Abstract:

Periodontitis is considered to be a destructive periodontal disease caused by periodontal pathogens, which eventually leads to tooth loss through the destruction of periodontal tissue. As one of the important trace elements in human body, iron participates in various physiological activities of the body. Iron metabolism balance is an important part in maintaining the physiological function and its metabolic abnormality is associated with various diseases. Dysregulation of iron homeostasis can promote the increase of reactive oxygen species(ROS) level and destroy the balance between oxidative and antioxidant defense systems, thus leading to oxidative stress, further damaging the periodontal tissue and increasing the incidence of periodontitis. Several studies have shown that there is a certain relationship between abnormal iron metabolism and the occurrence and development of periodontitis, which affects the course and prognosis of periodontitis. This article reviews the research progress of ROS-induced oxidative stress and the mechanism of iron metabolism in periodontitis, and provides new ideas for the prevention and treatment of periodontitis from the direction of iron metabolism.

Key words: periodontitis, reactive oxygen species, oxidative stress, iron metabolism