome, and a sound and standardized treatment system needs to be established before pulp regeneration can be promoted as an effective treatment for diseases such as pulp necrosis of mature permanent teeth.

Key words: regenerative endodontics, permanent teeth, dental pulp stem cells, revascularization