多不饱和脂肪酸代谢产物在口腔疾病中的作用及应用研究进展

doi:10.13591/j.cnki.kqyx.2024.07.011

Abstract

Abstract:

This review aims to explore research progress ofthe role and application of polyunsaturated fatty acid (PUFA) metabolites in oral diseases. We first briefly review the metabolic pathways and key enzymes of PUFAs, as well as their biological functions. Then, we discuss in detail the role of PUFA metabolites in various oral diseases, including oral mucosal diseases, periodontal diseases, dental and pulp diseases, oral cancer, and temporomandibular joint disorders (TMD). Studies have shown that PUFA metabolites play an important role in regulating inflammation, immune responses, and tissue repair, and are closely involved in the development and progression of oral diseases. Moreover, PUFA metabolites have potential application value in the diagnosis, treatment, and prevention of oral diseases. Therefore, research on the role and application of PUFA metabolites in oral diseases will help deepen our understanding of the pathogenesis of oral diseases and provide new ideas and methods for clinical treatment of oral diseases.

Key words: polyunsaturated fatty acid, periodontitis, oral disease, pulpitis, oral mucosal diseases

CLC Number:

R344.1

XU Huaxing, WEI Xiaoling. Research progress of the role and application of polyunsaturated fatty acid metabolites in oral diseases[J]. Stomatology, 2024, 44(7): 545-550.

References 54

[1]	Kassebaum NJ, Bernabé E, Dahiya M, et al. Global burden of severe periodontitis in 1990-2010: A systematic review and meta-regression[J]. J Dent Res, 2014, 93(11): 1045-1053. doi: 10.1177/0022034514552491 pmid: 25261053
[2]	Warner DR, Warner JB, Hardesty JE, et al. Decreased ω-6: ω-3 PUFA ratio attenuates ethanol⁃induced alterations in intestinal homeostasis, microbiota, and liver injury[J]. J Lipid Res, 2019, 60(12): 2034-2049.
[3]	周子超, 孙梦君, 束蓉. DHA和EPA在牙周炎中的研究进展[J]. 口腔医学, 2015, 35(5):408-411.
[4]	Azuma MM, Cardoso CBM, da Silva CC, et al. The use of omega-3 fatty acids in the treatment of oral diseases[J]. Oral Dis, 2022, 28(2): 264-274.
[5]	Schulze MB, Minihane AM, Saleh RNM, et al. Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: Nutritional implications for cardiometabolic diseases[J]. Lancet Diabetes Endocrinol, 2020, 8(11): 915-930.
[6]	Furse S, Virtue S, Snowden SG, et al. Dietary PUFAs drive diverse system-level changes in lipid metabolism[J]. Mol Metab, 2022, 59: 101457.
[7]	曹野, 王伟琼, 陈晨, 等. ω-3多不饱和脂肪酸的结构、代谢及与动脉粥样硬化的关系[J]. 中国动脉硬化杂志, 2018, 26(6): 633-643.
[8]	孙桂菊, 柳和春, 许登峰, 等. n-3多不饱和脂肪酸的抗炎作用和2型糖尿病[J]. 健康教育与健康促进, 2020, 15(2): 116-119.
[9]	李玥. DHA与EPA对大鼠骨关节炎发病的影响及作用机理的研究[D]. 哈尔滨: 东北农业大学, 2021.
[10]	Jiang L, Wang JY, Xiong K, et al. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of cardiovascular disease mortality: A meta-analysis of prospective cohort studies[J]. Nutrients, 2021, 13(7): 2342.
[11]	Rodríguez-Iglesias N, Nadjar A, Sierra A, et al. Susceptibility of female mice to the dietaryOmega-3/Omega-6 fatty-acid ratio: Effects on adult hippocampal neurogenesis and Glia[J]. Int J MolSci, 2022, 23(6): 3399.
[12]	其力格尔, Nawab S, 范殊璇, 等. ω-3多不饱和脂肪酸抗肿瘤新途径: 抑制具核梭杆菌黏附宿主细胞[J]. 微生物学通报, 2021, 48(3): 820-829.
[13]	Hu ZJ, Pan ZY, Dai ZT, et al. ω-6 polyunsaturated fatty acids derived lipid mediators promote colorectal cancer growth by providing an immunosuppressive microenvironment[J]. Int Immunopharmacol, 2023, 116: 109818.
[14]	Montecillo-Aguado M, Tirado-Rodriguez B, Antonio-Andres G, et al. Omega-6 polyunsaturated fatty acids enhance tumor aggressiveness in experimental lung cancer model: Important role of oxylipins[J]. Int J Mol Sci, 2022, 23(11): 6179.
[15]	Balić A, Vlašić D, Žužul K, et al. Omega-3 versus Omega-6 polyunsaturated fatty acids in the prevention and treatment of inflammatory skin diseases[J]. Int J Mol Sci, 2020, 21(3): 741.
[16]	D’Angelo S, Motti ML, Meccariello R. ω-3 and ω-6 polyunsaturated fatty acids, obesity and cancer[J]. Nutrients, 2020, 12(9): E2751.
[17]	张武霞, 庄智彬, 郭淑珍, 等. 特异性促炎症消退介质结构与功能研究进展[J]. 免疫学杂志, 2020, 36(5): 432-441.
[18]	Walker KH, Krishnamoorthy N, Brüggemann TR, et al. Protectins PCTR1 and PD1 reduce viral load and lung inflammation during respiratory syncytial virus infection in mice[J]. Front Immunol, 2021, 12: 704427.
[19]	Saito-Sasaki N, Sawada Y, Nakamura M. Maresin-1 and inflammatorydisease[J]. Int J Mol Sci, 2022, 23(3): 1367.
[20]	Dyall SC, Balas L, Bazan NG, et al. Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions[J]. Prog Lipid Res, 2022, 86: 101165.
[21]	Storniolo CE, Pequera M, Vilariño A, et al. Specialized pro-resolvin mediators induce cell growth and improve wound repair in intestinal epithelial Caco-2 cell cultures[J]. Prostaglandins Leukot Essent Fatty Acids, 2022, 187: 102520.
[22]	Tao XS, Lee MS, Donnelly CR, et al. Neuromodulation, specialized proresolving mediators, and resolution of pain[J]. Neurotherapeutics, 2020, 17(3): 886-899.
[23]	Cotti E, Ideo F, Pedrazzini A, et al. Proresolving mediators in endodontics: A systematic review[J]. J Endod, 2021, 47(5): 711-720. doi: 10.1016/j.joen.2021.01.008 pmid: 33548330
[24]	Liotti F, Marotta M, Melillo RM, et al. The impact of resolution of inflammation on tumor microenvironment: Exploring new ways to control cancer progression[J]. Cancers, 2022, 14(14): 3333.
[25]	Kim AS, Conte MS. Specialized pro-resolving lipid mediators in cardiovascular disease, diagnosis, and therapy[J]. Adv Drug Deliv Rev, 2020, 159: 170-179.
[26]	Ayub M, Jin HK, Bae JS. Sphingosine kinase-dependent regulation of pro-resolving lipid mediators in Alzheimer’s disease[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2022, 1867(5): 159126.
[27]	Livshits G, Kalinkovich A. Receptors for pro-resolving mediators as a therapeutic tool for smooth muscle remodeling-associated disorders[J]. Pharmacol Res, 2021, 164: 105340.
[28]	Xia DN, Tan YQ, Yang JY, et al. Omega-3 polyunsaturated fatty acids: A promising approach for the management of oral lichen planus[J]. Inflamm Res, 2020, 69(10): 989-999.
[29]	Castrejón-Morales CY, Granados-Portillo O, Cruz-Bautista I, et al. Omega-3 and Omega-6 fatty acids in primary Sjögren’s syndrome: Clinical meaning and association with inflammation[J]. Clin Exp Rheumatol, 2020, 126(4): 34-39.
[30]	Dean S, Wang CS, Nam K, et al. Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren’s syndrome mouse model[J]. Rheumatology, 2019, 58(7): 1285-1292.
[31]	Raizada MK, Sable DM. Clinical assessment of efficacy of Omega 3 in oralsubmucous fibrosis patients-A randomized controlled trial[J]. Asian Pac J Cancer Prev, 2022, 23(4): 1185-1192.
[32]	Amézaga J, Ugartemendia G, Larraioz A, et al. Omega 6 polyunsaturated fatty acids in red blood cell membrane are associated with xerostomia and taste loss in patients with breast cancer[J]. Prostaglandins Leukot Essent Fatty Acids, 2021, 173: 102336.
[33]	Gokmenoglu C, Turkmen E, ÖngözDede F, et al. The resolvin D1 levels before and after periodontal therapy in periodontitis patients[J]. Clin Oral Investig, 2022, 26(10): 6379-6385.
[34]	LatorreUriza C, Velosa-Porras J, Roa NS, et al. Periodontal disease, inflammatory cytokines, and PGE₂ in pregnant patients at risk of preterm delivery: A pilot study[J]. Infect Dis Obstet Gynecol, 2018, 2018: 7027683.
[35]	Sette-de-Souza PH, Silva Bezerra WMD, Gomes Dantas MK, et al. Identification of docosahexaenoic and eicosapentaenoic acids multiple targets facing periodontopathogens[J]. Microb Pathog, 2021, 161(Pt A): 105266.
[36]	Ali M, Yang F, Jansen JA, et al. Lipoxin suppresses inflammation via the TLR4/MyD88/NF-κB pathway in periodontal ligament cells[J]. Oral Dis, 2020, 26(2): 429-438.
[37]	Albuquerque-Souza E, Schulte F, Chen T, et al. Maresin-1 and resolvin E1 promote regenerative properties of periodontal ligament stem cells under inflammatory conditions[J]. Front Immunol, 2020, 11: 585530.
[38]	Cai JZ, Liu J, Yan J, et al. Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia[J]. J Periodontal Res, 2022, 57(5): 1034-1042.
[39]	Rakian A, Rakian R, Shay AE, et al. Periodontal stem cells synthesize maresin conjugate in tissue regeneration 3[J]. J Dent Res, 2022, 101(10): 1205-1213.
[40]	Stańdo M, Piatek P, Namiecinska M, et al. Omega-3 polyunsaturated fatty acids EPA and DHA as an adjunct to non-surgical treatment of periodontitis: A randomized clinical trial[J]. Nutrients, 2020, 12(9): 2614.
[41]	Kruse AB, Kowalski CD, Leuthold S, et al. What is the impact of the adjunctive use of omega-3 fatty acids in the treatment of periodontitis? A systematic review and meta-analysis[J]. Lipids Health Dis, 2020, 19(1): 100. doi: 10.1186/s12944-020-01267-x pmid: 32438906
[42]	Dos Santos NC, Araujo CF, Andere NMRB, et al. Omega-3 fatty acids and low-dose aspirin in the treatment of periodontitis and metabolic syndrome: Case report[J]. J Int Acad Periodontol, 2020, 22(4): 223-230. pmid: 32980834
[43]	Paula-Silva FWG, Ribeiro-Santos FR, Petean IBF, et al. Root canal contamination or exposure to lipopolysaccharide differentially modulate prostaglandin E₂ and leukotriene B₄ signaling in apical periodontitis[J]. J Appl Oral Sci, 2020, 28: e20190699.
[44]	Lorencetti-Silva F, Pereira PAT, Meirelles AFG, et al. Prostaglandin E2 induces expression of mineralization genes by undifferentiated dental pulp cells[J]. Braz Dent J, 2019, 30(3): 201-207. doi: S0103-64402019000300201 pmid: 31166389
[45]	da Silva FL, de Campos Chaves Lamarque G, et al. Leukotriene B₄ loaded in microspheres regulate the expression of genes related to odontoblastic differentiation and biomineralization by dental pulp stem cells[J]. BMC Oral Health, 2022, 22(1): 45.
[46]	Gaudin A, Tolar M, Peters OA. Lipoxin A₄ attenuates the inflammatory response in stem cells of the apical papilla via ALX/FPR2[J]. Sci Rep, 2018, 8(1): 8921. doi: 10.1038/s41598-018-27194-7 pmid: 29892010
[47]	Chen J, Xu HX, Xia K, et al. Resolvin E1 accelerates pulp repair by regulating inflammation and stimulating dentin regeneration in dental pulp stem cells[J]. Stem Cell Res Ther, 2021, 12(1): 75. doi: 10.1186/s13287-021-02141-y pmid: 33482900
[48]	Liu XC, Wang CM, Pang LP, et al. Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-κB activation through upregulating sirtuin 7 in dental pulp fibroblasts[J]. Cell Prolif, 2022, 55(5): e13227.
[49]	Chen Q, Wang J, Wang J, et al. Erythrocyte ω-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: A case-control study[J]. Nutr Diabetes, 2020, 10(1): 35. doi: 10.1038/s41387-020-00140-1 pmid: 32989214
[50]	Lee HC, Liang A, Lin YH, et al. Low dietary n-6/n-3 polyunsaturated fatty acid ratio prevents induced oral carcinoma in a hamster pouch model[J]. Prostaglandins Leukot Essent Fatty Acids, 2018, 136: 67-75.
[51]	Ye Y, Scheff NN, Bernabé D, et al. Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma[J]. Neuropharmacology, 2018, 139: 182-193. doi: S0028-3908(18)30377-0 pmid: 30009833
[52]	Sanders AE, Weatherspoon ED, Ehrmann BM, et al. Circulating Omega-6 and Omega-3 polyunsaturated fatty acids in painful temporomandibular disorder and low back pain[J]. J Pain, 2022, 23(10): 1724-1736.
[53]	Sanders AE, Weatherspoon ED, Ehrmann BM, et al. Ratio of Omega-6/Omega-3 polyunsaturated fatty acids associated with somatic and depressive symptoms in people with painful temporomandibular disorder and irritable bowel syndrome[J]. J Pain, 2022, 23(10): 1737-1748.
[54]	Barbin T, Groppo FC, Toledo FC, et al. The effect of omega-3 in temporomandibular joint synovial tissues of rats with induced arthritis: Pilot study[J]. Int J Oral Maxillofac Surg, 2020, 49(10): 1319-1325.

Research progress of the role and application of polyunsaturated fatty acid metabolites in oral diseases

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