口腔医学 ›› 2026, Vol. 46 ›› Issue (2): 152-155.doi: 10.13591/j.cnki.kqyx.2026.02.012
收稿日期:2025-03-27
出版日期:2026-02-28
发布日期:2026-03-09
通讯作者:
钟良军 Tel:(0571)88303551,E-mail:基金资助:
SHEN Weiwei1, ZHONG Liangjun1,2(
)
Received:2025-03-27
Online:2026-02-28
Published:2026-03-09
摘要:
肥胖可能增加牙周炎患病率,加重牙周组织破坏,影响牙周治疗预后。本文旨在总结肥胖相关脂肪因子、氧化应激、口腔菌群、胰岛素抵抗及精神压力变化对牙周炎的影响及潜在机制,以期为临床中综合管理肥胖牙周炎患者提供指导。
中图分类号:
沈炜炜, 钟良军. 肥胖影响牙周炎的机制研究进展[J]. 口腔医学, 2026, 46(2): 152-155.
SHEN Weiwei, ZHONG Liangjun. Progress of research on the mechanism of obesity’s impact on periodontitis[J]. Stomatology, 2026, 46(2): 152-155.
| [1] |
Villoria GEM, Fischer RG, Tinoco EMB, et al. Periodontal disease: A systemic condition[J]. Periodontol 2000, 2024, 96(1): 7-19.
doi: 10.1111/prd.12616 pmid: 39494478 |
| [2] | Zhao PF, Xu AM, Leung WK. Obesity, bone loss, and periodontitis: The interlink[J]. Biomolecules, 2022, 12(7): 865. |
| [3] | Wang LM, Zhou B, Zhao ZP, et al. Body-mass index and obesity in urban and rural China: Findings from consecutive nationally representative surveys during 2004-2018[J]. Lancet, 2021, 398(10294): 53-63. |
| [4] |
Suvan J, Petrie A, Moles DR, et al. Body mass index as a predictive factor of periodontal therapy outcomes[J]. J Dent Res, 2014, 93(1): 49-54.
doi: 10.1177/0022034513511084 pmid: 24165943 |
| [5] |
Li Y, Lu Z, Zhang X, et al. Metabolic syndrome exacerbates inflammation and bone loss in periodontitis[J]. J Dent Res, 2015, 94(2): 362-370.
doi: 10.1177/0022034514561658 pmid: 25503900 |
| [6] |
Balli U, Bozkurt Dogan S, Ongoz Dede F, et al. The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy[J]. J Oral Sci, 2016, 58(4): 465-473.
doi: 10.2334/josnusd.16-0212 pmid: 28025429 |
| [7] | Arboleda S, Vargas M, Losada S, et al. Review of obesity and periodontitis: An epidemiological view[J]. Br Dent J, 2019, 227(3): 235-239. |
| [8] |
Liu L, Xia LY, Gao YJ, et al. Association between obesity and periodontitis in US adults: NHANES 2011-2014[J]. Obes Facts, 2024, 17(1): 47-58.
doi: 10.1159/000534751 |
| [9] |
Gorman A, Kaye EK, Apovian C, et al. Overweight and obesity predict time to periodontal disease progression in men[J]. J Clin Periodontol, 2012, 39(2): 107-114.
doi: 10.1111/j.1600-051X.2011.01824.x pmid: 22150475 |
| [10] |
Foratori-Junior GA, Mosquim V, Buzalaf MAR, et al. Salivary cytokines levels, maternal periodontitis and infants’ weight at birth: A cohort study in pregnant women with obesity[J]. Placenta, 2021, 115: 151-157.
doi: 10.1016/j.placenta.2021.09.018 pmid: 34628311 |
| [11] |
Ylöstalo P, Suominen-Taipale L, Reunanen A, et al. Association between body weight and periodontal infection[J]. J Clin Periodontol, 2008, 35(4): 297-304.
doi: 10.1111/j.1600-051X.2008.01203.x pmid: 18294226 |
| [12] |
Abuohashish H, Omar O, Alrayes N, et al. Exacerbating effects of Western dietary habits on experimentally induced periodontitis in rats[J]. Odontology, 2025, 113(3): 1204-1219.
doi: 10.1007/s10266-025-01067-8 pmid: 39937328 |
| [13] | Khocht A, Bellinger D, Lenoir L, et al. Obesity is associated with a weakened gingival inflammatory cytokine response[J]. Medicina (Kaunas), 2023, 59(12): 2089. |
| [14] |
Zimmermann GS, Bastos MF, Dias Gonçalves TE, et al. Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis[J]. J Periodontol, 2013, 84(5): 624-633.
doi: 10.1902/jop.2012.120254 pmid: 22839694 |
| [15] |
Kwack KH, Zhang L, Sohn J, et al. Novel preosteoclast populations in obesity-associated periodontal disease[J]. J Dent Res, 2022, 101(3): 348-356.
doi: 10.1177/00220345211040729 |
| [16] |
Guo YT, Jiang SD, Li HZ, et al. Obesity induces osteoimmunology imbalance: Molecular mechanisms and clinical implications[J]. Biomed Pharmacother, 2024, 177: 117139.
doi: 10.1016/j.biopha.2024.117139 |
| [17] |
Gerber FA, Sahrmann P, Schmidlin OA, et al. Influence of obesity on the outcome of non-surgical periodontal therapy-A systematic review[J]. BMC Oral Health, 2016, 16(1): 90.
doi: 10.1186/s12903-016-0272-2 |
| [18] |
Zhang YW, Jia R, Zhang YF, et al. Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: A systematic review and meta-analysis[J]. BMC Oral Health, 2023, 23(1): 717.
doi: 10.1186/s12903-023-03383-3 pmid: 37798684 |
| [19] | Kaye E, McDonough R, Singhal A, et al. Effect of overweight and obesity on periodontal treatment intensity[J]. JDR Clin Trans Res, 2023, 8(2): 158-167. |
| [20] | Marruganti C, Suvan JE, D’Aiuto F. Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity[J]. Periodontol 2000, 2023.doi:10.1111/prd.12536. |
| [21] |
Chaudhry SZ, Ghafoor S. Adipokines: Diagnostic and prognostic markers for oral diseases[J]. J Pak Med Assoc, 2023, 73(4): 858-862.
doi: 10.47391/JPMA.4737 pmid: 37052000 |
| [22] | Checa-Ros A, Hsueh WC, Merck B, et al. Obesity and oral health: The link between adipokines and periodontitis[J]. touch REV Endocrinol, 2024, 20(1): 25-31. |
| [23] |
Han Y, Huang Y, Gao P, et al. Leptin aggravates periodontitis by promoting M1 polarization via NLRP3[J]. J Dent Res, 2022, 101(6): 675-685.
doi: 10.1177/00220345211059418 |
| [24] | Guo ZJ, Peng YH, Hu QY, et al. The relationship between leptin and periodontitis: A literature review[J]. Peer J, 2023, 11: e16633. |
| [25] | Nokhbehsaim M, Eick S, Nogueira AVB, et al. Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells[J]. Mediators Inflamm, 2013, 2013: 437123. |
| [26] |
Zhu JF, Zhang SH, Shi J, et al. Periodontitis is associated with the increased levels of visfatin: A meta-analysis[J]. BMC Oral Health, 2023, 23(1): 799.
doi: 10.1186/s12903-023-03384-2 pmid: 37884949 |
| [27] | Nogueira AVB, Nokhbehsaim M, Tekin S, et al. Resistin is increased in periodontal cells and tissues: In vitro and in vivo studies[J]. Mediators Inflamm, 2020, 2020: 9817095. |
| [28] | Wu HH, Guo Y, Pu YF, et al. Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs[J]. Biosci Rep, 2021, 41(3): BSR20192668. |
| [29] |
Yang Y, Chen LR. Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress[J]. Prostaglandins Other Lipid Mediat, 2024, 174: 106882.
doi: 10.1016/j.prostaglandins.2024.106882 |
| [30] | 闫福华. 牙周炎对全身疾病和健康影响的研究进展[J]. 口腔医学, 2018, 38(7): 577-581. |
| [31] |
de Mello AH, Costa AB, Engel JDG, et al. Mitochondrial dysfunction in obesity[J]. Life Sci, 2018, 192: 26-32.
doi: S0024-3205(17)30597-0 pmid: 29155300 |
| [32] |
Filomeni G, De Zio D, Cecconi F. Oxidative stress and autophagy: The clash between damage and metabolic needs[J]. Cell Death Differ, 2015, 22(3): 377-388.
doi: 10.1038/cdd.2014.150 pmid: 25257172 |
| [33] |
Dursun E, Akalin FA, Genc T, et al. Oxidative stress and periodontal disease in obesity[J]. Medicine (Baltimore), 2016, 95(12): e3136.
doi: 10.1097/MD.0000000000003136 |
| [34] |
Boesing F, Patiño JR, da Silva VG, et al. The interface between obesity and periodontitis with emphasis on oxidative stress and inflammatory response[J]. Obes Rev, 2009, 10(3): 290-297.
doi: 10.1111/j.1467-789X.2008.00555.x pmid: 19207875 |
| [35] |
Sczepanik FSC, Grossi ML, Casati M, et al. Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way[J]. Periodontol 2000, 2020, 84(1): 45-68.
doi: 10.1111/prd.12342 pmid: 32844417 |
| [36] |
Alarcón-Sánchez MA. Influence of obesity on subgingival microbiota composition in subjects with different periodontal status: A systematic review[J]. Rev Cient Odontol (Lima), 2024, 12(1): e187.
doi: 10.21142/2523-2754-1201-2024-187 pmid: 39015311 |
| [37] |
Bombin A, Yan S, Bombin S, et al. Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa[J]. Physiol Rep, 2022, 10(7): e15254.
doi: 10.14814/phy2.15254 |
| [38] |
Khocht A, Paster B, Lenoir L, et al. Metabolomic profiles of obesity and subgingival microbiome in periodontally healthy individuals: A cross-sectional study[J]. J Clin Periodontol, 2023, 50(11): 1455-1466.
doi: 10.1111/jcpe.13860 pmid: 37536958 |
| [39] |
Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese[J]. Biomed Pharmacother, 2021, 137: 111315.
doi: 10.1016/j.biopha.2021.111315 pmid: 33561645 |
| [40] |
Kalhan AC, Kalhan TA, Romandini M, et al. Insulin resistance and periodontitis: Mediation by blood pressure[J]. J Periodontal Res, 2025, 60(3): 226-235.
doi: 10.1111/jre.v60.3 |
| [41] | Muniyappa R, Chen H, Montagnani M, et al. Endothelial dysfunction due to selective insulin resistance in vascular endothelium: Insights from mechanistic modeling[J]. Am J Physiol Endocrinol Metab, 2020, 319(3): E629-E646. |
| [42] |
Dumitrescu AL, Kawamura M. Involvement of psychosocial factors in the association of obesity with periodontitis[J]. J Oral Sci, 2010, 52(1): 115-124.
pmid: 20339242 |
| [43] |
Gu WX, Yu XY, Tan YL, et al. Association between weight, weight perception, weight teasing and mental health among adolescents[J]. Child Adolesc Psychiatry Ment Health, 2024, 18(1): 39.
doi: 10.1186/s13034-024-00730-2 |
| [44] |
Ball J, Darby I. Mental health and periodontal and peri-implant diseases[J]. Periodontol 2000, 2022, 90(1): 106-124.
doi: 10.1111/prd.12452 pmid: 35913583 |
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