Stomatology ›› 2022, Vol. 42 ›› Issue (2): 184-187.doi: 10.13591/j.cnki.kqyx.2022.02.018

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Advances of research on melatonin in oral implantation therapy

ZHANG Cheng, LU Di, LIU Zongxiang, WANG Penglai   

  1. School of Stomatology, Xuzhou Medical University, Xuzhou 221004, China
  • Revised:2021-09-26 Online:2022-02-28 Published:2022-02-25

Abstract: Melatonin is a tryptophan-derived hormone synthesized by brain's pineal gland at night, which involves in controlling circadian rhythm, body temperature, sexual development and reproductive cycle. In recent years, a large number of studies have found that melatonin can accelerate osseointegration of implants and reduce inflammatory response and oxidative stress injury of peri-implantitis, which has a wide application prospect in the field of oral implantation. In this review, the specific mechanism of melatonin in bone metabolism and inflammation regulation and advances of research on melatonin as an exogenous chemical factor in oral implantation were reviewed, aiming to provide new ideas for obtaining early osseointegration of implants, preventing and treating peri-implantitis.

Key words: melatonin, peri-implantitis, osseointegration, oxidative stress

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