成熟恒牙牙髓再生研究进展与挑战

doi:10.13591/j.cnki.kqyx.2026.03.013

摘要/Abstract

摘要：

该文聚焦牙髓再生技术的应用从局限于年轻恒牙至拓展到成熟恒牙的转变,阐述了成熟恒牙牙髓再生的研究进展与挑战。在研究进展方面,从临床随机对照试验、系统综述和Meta分析等方面分析,均证实成熟恒牙牙髓再生技术的可行性,且成功率高。但成熟恒牙牙髓再生面临诸多挑战:如感染控制、干细胞来源及支架、生长因子来源、衰老微环境等方面。牙髓再生应用于成熟恒牙治疗极具潜力与挑战。虽前景光明,但需攻克系列难题,构建完善的标准化治疗体系,方可推动牙髓再生成为治疗成熟恒牙牙髓坏死等疾病的有效疗法。

关键词: 牙髓再生, 成熟恒牙, 牙髓干细胞, 血运重建

Abstract:

This paper focuses on the transformation of pulp regeneration technology from being limited to young permanent teeth to being extended to mature permanent teeth, and elaborates on the research progress and challenges of pulp regeneration in mature permanent teeth. In terms of research progress, through the analysis of clinical randomized controlled trials, systematic reviews and Meta-analyses, etc., it has been confirmed that the pulp regeneration technology for mature permanent teeth is feasible and has a high success rate. However, pulp regeneration in mature permanent teeth faces numerous challenges, such as infection control, sources of stem cells and scaffolds, sources of growth factors, and the aging microenvironment. Pulp regeneration holds great potential and challenges in the treatment of mature permanent teeth. Although the prospects are promising, a series of problems need to be overcome, and a sound and standardized treatment system needs to be established before pulp regeneration can be promoted as an effective treatment for diseases such as pulp necrosis of mature permanent teeth.

Key words: regenerative endodontics, permanent teeth, dental pulp stem cells, revascularization

中图分类号:

R781.3

胡龙鑫, 穆海丽, 张吉昊, 师晓蕊. 成熟恒牙牙髓再生研究进展与挑战[J]. 口腔医学, 2026, 46(3): 236-240.

HU Longxin, MU Haili, ZHANG Jihao, SHI Xiaorui. Research progress and challenges of pulp regeneration in mature permanent teeth[J]. Stomatology, 2026, 46(3): 236-240.

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