口腔医学 ›› 2026, Vol. 46 ›› Issue (1): 7-13.doi: 10.13591/j.cnki.kqyx.2026.01.002

• 口腔遗传病和罕见病的诊治 • 上一篇    下一篇

多视角下的先天缺牙:从诊断到治疗

许涛云1,2, 段小红2()   

  1. 1 中国人民解放军92510部队,广东湛江(524086)
    2 口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔医学重点实验室,空军军医大学口腔医院口腔生物学教研室和口腔罕见病与遗传病门诊,陕西西安(710032)
  • 收稿日期:2025-10-15 出版日期:2026-01-28 发布日期:2026-01-16
  • 通讯作者: 段小红 E-mail:xhduan@fmmu.edu.cn
  • 作者简介:段小红,空军军医大学口腔医院教授、主任医师、博士研究生导师。兼任中华口腔医学会第六届理事会常务理事、口腔遗传病与罕见病专委会创会主任委员、口腔生物医学专业委员会常委,中华医学会医学遗传学专委会生化与代谢学组副组长。牵头创建国内首个口腔遗传病与罕见病门诊、生物样本库、中英文咨询网以及口腔遗传病与罕见病检索系统,牵头起草我国《口腔罕见病名录》(第一版、第二版),独著首部《口腔遗传病学》,创建国家一流课程《口腔遗传病学》、国家研究生示范课《口腔生物学理论与实践》等6门优质课程;先后主持20余项国家及省部级课题,发表中英文文章180余篇,以第一完成人获得陕西省教学成果奖一等奖等奖项。
  • 基金资助:
    国家自然科学基金(82370907);国家口腔疾病临床医学研究中心专项课题(LCC202201)

Tooth agenesis from a multi-perspective view: From diagnosis to treatment

XU Taoyun1,2, DUAN Xiaohong2()   

  1. Unit 92510 of the Chinese People’s Liberation Army, Zhanjiang 524086, China
  • Received:2025-10-15 Online:2026-01-28 Published:2026-01-16
  • Contact: DUAN Xiaohong E-mail:xhduan@fmmu.edu.cn

摘要:

先天缺牙是指遗传和环境等因素导致的牙齿先天缺失,是最常见的先天性口腔疾病之一,临床上主要通过口腔检查及影像学检查确诊。先天缺牙特别是多数牙缺失和全口无牙严重影响患者的咀嚼功能、颌面部发育及心理健康,由于其治疗周期长、花费高,给患者带来严重的心理和经济负担。本文系统梳理先天缺牙的诊断标准、病因机制、临床特征,重点阐述多学科序列治疗策略:儿童期以可摘义齿修复为主,侧重乳牙保护与功能引导;青少年期通过正畸治疗调整咬合、优化间隙,为后续修复奠定基础;成年期采用以种植修复为核心的多种修复方式,最终实现功能与美学的双重恢复。并进一步分析当前技术难点,展望数字化与再生医学的应用方向,为临床制定个性化方案提供参考。

关键词: 先天缺牙, 诊断标准, 临床特征, 多学科序列治疗, 种植修复

Abstract:

Tooth agenesis refers to the congenital absence of teeth resulting from genetic and environmental factors. As one of the most prevalent congenital oral disorders, its clinical diagnosis is primarily based on clinical oral examination and radiographic imaging. Tooth agenesis, especially oligodontia and anodontia, seriously affects patients’ masticatory function, maxillofacial development, and mental health. Due to its long treatment process and high cost, it imposes severe psychological and financial burdens on patients. This article systematically reviews the diagnostic criteria, etiological mechanisms, and clinical features of tooth agenesis, with a focus on elaborating the multidisciplinary treatment strategy. During childhood, treatment primarily involves removable denture, emphasizing the protection of deciduous teeth and functional guidance. In adolescence, orthodontic treatment is used to adjust occlusion and optimize the space, laying a foundation for subsequent restoration. And in adulthood, utilizes various restorative approaches centered on implant-supported prostheses are utilized to ultimately achieve the dual restoration of function and aesthetics. In addition, we emphasize the current technical challenges and explore the application prospects of digital technology and regenerative medicine, aiming to provide references for developing personalized clinical treatment plans.

Key words: tooth agenesis, diagnostic criteria, clinical features, multi-disciplinary treatment, implant prosthodontics

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