牙髓再生支架材料的研究进展

doi:10.13591/j.cnki.kqyx.2025.03.011

Abstract

Abstract:

Pulp regeneration is currently a hot topic in pulp disease research. With the development of regenerative medicine, pulp regeneration is transitioning from basic research to clinical applications, and stable results have been observed in some cases. However, achieving higher success rates and restoring pulp function remains a challenge in the field of pulp disease. Stem cells, growth factors, and scaffold materials are fundamental elements of tissue engineering. In recent years, dental pulp regeneration related scaffolds have received widespread attention, and new progress has been made in natural, human, and artificially synthesized scaffold materials. This article reviews the scaffold materials for pulp regeneration, aiming to provide reference for the selection of scaffold materials for dental pulp regeneration.

Key words: dental pulp regeneration, regenerative endodontic procedures, stem cells, scaffolds

CLC Number:

R781.4

LIU Yuan, YAN Yanhong, JIANG Beizhan. Research progress of scaffold materials for dental pulp regeneration[J]. Stomatology, 2025, 45(3): 218-222.

Figures/Tables 2

Tab.1

Tab.2

References 49

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参考文献	APC	结果
Narang等^[14]	PRF和PRP	临床研究表明,PRF加速牙髓坏死的未成熟恒牙牙根生长,促进作用优于PRP和血凝块
Zhou等^[15]	PRF	PRF联合血凝块可促进比格犬根尖周愈合,促进牙根发育
Nageh等^[16]	PRF	PRF用于REPs,有助于恢复牙齿感觉
Ray等^[17]	PRF	病例报告证明PRF促进REPs的临床效果
Hong等^[18]	CGF和PRF	CGF和PRF均能促进SCAP的增殖、迁移和分化
Xu等^[19]	CGF	在体内外研究中,CGF以剂量依赖的方式促进暴露于LPS的DPSCs的增殖、迁移和分化,并且显示出抗炎作用
Jin等^[20]	CGF	CGF以剂量依赖的方式促进DPSCs的增殖,但高浓度的CGF抑制DPSCs的内皮细胞向分化和成牙本质细胞向分化

参考文献	种类	修饰方法	负载细胞	结果
Terranova等^[43]	PLA和PCL	单宁酸微粒修饰	DPSCs	单宁酸微粒修饰的薄膜支架模拟了ECM,维持细胞活性。将薄膜卷曲为锥形结构促进了细胞迁移。
Soares等^[44]	PLA	将辛伐他汀和纳米纤维偶联支架	牙髓细胞	支架材料减轻了局部炎症,诱导DPSCs产生血管化的牙髓组织。
Chen等^[45]	PLGA	明胶改性支架	牙囊干细胞	通过电纺排列的PLGA/明胶膜片促进了牙囊干细胞的分化,产生牙髓牙本质复合体样结构。
Galler等^[46]	比较PEG、SAP、纤维蛋白和胶原		DPSCs	与PEG和SAP支架相比,天然材料,尤其是纤维蛋白,在细胞活力和牙髓组织形成方面更具优势。
Demarco等^[47]	PLA	模拟牙本质的多孔结构	DPSCs	模拟牙本质的形态可以影响DPSCs的行为,并诱导细胞分化产生牙髓组织。
Itoh等^[48]	聚(N-异丙基丙烯酰胺)	热响应的水凝胶支架	DPSCs	热响应水凝胶在体内实验形成血管化的牙髓组织。

Research progress of scaffold materials for dental pulp regeneration

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