具核梭杆菌与口腔鳞状细胞癌关系的研究进展

doi:10.13591/j.cnki.kqyx.2023.06.012

Abstract

Abstract:

Fusobacterium nucleatum(Fn), as the resident flora of human oral microecology, has been proved to be the main pathogen of periodontitis, participating in the occurrence and development of periodontal disease. In recent years, a large amount of evidence shows that the increase of Fn load is closely related to the development and prognosis of oral squamous cell carcinoma(OSCC). Fn may promote the occurrence and development of OSCC by enhancing tumor cell proliferation, invasion and migration ability and drug resistance. In addition, the targeted therapy targeting at Fn provides a new idea for the prevention and treatment of OSCC. In this paper, the potential mechanism of Fn promoting the occurrence and development of OSCC is reviewed, and the Fn targeted therapy of OSCC is summarized and prospected, so as to provide a new theoretical basis for the prevention and treatment of OSCC.

Key words: Fusobacterium nucleatum, oral squamous cell carcinoma, proliferation, invasion and migration, drug resistance

CLC Number:

R739.85

XU Yiping, HUANG Jialing, LIU Zhongbin, YANG Kun, GE Song. Research progress of the relationship between Fusobacterium nucleatum and oral squamous cell carcinoma[J]. Stomatology, 2023, 43(6): 546-551.

Figures/Tables 1

References 52

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Research progress of the relationship between Fusobacterium nucleatum and oral squamous cell carcinoma

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