NF-κB信号通路在口腔鳞状细胞癌中作用的研究进展

doi:10.13591/j.cnki.kqyx.2025.12.013

摘要/Abstract

摘要：

口腔癌是最常见的恶性肿瘤之一,其中约90%为鳞状细胞癌(OSCC)。该病生长迅速,浸润性强,复发率高且易转移,严重威胁着人类健康。近年来研究表明,NF-κB信号通路的异常激活与OSCC的发生发展密切相关。本文探讨了NF-κB信号通路在口腔鳞癌中的多途径调控作用,包括影响炎症反应、细胞增殖、凋亡、侵袭转移及耐药等,并分析了针对NF-κB信号通路作为潜在治疗靶点的OSCC治疗策略与药物开发前景。

关键词: 口腔鳞状细胞癌, NF-κB信号通路, 恶性肿瘤

Abstract:

Oral cancer is one of the most prevalent malignancies, with approximately 90% of cases being oral squamous cell carcinoma(OSCC), which exhibits rapid growth, strong infiltrative ability, high recurrence rates, and a propensity for metastasis, posing a severe threat to human health. Emerging evidence indicates that aberrant activation of the NF-κB signaling pathway is closely associated with the pathogenesis and progression of OSCC. This article delves into the multifaceted regulatory roles of the NF-κB signaling pathway in OSCC, encompassing its influence on inflammatory responses, cell proliferation, apoptosis, invasion, metastasis, and drug resistance. Furthermore, it analyzes the therapeutic strategies and drug development prospects for OSCC treatment with the NF-κB signaling pathway as a potential therapeutic target.

Key words: oral squamous cell carcinoma, NF-κB signaling pathway, malignant neoplasms

中图分类号:

R739.85

陈睿业, 刘懿卿, 张鹭, 陈宇钊, 邱峰. NF-κB信号通路在口腔鳞状细胞癌中作用的研究进展[J]. 口腔医学, 2025, 45(12): 951-955.

CHEN Ruiye, LIU Yiqing, ZHANG Lu, CHEN Yuzhao, QIU Feng. Research progress of the role of NF-κB signaling pathway in oral squamous cell carcinoma[J]. Stomatology, 2025, 45(12): 951-955.

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