褪黑素在周围神经损伤修复中的应用

doi:10.13591/j.cnki.kqyx.2024.08.011

Abstract

Abstract:

The increasing incidence of peripheral nerve injuries brought on by trauma or tumors is substantially interfering with people's lives due to the causal sensory and motor dysfunctions. Peripheral nerves have some self-repair ability after injury, but they are limited by the degree of injury and the body's condition. The postoperative recovery of nerve function in patients is not satisfactory, which is closely related to the local inflammatory microenvironment after injury. Melatonin, a compound naturally synthesized in the pineal gland, protects peripheral nervous system cells from oxidative inflammation after injury and regulates their behavior and fate.Therefore, it has good application prospect in nerve tissue engineering. In this paper, we review the synthesis, metabolic processes underlying melatonin, mechanism of action as well as the current status of its application in peripheral nerve regeneration as well as potential application for oral diseases. In this way, it further provides a new idea for the clinical treatment of peripheral nerve injury.

Key words: peripheral nerve injury, melatonin, anti-inflammatory, cell behavior and fate regulation, mechanism

CLC Number:

R782.4

LIN Lining, SUN Mouyuan, WANG Huiming. Application of melatonin in peripheral nerve injury repair[J]. Stomatology, 2024, 44(8): 617-623.

Figures/Tables 1

References 78

[1]	Hewson DW, Bedforth NM, Hardman JG. Peripheral nerve injury arising in anaesthesia practice[J]. Anaesthesia, 2018, 73(Suppl 1): 51-60.
[2]	Renton T. Prevention of iatrogenic inferior alveolar nerve injuries in relation to dental procedures[J]. Dent Update, 2010, 37(6): 350-352, 354-356, 358-360.
[3]	Liu ZG, Wang B, Yang LH. A modified method for minimizing damage to the marginal mandibular branch(MMB)during partial superficial parotidectomy(PSP): A retrospective study[J]. J Craniomaxillofac Surg, 2022, 50(8): 637-642.
[4]	Troux C, Trandafir C, Zugun C, et al. Great auricular nerve conservation and parotidectomy for tumor[J]. Eur Ann Otorhinolaryngol Head Neck Dis, 2023, 140(3): 131-134.
[5]	Wojtkiewicz DM, Saunders J, Domeshek L, et al. Social impact of peripheral nerve injuries[J]. Hand, 2015, 10(2): 161-167. doi: 10.1007/s11552-014-9692-0 pmid: 26034424
[6]	Yildiran H, Macit MS, Özata Uyar G. New approach to peripheral nerve injury: Nutritional therapy[J]. Nutr Neurosci, 2020, 23(10): 744-755. doi: 10.1080/1028415X.2018.1554322 pmid: 30526417
[7]	Isaacs J, Browne T. Overcoming short gaps in peripheral nerve repair: Conduits and human acellular nerve allograft[J]. Hand, 2014, 9(2): 131-137. doi: 10.1007/s11552-014-9601-6 pmid: 24839412
[8]	Matsuyama T, MacKay M, Midha R. Peripheral nerve repair and grafting techniques: A review[J]. Neurol Med Chir, 2000, 40(4): 187-199.
[9]	Martin SL, Reid AJ, Verkhratsky A, et al. Gene expression changes in dorsal root Ganglia following peripheral nerve injury: Roles in inflammation, cell death and nociception[J]. Neural Regen Res, 2019, 14(6): 939-947. doi: 10.4103/1673-5374.250566 pmid: 30761997
[10]	Kalinski AL, Yoon C, Huffman LD, et al. Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement[J]. ELife, 2020, 9: e60223.
[11]	Zhou HY, Yan Y, Ee XP, et al. Imaging of radicals following injury or acute stress in peripheral nerves with activatable fluorescent probes[J]. Free Radic Biol Med, 2016, 101: 85-92.
[12]	Li XL, Guan YJ, Li CC, et al. Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury[J]. Stem Cell Res Ther, 2022, 13(1): 18.
[13]	Mauriz JL, Collado PS, Veneroso C, et al. A review of the molecular aspects of melatonin's anti-inflammatory actions: Recent insights and new perspectives[J]. J Pineal Res, 2013, 54(1): 1-14. doi: 10.1111/j.1600-079X.2012.01014.x pmid: 22725668
[14]	Tan DX, Manchester LC, Esteban-Zubero E, et al. Melatonin as a potent and inducible endogenous antioxidant: Synthesis and metabolism[J]. Molecules, 2015, 20(10): 18886-18906.
[15]	Szewczuk LM, Tarrant MK, Sample V, et al. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis[J]. Biochemistry, 2008, 47(39): 10407-10419.
[16]	Reiter RJ. Melatonin: The chemical expression of darkness[J]. Mol Cell Endocrinol, 1991, 79(1/2/3): C153-C158.
[17]	Reiter RJ, Mayo JC, Tan DX, et al. Melatonin as an antioxidant: Under promises but over delivers[J]. J Pineal Res, 2016, 61(3): 253-278. doi: 10.1111/jpi.12360 pmid: 27500468
[18]	Venegas C, García JA, Escames G, et al. Extrapineal melatonin: Analysis of its subcellular distribution and daily fluctuations[J]. J Pineal Res, 2012, 52(2): 217-227. doi: 10.1111/j.1600-079X.2011.00931.x pmid: 21884551
[19]	Ma XC, Idle JR, Krausz KW, et al. Metabolism of melatonin by human cytochromes p450[J]. Drug Metab Dispos, 2005, 33(4): 489-494. pmid: 15616152
[20]	Noda Y, Mori A, Liburdy R, et al. Melatonin and its precursors scavenge nitric oxide[J]. J Pineal Res, 1999, 27(3): 159-163. pmid: 10535765
[21]	Galano A, Reiter RJ. Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection[J]. J Pineal Res, 2018, 65(1): e12514.
[22]	García JJ, López-Pingarrón L, Almeida-Souza P, et al. Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: A review[J]. J Pineal Res, 2014, 56(3): 225-237. doi: 10.1111/jpi.12128 pmid: 24571249
[23]	Pandi-Perumal SR, Trakht I, Srinivasan V, et al. Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways[J]. Prog Neurobiol, 2008, 85(3): 335-353. doi: 10.1016/j.pneurobio.2008.04.001 pmid: 18571301
[24]	Hardeland R. Melatonin: Signaling mechanisms of a pleiotropic agent[J]. Bio Factors, 2009, 35(2): 183-192.
[25]	Jessen KR, Arthur-Farraj P. Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves[J]. Glia, 2019, 67(3): 421-437. doi: 10.1002/glia.23532 pmid: 30632639
[26]	Gomez-Sanchez JA, Carty L, Iruarrizaga-Lejarreta M, et al. Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves[J]. J Cell Biol, 2015, 210(1): 153-168. doi: 10.1083/jcb.201503019 pmid: 26150392
[27]	Chen PW, Piao XH, Bonaldo P. Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury[J]. Acta Neuropathol, 2015, 130(5): 605-618. doi: 10.1007/s00401-015-1482-4 pmid: 26419777
[28]	Mokarram N, Merchant A, Mukhatyar V, et al. Effect of modulating macrophage phenotype on peripheral nerve repair[J]. Biomaterials, 2012, 33(34): 8793-8801. doi: 10.1016/j.biomaterials.2012.08.050 pmid: 22979988
[29]	Zhang Q, Chen JL, Feng Y, et al. Electroactive scaffolds of biodegradable polyurethane/polydopamine-functionalized graphene oxide regulating the inflammatory response and revitalizing the axonal growth cone for peripheral nerve regeneration[J]. J Mater Chem B, 2023, 11(27): 6308-6318. doi: 10.1039/d3tb00837a pmid: 37326438
[30]	Cattin AL, Burden JJ, Van Emmenis L, et al. Macrophage-induced blood vessels guide schwann cell-mediated regeneration of peripheral nerves[J]. Cell, 2015, 162(5): 1127-1139.
[31]	Chang HM, Liu CH, Hsu WM, et al. Proliferative effects of melatonin on Schwann cells: Implication for nerve regeneration following peripheral nerve injury[J]. J Pineal Res, 2014, 56(3): 322-332.
[32]	Tiong YL, Ng KY, Koh RY, et al. Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell-derived neurotrophic factor expression[J]. Exp Ther Med, 2020, 20(5): 16.
[33]	Govindasamy N, Chung Chok K, Ying Ng P, et al. Melatonin induced schwann cell proliferation and dedifferentiation through NF-κB, FAK-dependent but src-independent pathways[J]. Rep Biochem Mol Biol, 2022, 11(1): 63-73.
[34]	Kano F, Matsubara K, Ueda M, et al. Secreted ectodomain of sialic acid-binding ig-like lectin-9 and monocyte chemoattractant protein-1 synergistically regenerate transected rat peripheral nerves by altering macrophage polarity[J]. Stem Cells, 2017, 35(3): 641-653. doi: 10.1002/stem.2534 pmid: 27862629
[35]	Xia YY, Chen SY, Zeng SJ, et al. Melatonin in macrophage biology: Current understanding and future perspectives[J]. J Pineal Res, 2019, 66(2): e12547.
[36]	Stazi M, Negro S, Megighian A, et al. Melatonin promotes regeneration of injured motor axons via MT₁ receptors[J]. J Pineal Res, 2021, 70(1): e12695.
[37]	Liu CH, Chang HM, Yang YS, et al. Melatonin promotes nerve regeneration following end-to-side neurorrhaphy by accelerating cytoskeletal remodeling via the melatonin receptor-dependent pathway[J]. Neuroscience, 2020, 429: 282-292.
[38]	Özkan Y, Turgut M, Turan Y, et al. Comparison of the effects of electroacupuncture and melatonin on nerve regeneration in experimentally nerve-damaged rats[J]. J Acupunct Meridian Stud, 2021, 14(5): 176-182. doi: 10.51507/j.jams.2021.14.5.176 pmid: 35770586
[39]	Li XG, Fu J, Zhou HY, et al. The effects of melatonin in the treatment of acute brachial plexus compression injury in rats[J]. Front Neurol, 2023, 14: 1111101.
[40]	Tuna Edizer D, Dönmez Z, Gül M, et al. Effects of melatonin and dexamethasone on facial nerve neurorrhaphy[J]. J Int Adv Otol, 2019, 15(1): 43-50. doi: 10.5152/iao.2018.3273 pmid: 30541731
[41]	Sayan HL, Ozacmak VH, Ozen OA, et al. Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve[J]. J Pineal Res, 2004, 37(3): 143-148. pmid: 15357657
[42]	Shabeeb D, Musa A, Keshavarz M, et al. Melatonin ameliorates radiation-induced sciatic nerve injury[J]. Lett Drug Des Discov, 2019, 17: 21-30.
[43]	Cosovic E, Kapic D, Lujinovic A, et al. Time-dependent proregenerative effects of exogenous melatonin on the transected sciatic nerve[J]. Int J Morphol, 2023, 41(1): 188-194.
[44]	Negro S, Stazi M, Rigoni M, et al. Neurotransmission recovery by melatonin measured by CMAP[J]. Methods Mol Biol, 2022: 413-423.
[45]	Zencirci SG, Bilgin MD, Yaraneri H. Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury[J]. J Neurosci Methods, 2010, 191(2): 277-282.
[46]	Yazar U, Çakır E, Boz C, et al. Electrophysiological, functional and histopathological assessments of high dose melatonin on regeneration after blunt sciatic nerve injury[J]. J Clin Neurosci, 2020, 72: 370-377. doi: S0967-5868(19)31841-7 pmid: 31952974
[47]	Kaya Y, Sarıkcıoğlu L, Aslan M, et al. Comparison of the beneficial effect of melatonin on recovery after cut and crush sciatic nerve injury: A combined study using functional, electrophysiological, biochemical, and electron microscopic analyses[J]. Childs Nerv Syst, 2013, 29(3): 389-401.
[48]	Turgut M, Oktem G, Uysal A, et al. Immunohistochemical profile of transforming growth factor-beta1 and basic fibroblast growth factor in sciatic nerve anastomosis following pinealectomy and exogenous melatonin administration in rats[J]. J Clin Neurosci, 2006, 13(7): 753-758. pmid: 16831553
[49]	Shokouhi G, Tubbs RS, Shoja MM, et al. Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury[J]. Childs Nerv Syst, 2008, 24(1): 111-117.
[50]	Rogério F, de Souza Queiroz L, Teixeira SA, et al. Neuroprotective action of melatonin on neonatal rat motoneurons after sciatic nerve transection[J]. Brain Res, 2002, 926(1/2): 33-41.
[51]	Atik B, Erkutlu I, Tercan M, et al. The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats[J]. J Surg Res, 2011, 166(2): 330-336. doi: 10.1016/j.jss.2009.06.002 pmid: 20006352
[52]	Händel MN, Andersen HK, Ussing A, et al. The short-term and long-term adverse effects of melatonin treatment in children and adolescents: A systematic review and GRADE assessment[J]. E Clinical Medicine, 2023, 61: 102083.
[53]	Foley HM, Steel AE. Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence[J]. Complement Ther Med, 2019, 42: 65-81. doi: S0965-2299(18)30937-3 pmid: 30670284
[54]	Andersen LP, Gögenur I, Rosenberg J, et al. Pharmacokinetics of melatonin: The missing link in clinical efficacy?[J]. Clin Pharmacokinet, 2016, 55(9): 1027-1030. doi: 10.1007/s40262-016-0386-3 pmid: 27000757
[55]	Onger ME, Kaplan S, Deniz ÖG, et al. Possible promoting effects of melatonin, leptin and alcar on regeneration of the sciatic nerve[J]. J Chem Neuroanat, 2017, 81: 34-41. doi: S0891-0618(16)30152-1 pmid: 28163216
[56]	Kaplan S, Pişkin A, Ayyildiz M, et al. The effect of melatonin and platelet gel on sciatic nerve repair: An electrophysiological and stereological study[J]. Microsurgery, 2011, 31(4): 306-313. doi: 10.1002/micr.20876 pmid: 21520268
[57]	Chen TK, Jiang HM, Li X, et al. Proliferation and differentiation study of melatonin functionalized polycaprolactone/gelatin electrospun fibrous scaffolds for nerve tissue engineering[J]. Int J Biol Macromol, 2022, 197: 103-110.
[58]	Qian Y, Han QX, Zhao XT, et al. 3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration[J]. J Pineal Res, 2018, 65(4): e12516.
[59]	Wang YH, Pan J, Wang DR, et al. The use of stem cells in neural regeneration: A review of current opinion[J]. Curr Stem Cell Res Ther, 2018, 13(7): 608-617.
[60]	Luo LH, Gan L, Liu YM, et al. Construction of nerve guide conduits from cellulose/soy protein composite membranes combined with Schwann cells and pyrroloquinoline quinone for the repair of peripheral nerve defect[J]. Biochem Biophys Res Commun, 2015, 457(4): 507-513.
[61]	Salehi M, Naseri-Nosar M, Ebrahimi-Barough S, et al. Polyurethane/gelatin nanofibrils neural guidance conduit containing platelet-rich plasma and melatonin for transplantation of schwann cells[J]. Cell Mol Neurobiol, 2018, 38(3): 703-713. doi: 10.1007/s10571-017-0535-8 pmid: 28823058
[62]	Jiang LF, Jones S, Jia XF. Stem cell transplantation for peripheral nerve regeneration: Current options and opportunities[J]. Int J Mol Sci, 2017, 18(1): 94.
[63]	Zhang ZQ, Zhang MY, Zhang ZX, et al. ADSCs combined with melatonin promote peripheral nerve regeneration through autophagy[J]. Int J Endocrinol, 2022, 2022: 5861553.
[64]	Zhang JC, Ge HG, Li J, et al. Effective regeneration of rat sciatic nerve using nanofibrous scaffolds containing rat ADSCs with controlled release of rhNGF and melatonin molecules for the treatment of peripheral injury model[J]. Regen Ther, 2023, 24: 180-189. doi: 10.1016/j.reth.2023.06.009 pmid: 37427370
[65]	Chen X, Ge XM, Qian Y, et al. Electrospinning multilayered scaffolds loaded with melatonin and Fe₃O₄ magnetic nanoparticles for peripheral nerve regeneration[J]. Adv Funct Materials, 2020, 30(38): 2004537.
[66]	Jiang HQ, Wang X, Li X, et al. A multifunctional ATP-generating system by reduced graphene oxide-based scaffold repairs neuronal injury by improving mitochondrial function and restoring bioelectricity conduction[J]. Mater Today Bio, 2022, 13: 100211.
[67]	Condie D, Tolkachjov SN. Facial nerve injury and repair: A practical review for cutaneous surgery[J]. Dermatol Surg, 2019, 45(3): 340-357. doi: 10.1097/DSS.0000000000001773 pmid: 30640780
[68]	Gordin E, Lee TS, Ducic Y, et al. Facial nerve trauma: Evaluation and considerations in management[J]. Craniomaxillofac Trauma Reconstr, 2015, 8(1): 1-13. doi: 10.1055/s-0034-1372522 pmid: 25709748
[69]	Kaleem A, Amailuk P, Hatoum H, et al. The trigeminal nerve injury[J]. Oral Maxillofac Surg Clin North Am, 2020, 32(4): 675-687.
[70]	Le Donne M, Jouan R, Bourlet J, et al. Inferior alveolar nerve allogenic repair following mandibulectomy: A systematic review[J]. J Stomatol Oral Maxillofac Surg, 2022, 123(2): 233-238.
[71]	Miranda-Riestra A, Estrada-Reyes R, Torres-Sanchez ED, et al. Melatonin: A neurotrophic factor?[J]. Molecules, 2022, 27(22): 7742.
[72]	Zolfagharzadeh V, Ai J, Soltani H, et al. Sustain release of loaded insulin within biomimetic hydrogel microsphere for sciatic tissue engineering in vivo[J]. Int J Biol Macromol, 2023, 225: 687-700.
[73]	Chuffa LGA, Seiva FRF, Novais AA, et al. Melatonin-loaded nanocarriers: New horizons for therapeutic applications[J]. Molecules, 2021, 26(12): 3562.
[74]	Solomevich SO, Oranges CM, Kalbermatten DF, et al. Natural polysaccharides and their derivatives as potential medical materials and drug delivery systems for the treatment of peripheral nerve injuries[J]. Carbohydr Polym, 2023, 315: 120934.
[75]	Kantrong N, Jit-Armart P, Arayatrakoollikit U. Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses[J]. BMC Oral Health, 2020, 20(1): 91.
[76]	Vaseenon S, Chattipakorn N, Chattipakorn SC. Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies[J]. Arch Oral Biol, 2021, 123: 105037.
[77]	Yi HX, Lu WX, Liu F, et al. ROS-responsive liposomes with NIR light-triggered doxorubicin release for combinatorial therapy of breast cancer[J]. J Nanobiotechnology, 2021, 19(1): 134.
[78]	Ding HT, Tan P, Fu SQ, et al. Preparation and application of pH-responsive drug delivery systems[J]. J Control Release, 2022, 348: 206-238.

Application of melatonin in peripheral nerve injury repair

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 1

References 78

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	JIANG Zhenze, ZOU Mingyuan, GONG Guoliang, LIN Xinping. The effect of different conditions of the second molar on maxillary molar distalization using Modified C Palatal Plate——A 3-dimensional finite analysis [J]. Stomatology, 2023, 43(9): 808-813.
[2]	CHEN Nuo,WEI Yan. Progress in the treatment materials of dentin hypersensitivity [J]. Stomatology, 2023, 43(5): 385-392.
[3]	SUN Yuezhang,WANG Qi. Morphological and immune characteristics of periodontal tissues under hyperglycemia [J]. Stomatology, 2023, 43(2): 153-158.
[4]	CHEN Jingru,LI Fengdan,JIANG Yinhua. Progress of research on the mechanism of photobiomodulation therapy for radiation-induced oral mucositis [J]. Stomatology, 2023, 43(12): 1134-1139.
[5]	LI Fengdan, CHEN Jingru, JIANG Yinhua. Research progress of the relationship between periodontitis and diabetic retinopathy [J]. Stomatology, 2023, 43(10): 939-944.
[6]	ZHANG Xiaochen, SUN Weifu, FANG Shishu, QIN Wen, JIN Zuolin. Research progress of N⁶-methyladenosine in regulating osteogenic differentiation [J]. Stomatology, 2022, 42(7): 655-658.
[7]	DONG Junchi, ZHENG Huiling, WEI Yuwen, MA Qian. Antibacterial mechanism and influencing factors of bioactive glasses [J]. Stomatology, 2022, 42(6): 551-556.
[8]	ZHANG Xudong, YANG Xuelian, LIU Xiaqing, MA Yufeng. Advances in research on the application of Er:YAG laser in oral hard tissues [J]. Stomatology, 2022, 42(4): 381-384.
[9]	ZHANG Cheng, LU Di, LIU Zongxiang, WANG Penglai. Advances of research on melatonin in oral implantation therapy [J]. Stomatology, 2022, 42(2): 184-187.
[10]	DAI Jiayun, WANG Shujing, LIN Junyan, TIAN Yu, PAN Yongchu, LI Dandan. Advances in low-level laser therapy for the acceleration of orthodontic tooth movement [J]. Stomatology, 2022, 42(12): 1123-1128.
[11]	BAI Xue, GAO Jinhua, REN Xiuyun. Research progress of the relationship between periodontitis and adverse pregnancy outcomes [J]. Stomatology, 2022, 42(10): 932-937.
[12]	. Antibacterial effect of Radix Paeoniae Rubra and its mechanism of chronic periodontitis prevention and treatment [J]. , 2021, 41(5): 391-397.
[13]	. Study on oxidative stress antibacterial mechanism of rare earth nanocomposites Ce/Ag/ZnO against saccharomyces albicans [J]. , 2021, 41(10): 878-882.
[14]	. Estrogen combined with mechanical tension to regulate osteogenic differentiation of human periodontal ligament fibroblasts and its mechanism [J]. , 2021, 41(1): 6-11.
[15]	. Effect of Citrus reticulate on the growth of main cariogenic bacteria and its pharmacological analysis of its anti-caries mechanism [J]. , 2020, 40(2): 101-107.