lncRNA UCA1在口腔鳞状细胞癌中的研究进展

doi:10.13591/j.cnki.kqyx.2025.04.015

摘要/Abstract

摘要：

口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是最高发的头颈部恶性肿瘤,其发病率和死亡率仍然较高。长链非编码RNA(long non-coding RNA,lncRNA)是一类重要的非编码RNA分子,在OSCC的发生和发展中发挥着重要作用。尿路上皮癌抗原1(urothelial carcinoma associated 1,UCA1)在OSCC中高水平表达,通过miRNA的海绵作用以及激活下游信号通路调节肿瘤细胞的生物学行为。本文综述了UCA1在OSCC中的作用机制及其在肿瘤增殖、侵袭转移、耐药、诊断、治疗及预后等方面的研究进展,这有望为UCA1在OSCC的潜在临床应用提供理论基础。

关键词: 口腔鳞状细胞癌, lncRNA UCA1, 致癌作用, 诊断和预后, 肿瘤治疗

Abstract:

Oral squamous cell carcinoma(OSCC) is the most prevalent malignant tumor in the head and neck region, with a relatively high incidence and mortality rate. Long non-coding RNA(lncRNA) is an important class of non-coding RNA molecules that play a crucial role in the occurrence and progression of OSCC. Urothelial carcinoma associated 1(UCA1) is highly expressed in OSCC, where it regulates the biological behavior of tumor cells through miRNA sponge activity and activation of downstream signaling pathways. This article reviews the mechanisms of action of UCA1 in OSCC and its research progress in areas such as tumor proliferation, invasion, metastasis, drug resistance, diagnosis, treatment and prognosis. This is expected to provide a theoretical foundation for the potential clinical applications of UCA1 in OSCC.

Key words: oral squamous cell carcinoma, lncRNA UCA1, carcinogenesis, diagnosis and prognosis, tumor treatment

中图分类号:

R782
R739.8

陈玥, 孙雪倩, 陈敏敏. lncRNA UCA1在口腔鳞状细胞癌中的研究进展[J]. 口腔医学, 2025, 45(4): 317-320.

CHEN Yue, SUN Xueqian, CHEN Minmin. Research progress of lncRNA UCA1 in oral squamous cell carcinoma[J]. Stomatology, 2025, 45(4): 317-320.

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