Stomatology ›› 2026, Vol. 46 ›› Issue (4): 266-271.doi: 10.13591/j.cnki.kqyx.2026.04.005

• Basic and Clinical Research • Previous Articles     Next Articles

Risk factors for cortical bone defect of the mandibular canal related to mandibular third molars with high-risk of inferior alveolar nerve injury

YANG Haochuan1,2,3, YANG Shengjun4, LIU Jingyi1,2,3, XU Binhao1,2,3, WANG Dongmiao1,2,3()   

  1. Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2025-10-09 Online:2026-04-28 Published:2026-04-17
  • Contact: WANG Dongmiao E-mail:wdm9921@njmu.edu.cn

Abstract:

Objective To identify risk factors influencing cortical bone defect of the mandibular canal related to mandibular third molar with high-risk of inferior alveolar nerve injury (IAN-risk M3). Methods A retrospective study was conducted on 2 516 patients (3 389 M3s) with IAN-risk M3s who attended the Affiliated Stomatological Hospital of Nanjing Medical University between January 2018 and December 2021. All patients underwent panoramic radiography and cone-beam computed tomography (CBCT). Mandibular canal cortical bone condition was assessed on CBCT, and multivariate Logistic regression analysis was performed to determine significant risk factors for cortical bone defect. Results The incidence of mandibular canal cortical bone defect associated with IAN-risk M3 was 38.15%. Mesioangular, middle and low levels impactions, Class Ⅱ and Class Ⅲ impactions, mandibular canal positioned lingual to or between the M3 roots, and a narrow canal morphology were significant risk factors for cortical bone defect. Conclusion Mandibular canal cortical bone defect associated with IAN-risk M3s have a relatively high prevalence and were significantly correlated with radiographic characteristics. Preoperative CBCT evaluation in such cases can assist clinicians in optimizing surgical strategies for third molar extraction and reducing the risk of inferior alveolar nerve injury.

Key words: mandibular third molar, mandibular canal cortical bone defect, CBCT, risk factors

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