牙周致病菌与消化系统肿瘤相关性的研究进展

doi:10.13591/j.cnki.kqyx.2025.09.009

摘要/Abstract

摘要：

牙周炎与多种全身系统性疾病密切相关,研究报道牙周炎对消化系统肿瘤具有促进作用。牙周致病菌可通过异位定植于消化系统肿瘤部位,直接调控肿瘤细胞、塑造促炎微环境、调节免疫反应,参与肿瘤的发生和发展。该文综述了牙周致病菌在促进消化系统肿瘤中的研究进展,旨在阐明其作用机制,并为相关研究向临床转化提供参考。

关键词: 牙周炎, 消化系统肿瘤, 牙周致病菌, 肿瘤进展, 肿瘤微环境

Abstract:

Periodontitis is closely associated with various systemic diseases, and emerging studies have reported its promotive effect on gastrointestinal tumors. Periodontal pathogens can ectopically colonize tumor sites in the gastrointestinal system, directly regulate tumor cells, shape a pro-inflammatory microenvironment, and modulate immune responses, thereby promoting tumor initiation and progression. This review summarizes the research progress of periodontal pathogens in promoting gastrointestinal tumors, aiming to elucidate their underlying mechanisms and provide insights for translational research and clinical applications.

Key words: periodontitis, gastrointestinal tumors, periodontal pathogens, tumor progression, tumor microenvironment

中图分类号:

R781.4

李昊谕, 吴懿宽, 丁佩惠, 李晓军. 牙周致病菌与消化系统肿瘤相关性的研究进展[J]. 口腔医学, 2025, 45(9): 691-695.

LI Haoyu, WU Yikuan, DING Peihui, LI Xiaojun. Research progress of the correlation between periodontal pathogens and gastrointestinal tumors[J]. Stomatology, 2025, 45(9): 691-695.

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