抗菌再矿化材料在龋病防治中的研究进展

doi:10.13591/j.cnki.kqyx.2026.05.010

Abstract

Abstract:

Dental caries，as a globally prevalent oral disease，its prevention and treatment critically depends on effectively inhibiting the formation of cariogenic bacterial biofilms and promoting the remineralization of demineralized dental hard tissues. Antibacterial-remineralizing materials，combining the dual functions of combating pathogenic microorganisms and repairing dental hard tissues，have become a current research hotspot. This article systematically reviews the latest research progress of antibacterial-remineralizing materials for the prevention and treatment of dental caries. It focuses on discussing the research status and existing challenges of four material systems： inorganic composite systems，organic polymer composite systems，bioactive molecule-based materials，and smart responsive materials，to provide new material strategies for effectively preventing and managing tooth decay.

Key words: dental caries, Streptococcus mutans, antibacterial, remineralization

CLC Number:

R781.1

CHEN Hongwei, LIU Anya, LIANG Jiaxin, YUAN Yifang, ZHOU Zichao, JIANG Wenkai, WANG Shengchao. Advances in antibacterial-remineralizing materials for dental caries management[J]. Stomatology, 2026, 46(5): 380-387.

References 60

[1]	Van Chuyen N, Van Du V, Van Ba N, et al. The prevalence of dental caries and associated factors among secondary school children in rural highland Vietnam[J]. BMC Oral Health, 2021, 21(1): 349.
[2]	Sangavi R, Malligarjunan N, Pandian SK, et al. Marine-derived Cyclo(l-Leucyl-l-Prolyl)targets d-Alanylation of lipoteichoic acid to combat Streptococcus mutans UA159 mediated dental cariogenesis[J]. Mol Oral Microbiol, 2025, 40(5): 202-222.
[3]	Zhou Y, Huang F, Lin HC. Berberine chloride hydrate impairs Streptococcus mutans biofilm formation via inhibiting sortase A activity[J]. NPJ Biofilms Microbiomes, 2025, 11(1): 120.
[4]	Li YX, Liu MD, Xue MY, et al. Engineered biomaterials trigger remineralization and antimicrobial effects for dental caries restoration[J]. Molecules, 2023, 28(17): 6373.
[5]	Shi JY, Qi XK, Ran Y, et al. Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and in situ remineralization properties for dental caries prevention[J]. Bioact Mater, 2025, 47: 212-228.
[6]	李佳晨, 黄雨梦, 李雨蕾, 等. 纳米生物活性玻璃在牙体硬组织再矿化作用中的研究进展[J]. 赣南医学院学报, 2024, 44(3): 302-305.
[7]	张芮, 贡敏, 祁建艳, 等. 精氨酸联合生物活性玻璃对乳牙釉质龋再矿化影响的研究[J]. 口腔医学, 2021, 41(12): 1073-1076.
[8]	Kanar Ö, Tağtekin D, Korkut B, et al. Accuracy of laser fluorescence in assessment of various caries removal techniques: An in vitro validation[J]. BMC Oral Health, 2024, 24(1): 1529.
[9]	Riaz S, Khan MA, Alomar TS, et al. Synthesis and characteriza-tion of bioactive glass co-doped with silver and copper for prevention of white spot lesions[J]. J Non Cryst Solids, 2025, 652: 123398.
[10]	Simila HO, Boccaccini AR. Sol-gel bioactive glass containing biomaterials for restorative dentistry: A review[J]. Dent Mater, 2022, 38(5): 725-747.
[11]	Dorozhkin SV. Synthetic amorphous calcium phosphates(ACPs): Preparation, structure, properties, and biomedical applications[J]. Biomater Sci, 2021, 9(23): 7748-7798.
[12]	金启予, 邓淑丽, 胡济安. 仿生生物分子材料在牙体硬组织再矿化中的应用[J]. 口腔医学, 2020, 40(11): 1037-1040.
[13]	Degli Esposti L, Ionescu AC, Carella F, et al. Antimicrobial activity of remineralizing ion-doped amorphous calcium phosphates for preventive dentistry[J]. Front Mater, 2022, 9: 846130.
[14]	Yang YW, Xu ZX, Guo YQ, et al. Novel core-shell CHX/ACP nanoparticles effectively improve the mechanical, antibacterial and remineralized properties of the dental resin composite[J]. Dent Mater, 2021, 37(4): 636-647.
[15]	Feng Y, Wu D, Knaus J, et al. A bioinspired gelatin-amorphous calcium phosphate coating on titanium implant for bone regeneration[J]. Adv Healthc Mater, 2023, 12(20): e2203411.
[16]	魏佳峰, 刘星星, 贾康乐, 等. 两性离子聚合物的生物应用研究进展[J]. 精细化工, 2024, 41(12): 2580-2589.
[17]	蔡秀吟, 李成才, 朱海霖, 等. 医用材料表面的抗凝血涂层应用进展[J]. 高分子材料科学与工程, 2025, 41(2): 162-170.
[18]	Kim D, Lee MJ, Kim JY, et al. Incorporation of zwitterionic materials into light-curable fluoride varnish for biofilm inhibition and caries prevention[J]. Sci Rep, 2019, 9(1): 19550.
[19]	He JK, Yang JH, Li M, et al. Polyzwitterion manipulates remineralization and antibiofilm functions against dental demineralization[J]. ACS Nano, 2022, 16(2): 3119-3134.
[20]	Radu ER, Pandele AM, Tuncel C, et al. Preparation and characterization of chitosan/LDH composite membranes for drug delivery application[J]. Membranes, 2023, 13(2): 179.
[21]	李华安, 李志扬, 林博涵, 等. 壳聚糖作为核酸递送载体在基因治疗中的研究进展[J]. 中国新药杂志, 2025, 34(7): 713-719.
[22]	陈彦伶, 张立, 张凌琳, 等. 壳聚糖及其衍生物在口腔疾病防治中的研究进展[J]. 生物工程学报, 2021, 37(7): 2322-2333.
[23]	He JK, Bao YJ, Li J, et al. Nano complexes of carboxymethyl chitosan/amorphous calcium phosphate reduce oral bacteria adherence and biofilm formation on human enamel surface[J]. J Dent, 2019, 80: 15-22.
[24]	Ren Q, Ding LJ, Li ZC, et al. Chitosan hydrogel containing amelogenin-derived peptide: Inhibition of cariogenic bacteria and promotion of remineralization of initial caries lesions[J]. Arch Oral Biol, 2019, 100: 42-48.
[25]	Cakici F, Cakici EB. Antimicrobial efficacy of chitosan versus sodium hypochlorite: A systematic review and meta-analysis[J]. Oral Dis, 2024, 30(8): 5445-5460.
[26]	Pei HR, Bao KY, Han T, et al. Comprehensive insights into microbial-derived antimicrobial peptides(AMPs): Classification, mechanisms, applications, and purification strategies[J]. Crit Rev Biotechnol, 2025, 45(8): 1652-1679.
[27]	Zhang QY, Yan ZB, Meng YM, et al. Antimicrobial peptides: Mechanism of action, activity and clinical potential[J]. Mil Med Res, 2021, 8(1): 48.
[28]	Niu JY, Yin IX, Wu WKK, et al. Antimicrobial peptides for the prevention and treatment of dental caries: A concise review[J]. Arch Oral Biol, 2021, 122: 105022.
[29]	Niu JY, Yin IX, Wu WKK, et al. A novel dual-action antimicrobial peptide for caries management[J]. J Dent, 2021, 111: 103729.
[30]	Wang XQ, Wang YF, Wang K, et al. Bifunctional anticaries peptides with antibacterial and remineralizing effects[J]. Oral Dis, 2019, 25(2): 488-496.
[31]	Zhou L, Li QL, Wong HM. A novel strategy for caries management: Constructing an antibiofouling and mineralizing dual-bioactive tooth surface[J]. ACS Appl Mater Interfaces, 2021, 13(26): 31140-31152.
[32]	袁雪萍, 赵育瑾, 李先平, 等. 鼠李糖乳酪杆菌HM126调节小鼠肠道菌群及代谢物缓解过敏性鼻炎[J]. 食品科学, 2025, 46(14): 157-167.
[33]	Cao MX, Qian ZY, Liang YJ, et al. Layer-by-layer coated probiotics with tannic acid-Ca²⁺ and casein phosphopeptide complexes for caries prevention and enamel remineralization[J]. iScience, 2025, 28(1): 111579.
[34]	Zhu YM, Wang Y, Zhang SY, et al. Association of polymicrobial interactions with dental caries development and prevention[J]. Front Microbiol, 2023, 14: 1162380.
[35]	Elgamily HM, El-Sayed SM, El-Sayed HS, et al. Laboratory evaluation of anti-plaque and remineralization efficacy of sugarless probiotic jelly candy supplemented with natural nano prebiotic additive[J]. Sci Rep, 2023, 13(1): 10977.
[36]	Jafari H, Ghaffari-Bohlouli P, Niknezhad SV, et al. Tannic acid: A versatile polyphenol for design of biomedical hydrogels[J]. J Mater Chem B, 2022, 10(31): 5873-5912.
[37]	Tenenbaum M, Deracinois B, Dugardin C, et al. Identification, production and bioactivity of casein phosphopeptides: A review[J]. Food Res Int, 2022, 157: 111360.
[38]	温柔, 鲁航, 解江琳, 等. 小米糠多酚体外降血脂活性的试验研究[J]. 食品科技, 2024, 49(8): 247-254.
[39]	Li S, Jiang SX, Jia WT, et al. Natural antimicrobials from plants: Recent advances and future prospects[J]. Food Chem, 2024, 432: 137231.
[40]	Dai DN, Wang JR, Xie HS, et al. An epigallocatechin gallate-amorphous calcium phosphate nanocomposite for caries prevention and demineralized enamel restoration[J]. Mater Today Bio, 2023, 21: 100715.
[41]	Yang J, Luo H, He KT, et al. Morphological modulation of copper-doped BiOBr nanomaterial with improved visible light photocatalytic activity for drug-resistant bacteria elimination[J]. Sep Purif Technol, 2025, 368: 132981.
[42]	Jia XY, He KT, Cai L, et al. Coaxially fabricated electrospinning near-infrared light-responsive nanofibrous membranes for combating drug-resistant bacteria[J]. J Hazard Mater, 2025, 492: 138106.
[43]	苏佳峰, 武峰, 李倩, 等. 纳米TiO₂对口腔粘结剂性能的影响研究[J]. 中国胶粘剂, 2024, 33(8): 56-59.
[44]	Wang RX, Jia CH, Zheng NN, et al. Effects of photodynamic therapy on Streptococcus mutans and enamel remineralization of multifunctional TiO₂-HAP composite nanomaterials[J]. Photodiagnosis Photodyn Ther, 2023, 42: 103141.
[45]	Wang RX, Wang YJ, Chen JY, et al. Photocatalytic TiO₂/HAP nanocomposite for antimicrobial treatment, promineralization, and tooth whitening[J]. RSC Adv, 2025, 15(17): 13453-13467.
[46]	Zhang YC, Li CR, Guo AL, et al. Black phosphorus boosts wet-tissue adhesion of composite patches by enhancing water absorption and mechanical properties[J]. Nat Commun, 2024, 15(1): 1618.
[47]	Cheng H, Chen JQ, Wang Y, et al. Sr-doped surfaces with 2D black phosphorus nanosheets for enhanced photothermal antibacterial activity and zirconia implant osseointegration[J]. Regen Biomater, 2025, 12: rbaf033.
[48]	Li RZ, Lu YY, Du WD, et al. Modulating cell stiffness to improve macrophage antibacterial defense: Utilizing spermidine-functionalized black phosphorus nanosheets for periodontitis treatment[J]. J Mater Sci Technol, 2025, 235: 91-109.
[49]	Ran Y, Shi JY, Ding YQ, et al. Black phosphorus nanosheets-loaded mussel-inspired hydrogel with wet adhesion, photothermal antimicrobial, and remineralization capabilities for caries prevention[J]. Adv Sci, 2024, 11(45): e2409155.
[50]	Ren YW, Liu HP, Liu XM, et al. Photoresponsive materials for antibacterial applications[J]. Cell Rep Phys Sci, 2020, 1(11): 100245.
[51]	Wang ZA, Wang YN, Yang CL, et al. Applications of piezoelectric materials in biomedical engineering[J]. Macromol Biosci, 2025, 25(8): e2500033.
[52]	Zeng KC, Lin YF, Liu SR, et al. Applications of piezoelectric biomaterials in dental treatments: A review of recent advancements and future prospects[J]. Mater Today Bio, 2024, 29: 101288.
[53]	Yang TY, Sa RN, Wang FR, et al. Research progress of piezoelectric materials in protecting oral health and treating oral diseases: A mini-review[J]. Front Bioeng Biotechnol, 2024, 12: 1473126.
[54]	Montoya C, Jain A, Londoño JJ, et al. Multifunctional dental composite with piezoelectric nanofillers for combined antibacterial and mineralization effects[J]. ACS Appl Mater Interfaces, 2021, 13(37): 43868-43879.
[55]	Wei YH, Hu X, Shao J, et al. Daily sonic toothbrush triggered biocompatible BaTiO₃/chitosan multiporous coating with enhanced piezocatalysis for intraoral antibacterial activity[J]. Mater Today Commun, 2024, 38: 107715.
[56]	Su HH, An H, Tan SY, et al. PH-dependent reversible self-assembly of β-lactoglobulin-derived reducing peptides[J]. J Agric Food Chem, 2024, 72(16): 9468-9476.
[57]	Li MD, Wan XF, Shan BJ, et al. A pH and GSH dual responsive nanoparticle co-deliver Adriamycin and Olaparib enhanced the therapeutic efficacy on triple negative breast cancer[J]. Mater Des, 2025, 256: 114271.
[58]	He YP, Vasilev K, Zilm P. pH-responsive biomaterials for the treatment of dental caries: A focussed and critical review[J]. Pharmaceutics, 2023, 15(7): 1837.
[59]	Li Q, Liu JB, Liu HJ, et al. Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion[J]. Bioact Mater, 2023, 29: 72-84.
[60]	Xu Y, You Y, Yi LY, et al. Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration[J]. Bioact Mater, 2023, 20: 418-433.

Advances in antibacterial-remineralizing materials for dental caries management

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