口腔医学 ›› 2023, Vol. 43 ›› Issue (6): 546-551.doi: 10.13591/j.cnki.kqyx.2023.06.012
修回日期:
2023-01-10
出版日期:
2023-06-28
发布日期:
2023-07-06
通讯作者:
葛 颂 E-mail:基金资助:
XU Yiping1,HUANG Jialing1,LIU Zhongbin1,YANG Kun2,GE Song2()
Revised:
2023-01-10
Online:
2023-06-28
Published:
2023-07-06
摘要:
具核梭杆菌(Fusobacterium nucleatum,Fn)作为人类口腔微生态的常驻菌群,已被证实为牙周炎的主要致病菌,参与牙周病的发生发展。近年来,大量证据表明,Fn负载的增加与口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的发展和预后关系密切。Fn可能通过增强肿瘤细胞增殖、侵袭迁移能力及耐药性等多种肿瘤生物学特性,促进OSCC的发生发展。此外,以Fn为靶标的靶向治疗策略为OSCC的防治提供了新思路。本文综述了Fn促进OSCC发生发展相关的潜在机制,并对OSCC的Fn靶向治疗进行总结与展望,以期为OSCC的防治提供新的理论基础。
中图分类号:
徐依萍, 黄嘉玲, 刘忠斌, 杨琨, 葛颂. 具核梭杆菌与口腔鳞状细胞癌关系的研究进展[J]. 口腔医学, 2023, 43(6): 546-551.
XU Yiping, HUANG Jialing, LIU Zhongbin, YANG Kun, GE Song. Research progress of the relationship between Fusobacterium nucleatum and oral squamous cell carcinoma[J]. Stomatology, 2023, 43(6): 546-551.
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