口腔医学 ›› 2026, Vol. 46 ›› Issue (1): 7-13.doi: 10.13591/j.cnki.kqyx.2026.01.002
收稿日期:2025-10-15
出版日期:2026-01-28
发布日期:2026-01-16
通讯作者:
段小红
E-mail:xhduan@fmmu.edu.cn
作者简介:段小红,空军军医大学口腔医院教授、主任医师、博士研究生导师。兼任中华口腔医学会第六届理事会常务理事、口腔遗传病与罕见病专委会创会主任委员、口腔生物医学专业委员会常委,中华医学会医学遗传学专委会生化与代谢学组副组长。牵头创建国内首个口腔遗传病与罕见病门诊、生物样本库、中英文咨询网以及口腔遗传病与罕见病检索系统,牵头起草我国《口腔罕见病名录》(第一版、第二版),独著首部《口腔遗传病学》,创建国家一流课程《口腔遗传病学》、国家研究生示范课《口腔生物学理论与实践》等6门优质课程;先后主持20余项国家及省部级课题,发表中英文文章180余篇,以第一完成人获得陕西省教学成果奖一等奖等奖项。
基金资助:
XU Taoyun1,2, DUAN Xiaohong2(
)
Received:2025-10-15
Online:2026-01-28
Published:2026-01-16
Contact:
DUAN Xiaohong
E-mail:xhduan@fmmu.edu.cn
摘要:
先天缺牙是指遗传和环境等因素导致的牙齿先天缺失,是最常见的先天性口腔疾病之一,临床上主要通过口腔检查及影像学检查确诊。先天缺牙特别是多数牙缺失和全口无牙严重影响患者的咀嚼功能、颌面部发育及心理健康,由于其治疗周期长、花费高,给患者带来严重的心理和经济负担。本文系统梳理先天缺牙的诊断标准、病因机制、临床特征,重点阐述多学科序列治疗策略:儿童期以可摘义齿修复为主,侧重乳牙保护与功能引导;青少年期通过正畸治疗调整咬合、优化间隙,为后续修复奠定基础;成年期采用以种植修复为核心的多种修复方式,最终实现功能与美学的双重恢复。并进一步分析当前技术难点,展望数字化与再生医学的应用方向,为临床制定个性化方案提供参考。
中图分类号:
许涛云, 段小红. 多视角下的先天缺牙:从诊断到治疗[J]. 口腔医学, 2026, 46(1): 7-13.
XU Taoyun, DUAN Xiaohong. Tooth agenesis from a multi-perspective view: From diagnosis to treatment[J]. Stomatology, 2026, 46(1): 7-13.
| [1] | Cobourne MT. Orthodontic management of the developing dentition: An evidence-based guide[M]. Cham: Springer International Publishing, 2017. |
| [2] | 段小红. 口腔罕见病名录(第一版)[J]. 中华口腔医学杂志, 2020, 55(7): 494-500. |
| [3] |
Meade MJ, Dreyer CW. Tooth agenesis: An overview of diagnosis, aetiology and management[J]. Jpn Dent Sci Rev, 2023, 59: 209-218.
doi: 10.1016/j.jdsr.2023.07.001 |
| [4] |
Breeze J, Dover MS, Williams RW. Contemporary surgical management of hypodontia[J]. Br J Oral Maxillofac Surg, 2017, 55(5): 454-460.
doi: S0266-4356(17)30100-6 pmid: 28410841 |
| [5] |
Lai PY, Seow WK. A controlled study of the association of various dental anomalies with hypodontia of permanent teeth[J]. Pediatr Dent, 1989, 11(4): 291-296.
pmid: 2639323 |
| [6] |
Hassan SJ, Lappalainen OP, Marleena OA, et al. Implant treatment modalities of non-syndromic congenitally missing premolars: A retrospective case series of 74 specialist care patients over an 11-year-cohort[J]. Acta Odontol Scand, 2025, 84: 528-534.
doi: 10.2340/aos.v84.44657 pmid: 40905515 |
| [7] | Al-Ani AH, Antoun JS, Thomson WM, et al. Hypodontia: An update on its etiology, classification, and clinical management[J]. Biomed Res Int, 2017, 2017: 9378325. |
| [8] |
Mattheeuws N, Dermaut L, Martens G. Has hypodontia increased in Caucasians during the 20th century?A meta-analysis[J]. Eur J Orthod, 2004, 26(1): 99-103.
doi: 10.1093/ejo/26.1.99 |
| [9] |
Matalova E, Fleischmannova J, Sharpe PT, et al. Tooth agenesis: From molecular genetics to molecular dentistry[J]. J Dent Res, 2008, 87(7): 617-623.
doi: 10.1177/154405910808700715 pmid: 18573979 |
| [10] |
Polder BJ, Van’t Hof MA, Van der Linden FPGM, et al. A meta-analysis of the prevalence of dental agenesis of permanent teeth[J]. Community Dent Oral Epidemiol, 2004, 32(3): 217-226.
doi: 10.1111/com.2004.32.issue-3 |
| [11] |
Khalaf K, Miskelly J, Voge E, et al. Prevalence of hypodontia and associated factors: A systematic review and meta-analysis[J]. J Orthod, 2014, 41(4): 299-316.
doi: 10.1179/1465313314Y.0000000116 pmid: 25404667 |
| [12] | Rakhshan V. Meta-analysis of observational studies on the most commonly missing permanent dentition(excluding the third molars)in non-syndromic dental patients or randomly-selected subjects, and the factors affecting the observed rates[J]. J Clin Pediatr Dent, 2015, 39(3): 199-207. |
| [13] | 许涛云, 郭新月, 段小红, 等. WNT10A基因突变导致非综合征型先天缺牙的表型与基因型分析[J]. 口腔生物医学, 2024, 15(4): 206-211. |
| [14] | 束丽红, 唐子春, 汪海霞, 等. 非综合征型多数恒牙先天缺失的临床表型研究[J]. 华西口腔医学杂志, 2024, 42(1): 89-96. |
| [15] |
Stockton DW, Das P, Goldenberg M, et al. Mutation of PAX9 is associated with oligodontia[J]. Nat Genet, 2000, 24(1): 18-19.
doi: 10.1038/71634 pmid: 10615120 |
| [16] |
Zhou MQ, Zhang H, Camhi H, et al. Correction: Analyses of oligodontia phenotypes and genetic etiologies[J]. Int J Oral Sci, 2021, 13(1): 35.
doi: 10.1038/s41368-021-00141-5 pmid: 34772917 |
| [17] | 郭新月, 许涛云, 段小红. EDA变异导致选择性先天缺牙的表型分析[J]. 实用口腔医学杂志, 2024, 40(1): 71-75. |
| [18] |
Vastardis H. The genetics of human tooth agenesis: New discoveries for understanding dental anomalies[J]. Am J Orthod Dentofacial Orthop, 2000, 117(6): 650-656.
doi: 10.1016/S0889-5406(00)70173-9 |
| [19] |
Guo XY, Xu TY, Duan XH. Genetic-environmental risk factors for tooth agenesis: A familial case-control study in China[J]. Int Dent J, 2025, 75(5): 100956.
doi: 10.1016/j.identj.2025.100956 |
| [20] | 冯海兰. 多数牙齿先天缺失患者的口腔修复特点及治疗要点[J]. 口腔颌面修复学杂志, 2023, 24(4): 241-245. |
| [21] |
Chung CJ, Han JH, Kim KH. The pattern and prevalence of hypodontia in Koreans[J]. Oral Dis, 2008, 14(7): 620-625.
doi: 10.1111/j.1601-0825.2007.01434.x pmid: 18248591 |
| [22] |
Acharya PN, Jones SP, Moles D, et al. A cephalometric study to investigate the skeletal relationships in patients with increasing severity of hypodontia[J]. Angle Orthod, 2010, 80(4): 511-518.
doi: 10.2319/072309-411.1 pmid: 20482356 |
| [23] |
Worsaae N, Jensen BN, Holm B, et al. Treatment of severe hypodontia-oligodontia: An interdisciplinary concept[J]. Int J Oral Maxillofac Surg, 2007, 36(6): 473-480.
doi: 10.1016/j.ijom.2007.01.021 |
| [24] | 吴轶群, 王凤. 先天缺牙患者的种植治疗[J]. 中国口腔种植学杂志, 2024, 29(3): 204-211. |
| [25] |
Ye XQ, Attaie AB. Geneticbasis of nonsyndromic and syndromic tooth agenesis[J]. J Pediatr Genet, 2016, 5(4): 198-208.
doi: 10.1055/s-0036-1592421 |
| [26] |
Wang J, Sun K, Shen Y, et al. DNA methylation is critical for tooth agenesis: Implications for sporadic non-syndromic Anodontia and hypodontia[J]. Sci Rep, 2016, 6: 19162.
doi: 10.1038/srep19162 pmid: 26759063 |
| [27] | Letra A, Chiquet B, Hansen-Kiss E, et al. Nonsyndromic tooth agenesis overview[J]. 1993: NBK572295. |
| [28] |
Yu M, Wong SW, Han D, et al. Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis[J]. Oral Dis, 2019, 25(3): 646-651.
doi: 10.1111/odi.12931 pmid: 29969831 |
| [29] |
Yin W, Bian Z. The gene network underlying hypodontia[J]. J Dent Res, 2015, 94(7): 878-885.
doi: 10.1177/0022034515583999 pmid: 25910507 |
| [30] |
Chen JW, Sun TY, You Y, et al. Genome-wide identification of potential odontogenic genes involved in the dental epithelium-mesenchymal interaction during early odontogenesis[J]. BMC Genomics, 2023, 24(1): 163.
doi: 10.1186/s12864-023-09140-8 pmid: 37013486 |
| [31] |
Cameron J, Sampson WJ. Hypodontia of the permanent dentition. Case reports[J]. Aust Dent J, 1996, 41(1): 1-5.
pmid: 8639107 |
| [32] |
Gilbert-Barness E. Teratogenic causes of malformations[J]. Ann Clin Lab Sci, 2010, 40(2): 99-114.
pmid: 20421621 |
| [33] |
Al-Ani AH, Antoun JS, Thomson WM, et al. Maternal smoking during pregnancy is associated with offspring hypodontia[J]. J Dent Res, 2017, 96(9): 1014-1019.
doi: 10.1177/0022034517711156 pmid: 28535361 |
| [34] |
Kang JN, Unnai Yasuda Y, Ogawa T, et al. Association between maternal smoking during pregnancy and missing teeth in adolescents[J]. Int J Environ Res Public Health, 2019, 16(22): 4536.
doi: 10.3390/ijerph16224536 |
| [35] |
Sonis AL, Tarbell N, Valachovic RW, et al. Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities[J]. Cancer, 1990, 66(12): 2645-2652.
doi: 10.1002/1097-0142(19901215)66:12<2645::aid-cncr2820661230>3.0.co;2-s pmid: 2249205 |
| [36] | Krasuska-Sławińska E, Brożyna A, Dembowska-Bagińska B, et al. Antineoplastic chemotherapy and congenital tooth abnormalities in children and adolescents[J]. Contemp Oncol(Pozn), 2016, 20(5): 394-401. |
| [37] |
Galluccio G, Castellano M, La Monaca C. Genetic basis of non-syndromic anomalies of human tooth number[J]. Arch Oral Biol, 2012, 57(7): 918-930.
doi: 10.1016/j.archoralbio.2012.01.005 pmid: 22325622 |
| [38] |
Svinhufvud E, Myllärniemi S, Norio R. Dominant inheritance of tooth malpositionsand their association to hypodontia[J]. Clin Genet, 1988, 34(6): 373-381.
doi: 10.1111/j.1399-0004.1988.tb02895.x pmid: 3233785 |
| [39] |
Johal A, Huang Y, Toledano S. Hypodontia and its impact on a young person’s quality of life, esthetics, and self-esteem[J]. Am J Orthod Dentofacial Orthop, 2022, 161(2): 220-227.
doi: 10.1016/j.ajodo.2020.07.039 |
| [40] |
Terheyden H, Wüsthoff F. Occlusal rehabilitation in patients with congenitally missing teeth-dental implants, conventional prosthetics, tooth autotransplants, and preservation of deciduous teeth-a systematic review[J]. Int J Implant Dent, 2015, 1(1): 30.
doi: 10.1186/s40729-015-0025-z pmid: 27747652 |
| [41] |
Nunn JH, Carter NE, Gillgrass TJ, et al. The interdisciplinary management of hypodontia: Background and role of paediatric dentistry[J]. Br Dent J, 2003, 194(5): 245-251.
doi: 10.1038/sj.bdj.4809925 |
| [42] |
Haselden K, Hobkirk JA, Goodman JR, et al. Root resorption in retained deciduous canine and molar teeth without permanent successors in patients with severe hypodontia[J]. Int J Paediatr Dent, 2001, 11(3): 171-178.
pmid: 11484466 |
| [43] |
Laverty DP, Fairbrother K, Addison O. The current evidence on retaining or prosthodontically replacing retained deciduous teeth in the adult hypodontia patient: A systematic review[J]. Eur J Prosthodont Restor Dent, 2018, 26(1): 2-15.
doi: 10.1922/EJPRD_01721Laverty14 pmid: 29461745 |
| [44] |
Durey K, Cook P, Chan M. The management of severe hypodontia. Part 1: Considerations and conventional restorative options[J]. Br Dent J, 2014, 216(1): 25-29.
doi: 10.1038/sj.bdj.2013.1236 |
| [45] |
Wang Y, He J, Decker AM, et al. Clinical outcomes of implant therapy in ectodermal dysplasia patients: A systematic review[J]. Int J Oral Maxillofac Surg, 2016, 45(8): 1035-1043.
doi: 10.1016/j.ijom.2016.03.011 |
| [46] |
Kokich V. Early management of congenitally missing teeth[J]. Semin Orthod, 2005, 11(3): 146-151.
doi: 10.1053/j.sodo.2005.04.008 |
| [47] |
Santos Silveira G, de Almeida NV, Pereira DMT, et al. Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review[J]. Am J Orthod Dentofacial Orthop, 2016, 150(2): 228-237.
doi: 10.1016/j.ajodo.2016.01.018 |
| [48] |
Robertsson S. The congenitally missing upper lateral incisor. A retrospective study of orthodontic space closure versus restorative treatment[J]. Eur J Orthod, 2000, 22(6): 697-710.
doi: 10.1093/ejo/22.6.697 |
| [49] |
Carter NE, Gillgrass TJ, Hobson RS, et al. The interdisciplinary management of hypodontia: Orthodontics[J]. Br Dent J, 2003, 194(7): 361-366.
doi: 10.1038/sj.bdj.4809995 |
| [50] |
Chung LK, Hobson RS, Nunn JH, et al. An analysis of the skeletal relationships in a group of young people with hypodontia[J]. J Orthod, 2000, 27(4): 315-318.
pmid: 11099569 |
| [51] | Rachmiel A, Turgeman S, Emodi O, et al. Management of severely atrophic maxilla in ectrodactyly ectodermal dysplasia-cleft syndrome[J]. Plast Reconstr Surg Glob Open, 2018, 6(2): e1678. |
| [52] | Park SY, Choi SC, Choi BJ, et al. The autotransplantation and orthodontic treatment of multiple congenitally missing and impacted teeth[J]. J Clin Pediatr Dent, 2012, 36(4): 329-334. |
| [53] |
Alraheam IA, Ngoc CN, Wiesen CA, et al. Five-year success rate of resin-bonded fixed partial dentures: A systematic review[J]. J Esthet Restor Dent, 2019, 31(1): 40-50.
doi: 10.1111/jerd.12431 pmid: 30302909 |
| [54] |
Kutkut A, Bertoli E, Frazer R, et al. A systematic review of studies comparing conventional complete denture and implant retained overdenture[J]. J Prosthodont Res, 2018, 62(1): 1-9.
doi: S1883-1958(17)30068-3 pmid: 28666845 |
| [55] |
Budtz-Jörgensen E. Effects of denture-wearing habits on periodontal health of abutment teeth in patients with overdentures[J]. J Clin Periodontol, 1994, 21(4): 265-269.
pmid: 8195443 |
| [56] |
Branzén M, Eliasson A, Arnrup K, et al. Implant-supported single crowns replacing congenitally missing maxillary lateral incisors: A 5-year follow-up[J]. Clin Implant Dent Relat Res, 2015, 17(6): 1134-1140.
doi: 10.1111/cid.2015.17.issue-6 |
| [57] | Casaña-Ruiz MD, Català-Pizarro M, Borrás-Aviñó C, et al. Implants as a treatment alternative in children with multiple agnesia: Systematic review and meta-analysis[J]. J Clin Exp Dent, 2023, 15(4): e324-e337. |
| [58] |
Attia S, Schaaf H, El Khassawna T, et al. Oral rehabilitation of hypodontia patients using an endosseous dental implant: Functional and aesthetic results[J]. J Clin Med, 2019, 8(10): 1687.
doi: 10.3390/jcm8101687 |
| [59] | Thuaire A, Nicot R, Raoul G, et al. Surgical bone augmentation procedures for oral rehabilitation of patients with oligodontia: A review with a systematic approach[J]. J Stomatol Oral Maxillofac Surg, 2023, 124(1S): 101370. |
| [60] |
Sun XD, Yang J, Ma XL, et al. Complex rehabilitation for an adolescent with ectodermal dysplasia-a 10-year follow-up[J]. J Prosthodont, 2021, 30(1): 7-12.
doi: 10.1111/jopr.v30.1 |
| [61] | Wu YQ, Wang XD, Wang F, et al. Restoration of oral function for adult edentulous patients with ectodermal dysplasia: A prospective preliminary clinical study[J]. Clin Implant Dent Relat Res, 2015, 17(Suppl 2): e633-642. |
| [62] |
Goker F, Grecchi E, Mancini EG, et al. Zygomatic implant survival in 9 ectodermal dysplasia patients with 3.5- to 7-year follow-up[J]. Oral Dis, 2020, 26(8): 1803-1809.
doi: 10.1111/odi.v26.8 |
| [63] |
King P, Maiorana C, Luthardt RG, et al. Clinical and radiographic evaluation of a small-diameter dental implant used for the restoration of patients with permanent tooth agenesis(hypodontia) in the maxillary lateral incisor and mandibular incisor regions: A 36-month follow-up[J]. Int J Prosthodont, 2016, 29(2): 147-153.
doi: 10.11607/ijp.4444 |
| [64] |
Thoma DS, Cosyn J, Fickl S, et al. Soft tissue management at implants: Summary and consensus statements of group 2. The 6th EAO Consensus Conference 2021[J]. Clin Oral Implants Res, 2021, 32(Suppl 21): 174-180.
doi: 10.1111/clr.v32.s21 |
| [65] |
Cerezo-Cayuelas M, Pérez-Silva A, Serna-Muñoz C, et al. Orthodontic and dentofacial orthopedic treatments in patients with ectodermal dysplasia: A systematic review[J]. Orphanet J Rare Dis, 2022, 17(1): 376.
doi: 10.1186/s13023-022-02533-0 pmid: 36253866 |
| [66] |
Bergendal B, Bjerklin K, Bergendal T, et al. Dental implant therapy for a child with X-linked hypohidrotic ectodermal dysplasia: Three decades of managed care[J]. Int J Prosthodont, 2015, 28(4): 348-356.
doi: 10.11607/ijp.4242 pmid: 26218015 |
| [67] |
Roccuzzo A, Imber JC, Jensen SS. Need for lateral bone augmentation at two narrow-diameter implants: A prospective, controlled, clinical study[J]. Clin Oral Implants Res, 2021, 32(4): 511-520.
doi: 10.1111/clr.v32.4 |
| [68] |
Filius MAP, Vissink A, Cune MS, et al. Long-term implant performance and patients’ satisfaction in oligodontia[J]. J Dent, 2018, 71: 18-24.
doi: 10.1016/j.jdent.2018.01.007 |
| [69] |
Chrcanovic BR. Dental implants in patients with ectodermal dysplasia: A systematic review[J]. J Craniomaxillofac Surg, 2018, 46(8): 1211-1217.
doi: S1010-5182(18)30286-5 pmid: 29884311 |
| [70] |
Murdock S, Lee JY, Guckes A, et al. A costs analysis of dental treatment for ectodermal dysplasia[J]. J Am Dent Assoc, 2005, 136(9): 1273-1276.
doi: 10.14219/jada.archive.2005.0343 pmid: 16196232 |
| [71] | Doh RM, Dam C, Kyung KY, et al. Precise implant placement with a computer-assisted surgical guide in cleft lip and palate patients[J]. Cleft Palate Craniofac J, 2015, 52(3): e65-71. |
| [72] |
Yu XB, Tao BX, Wang F, et al. Accuracy assessment of dynamic navigation during implant placement: A systematic review and meta-analysis of clinical studies in the last 10 years[J]. J Dent, 2023, 135: 104567.
doi: 10.1016/j.jdent.2023.104567 |
| [73] |
Orban K, Varga E Jr, Windisch P, et al. Accuracy of half-guided implant placement with machine-driven or manual insertion: A prospective, randomized clinical study[J]. Clin Oral Investig, 2022, 26(1): 1035-1043.
doi: 10.1007/s00784-021-04087-0 |
| [74] |
Blume O, Donkiewicz P, Back M, et al. Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report[J]. J Esthet Restor Dent, 2019, 31(3): 171-178.
doi: 10.1111/jerd.12454 pmid: 30756449 |
| [75] |
Schneider H, Schweikl C, Faschingbauer F, et al. A causal treatment for X-linked hypohidrotic ectodermal dysplasia: Long-term results of short-term perinatal ectodysplasin A1 replacement[J]. Int J Mol Sci, 2023, 24(8): 7155.
doi: 10.3390/ijms24087155 |
| [76] |
Takahashi K, Kiso H, Murashima-Suginami A, et al. Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy[J]. Inflamm Regen, 2020, 40: 21.
doi: 10.1186/s41232-020-00130-x pmid: 32922570 |
| [77] |
Takahashi K, Kiso H, Mihara E, et al. Development of a new antibody drug to treat congenital tooth agenesis[J]. J Oral Biosci, 2024, 66(4): 1-9.
doi: 10.1016/j.job.2024.10.002 pmid: 39389160 |
| [78] | Murashima-Suginami A, Kiso H, Tokita Y, et al. Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling[J]. Sci Adv, 2021, 7(7): eabf1798. |
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