NF-κB信号通路在口腔鳞状细胞癌中作用的研究进展

doi:10.13591/j.cnki.kqyx.2025.12.013

Abstract

Abstract:

Oral cancer is one of the most prevalent malignancies, with approximately 90% of cases being oral squamous cell carcinoma(OSCC), which exhibits rapid growth, strong infiltrative ability, high recurrence rates, and a propensity for metastasis, posing a severe threat to human health. Emerging evidence indicates that aberrant activation of the NF-κB signaling pathway is closely associated with the pathogenesis and progression of OSCC. This article delves into the multifaceted regulatory roles of the NF-κB signaling pathway in OSCC, encompassing its influence on inflammatory responses, cell proliferation, apoptosis, invasion, metastasis, and drug resistance. Furthermore, it analyzes the therapeutic strategies and drug development prospects for OSCC treatment with the NF-κB signaling pathway as a potential therapeutic target.

Key words: oral squamous cell carcinoma, NF-κB signaling pathway, malignant neoplasms

CLC Number:

R739.85

CHEN Ruiye, LIU Yiqing, ZHANG Lu, CHEN Yuzhao, QIU Feng. Research progress of the role of NF-κB signaling pathway in oral squamous cell carcinoma[J]. Stomatology, 2025, 45(12): 951-955.

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Research progress of the role of NF-κB signaling pathway in oral squamous cell carcinoma

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