Abstract:

Objective To compare the effectiveness, and safety of remazolam and propofol for supernumerary tooth extraction in oral day surgery on children. Methods Eighty patients who underwent tooth extraction in the Outpatient Department of Jiangsu Stomatological Hospital from October 2022 to April 2023 were selected and divided into propofol group (P group) and remazolam group (R group) by random number table, with 40 cases in each group. P group was given 2 mg/kg for anesthesia induction, maintained propofol 6-12 mg/(kg·h),remifentanil 10 μg/(kg·h). R group was given 0.3 mg/kg for anesthesia induction, maintained remazolam 0.8-1.5 mg/(kg·h),remifentanil 10 μg/(kg·h). HR and MAP were recorded before induction of anesthesia (T0), before endotracheal intubation (T1), after endotracheal intubation (T2), at the beginning of surgery (T3), at the end of surgery (T4), after extubation (T5), 5 minutes after extubation (T6). The operation time, the time of consciousness disappearance, extubation time and sedation failure rate were recorded. Results Compared with group P, the MAP and HR of patients in group R increased significantly at T1 to T4 (P<0.05); the time of consciousness disappearance was longer (P<0.05); the extubation time were shorter (P<0.05). The sedation success rate in both group was 100%. Compared with group P, remedial sedation rate in remazolam group was higher (P<0.05). Total incidence of major adverse events in group R (2.50%) was lower than that in group P (47.5%)(P<0.05). There was no significant difference in MAP and HR at T0, T5 and T6 between the two groups (P>0.05). There were no significant difference in PAED scores after awakening (P>0.05). Conclusion Remazolam has better anesthetic effect than propofol on supernumerary tooth extraction in oral day surgery on children, which has good clinical application value.

Key words: remazolam, propofol, supernumerary teeth, oral day surgery