Stomatology ›› 2024, Vol. 44 ›› Issue (9): 641-647.doi: 10.13591/j.cnki.kqyx.2024.09.001

• Review and Commentary •     Next Articles

Potential application of framework nucleic acids in stomatology

LI Jiajie1,LIN Yunfeng2,3,4()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Plastic Surgery and Cosmetic Dermatology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-03-14 Online:2024-09-28 Published:2024-09-10

Abstract:

As the simplest type of DNA polyhedron, tetrahedral framework nucleic acids(tFNAs)gradually show their potential in stomatology. tFNAs continue to attract attention due to their excellent endocytosis ability, tissue permeability, strong editability, and predictability. This article summarizes the relevant literature, discussing the advantages of tFNAs in preparation and biological behavior regulation. It focuses on the latest research progress and potential application value of framework nucleic acids in stomatology. It provides a theoretical basis for future nucleic acid drugs to achieve broader clinical applications.

Key words: tetrahedral framework nucleic acids, nucleic acid drugs, stomatology, preclinical applications

CLC Number: