抗菌再矿化材料在龋病防治中的研究进展

doi:10.13591/j.cnki.kqyx.2026.05.010

摘要/Abstract

摘要：

龋病作为全球高发的口腔疾病，其防治的关键在于有效抑制致龋菌生物膜的形成并促进脱矿牙体硬组织的再矿化。抗菌再矿化材料因兼具抑制病原微生物与修复牙体硬组织的双重功能，成为当前的研究热点。本文系统综述了抗菌再矿化材料在龋病防治中的最新研究进展，重点探讨了无机材料复合体系、有机高分子材料复合体系、生物活性分子材料及智能响应型材料4类材料体系的研究现状及面临的挑战，以期为龋病的防治提供新的材料策略。

关键词: 龋病, 变异链球菌, 抗菌, 再矿化

Abstract:

Dental caries，as a globally prevalent oral disease，its prevention and treatment critically depends on effectively inhibiting the formation of cariogenic bacterial biofilms and promoting the remineralization of demineralized dental hard tissues. Antibacterial-remineralizing materials，combining the dual functions of combating pathogenic microorganisms and repairing dental hard tissues，have become a current research hotspot. This article systematically reviews the latest research progress of antibacterial-remineralizing materials for the prevention and treatment of dental caries. It focuses on discussing the research status and existing challenges of four material systems： inorganic composite systems，organic polymer composite systems，bioactive molecule-based materials，and smart responsive materials，to provide new material strategies for effectively preventing and managing tooth decay.

Key words: dental caries, Streptococcus mutans, antibacterial, remineralization

中图分类号:

R781.1

陈鸿炜, 刘安雅, 梁嘉鑫, 袁一方, 周子超, 蒋文凯, 王胜朝. 抗菌再矿化材料在龋病防治中的研究进展[J]. 口腔医学, 2026, 46(5): 380-387.

CHEN Hongwei, LIU Anya, LIANG Jiaxin, YUAN Yifang, ZHOU Zichao, JIANG Wenkai, WANG Shengchao. Advances in antibacterial-remineralizing materials for dental caries management[J]. Stomatology, 2026, 46(5): 380-387.

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