5-羟色胺与口腔扁平苔藓的相关性研究进展

doi:10.13591/j.cnki.kqyx.2023.04.013

Abstract

Abstract:

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease. The existing literature shows that psychological factors are one of the important pathogenic factors. At the same time, OLP is an autoimmune disease caused by immune dysregulation. We suspect that psychological factors may cause immune dysregulation through the chemical reaction of some factors and local immunity in the pathogenesis of OLP. 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter, which can be used as a mediator of bilateral contact between the nervous system and the immune system. 5-HT may activate different signaling pathways through binding with multiple receptors, and it plays an important role in regulating emotion regulation and the proliferation, migration and apoptosis of immune cells. Recent studies have shown that 5-HT may be involved in the occurrence and development of OLP. This paper will review the function of 5-HT and its receptors, their specific expression in autoimmune diseases and their possible roles in OLP.

Key words: 5-hydroxytryptamine, oral lichen planus, psychological factor, immune factor

CLC Number:

R781.59

WANG Qian,ZHANG Dongqing,ZHANG Songwei,ZHAN Yuanbo,MU Sen. Research progress of the correlation between 5-hydroxytryptamine and oral lichen planus[J]. Stomatology, 2023, 43(4): 353-358.

Figures/Tables 1

References 52

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免疫细胞	受体类型	主要功能
T淋巴细胞	5-HT_1A	T细胞增殖
	5-HT_1B
	5-HT₃
	5-HT_2A	T细胞活化
	5-HT₇	T细胞活化
树突状细胞(未成熟)	5-HT_1B	趋化作用,调节细胞内Ca²⁺浓度
	5-HT_1E
	5-HT_2A
	5-HT_2B
树突状细胞(成熟)	5-HT₄	影响细胞因子分泌
树突状细胞(成熟)	5-HT₇	影响细胞因子分泌
肥大细胞	5-HT_1A	趋化作用
巨噬细胞	5-HT_1A	上调活性
单核细胞	5-HT_1A	抑制H₂O₂的释放,促进炎症

Research progress of the correlation between 5-hydroxytryptamine and oral lichen planus

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