生物膜在种植体表面的形成及其对种植稳态的影响

doi:10.13591/j.cnki.kqyx.2025.08.013

摘要/Abstract

摘要：

种植体周围黏膜炎和种植体周围炎是导致种植义齿失败的主要危险因素之一,菌斑生物膜是这两种种植体周围疾病的始动因素。本文概述了种植体表面菌斑生物膜的形成过程、形成的影响因素及其对种植稳态的影响,为菌斑生物膜的清除及提高种植体的成功率提供参考。

Abstract:

Peri-implant mucositis and peri-implantitis are among the primary risk factors for the failure of dental implants, with plaque biofilm being the initiating factor for these peri-implant diseases. This paper reviews the formation process of plaque biofilm on implant surfaces, the influencing factors of its formation, and its impact on implant homeostasis. It provides insights for the removal of plaque biofilm and the improvement of implant success rates.

Key words: biofilm, implant, implant homeostasis

中图分类号:

R783.4

刘宇涵, 孟维艳. 生物膜在种植体表面的形成及其对种植稳态的影响[J]. 口腔医学, 2025, 45(8): 637-640.

LIU Yuhan, MENG Weiyan. Formation of biofilm on implant surfaces and its impact on implant homeostasis[J]. Stomatology, 2025, 45(8): 637-640.

参考文献 38

[1]	Howe MS, Keys W, Richards D. Long-term(10-year)dental implant survival: A systematic review and sensitivity meta-analysis[J]. J Dent, 2019, 84: 9-21.
[2]	Wada M, Mameno T, Otsuki M, et al. Prevalence and risk indicators for peri-implant diseases: A literature review[J]. Jpn Dent Sci Rev, 2021, 57: 78-84.
[3]	Berglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions[J]. Clin Periodontol, 2018, 45(Suppl 20):S286-S291.
[4]	Bowen WH, Burne RA, Wu H, et al. Oral biofilms: Pathogens, matrix, and polymicrobial interactions in microenvironments[J]. Trends Microbiol, 2018, 26(3): 229-242. doi: S0966-842X(17)30213-5 pmid: 29097091
[5]	Karygianni L, Ren Z, Koo H, et al. Biofilm matrixome: Extracellular components in structured microbial communities[J]. Trends Microbiol, 2020, 28(8): 668-681. doi: S0966-842X(20)30087-1 pmid: 32663461
[6]	Rosier BT, Marsh PD, Mira A. Resilience of the oral microbiota in health: Mechanisms that prevent dysbiosis[J]. J Dent Res, 2018, 97(4): 371-380. doi: 10.1177/0022034517742139 pmid: 29195050
[7]	Souza JGS, Bertolini MM, Costa RC, et al. Targeting implant-associated infections: Titanium surface loaded with antimicrobial[J]. iScience, 2021, 24(1): 102008.
[8]	Kreve S, Reis ACD. Bacterial adhesion to biomaterials: What regulates this attachment?A review[J]. Jpn Dent Sci Rev, 2021, 57: 85-96.
[9]	Alves CH, Russi KL, Rocha NC, et al. Host-microbiome interactions regarding peri-implantitis and dental implant loss[J]. J Transl Med, 2022, 20(1): 425. doi: 10.1186/s12967-022-03636-9 pmid: 36138430
[10]	Shrivastava D, Natoli V, Srivastava KC, et al. Novel approach to dental biofilm management through guided biofilm therapy(GBT): A review[J]. Microorganisms, 2021, 9(9): 1966.
[11]	Costa RC, Nagay BE, Dini C, et al. The race for the optimal antimicrobial surface: Perspectives and challenges related to plasma electrolytic oxidation coating for titanium-based implants[J]. Adv Colloid Interface Sci, 2023, 311: 102805.
[12]	Siddiqui DA, Fidai AB, Natarajan SG, et al. Succession of oral bacterial colonizers on dental implant materials: An biofilm model[J]. Dent Mater, 2022, 38(2): 384-396.
[13]	Bermejo P, Sánchez MC, Llama-Palacios A, et al. Topographic characterization of multispecies biofilms growing on dental implant surfaces: An model[J]. Clin Oral Implants Res, 2019, 30(3): 229-241.
[14]	Ghimire A, Song J. Anti-periprosthetic infection strategies: From implant surface topographical engineering to smart drug-releasing coatings[J]. ACS Appl Mater Interfaces, 2021, 13(18): 20921-20937.
[15]	Bermejo P, Sánchez MC, Llama-Palacios A, et al. Biofilm formation on dental implants with different surface micro-topography: An study[J]. Clin Oral Implants Res, 2019, 30(8): 725-734.
[16]	Safaei M, Mohammadi H, Beddu S, et al. Surface topography steer soft tissue response and antibacterial function at the transmucosal region of titanium implant[J]. Int J Nanomedicine, 2024, 19: 4835-4856.
[17]	Chopra D, Guo TQ, Jayasree A, et al. Bioinspired, bioactive, and bactericidal: Anodized nanotextured dental implants[J]. Adv Funct Mater, 2024, 34(30): 2314031.
[18]	Gao Q, Feng T, Huang DN, et al. Antibacterial and hydroxyapatite-forming coating for biomedical implants based on polypeptide-functionalized titania nanospikes[J]. Biomater Sci, 2020, 8(1): 278-289.
[19]	Villegas M, Bayat F, Kramer T, et al. Emerging strategies to prevent bacterial infections on titanium-based implants[J]. Small, 2024, 20(46): e2404351.
[20]	Guo LL, Cheng YF, Ren X, et al. Simultaneous deposition of tannic acid and poly(ethylene glycol) to construct the antifouling polymeric coating on Titanium surface[J]. Colloids Surf B Biointerfaces, 2021, 200: 111592.
[21]	Zuo KQ, Wang LL, Wang ZH, et al. Zinc-doping induces evolution of biocompatible strontium-calcium-phosphate conversion coating on titanium to improve antibacterial property[J]. ACS Appl Mater Interfaces, 2022, 14(6): 7690-7705.
[22]	Tardelli JDC, Bagnato VS, Reis ACD. Bacterial adhesion strength on titanium surfaces quantified by atomic force microscopy: A systematic review[J]. Antibiotics(Basel), 2023, 12(6): 994.
[23]	Gittens RA, Scheideler L, Rupp F, et al. A review on the wettability of dental implant surfaces Ⅱ: Biological and clinical aspects[J]. Acta Biomater, 2014, 10(7): 2907-2918.
[24]	Alam F, Balani K. Adhesion force of Staphylococcus aureus on various biomaterial surfaces[J]. J Mech Behav Biomed Mater, 2017, 65: 872-880.
[25]	Chopra D, Jayasree A, Guo TQ, et al. Advancing dental implants: Bioactive and therapeutic modifications of zirconia[J]. Bioact Mater, 2022, 13: 161-178. doi: 10.1016/j.bioactmat.2021.10.010 pmid: 35224299
[26]	Roehling S, Astasov-Frauenhoffer M, Hauser-Gerspach I, et al. biofilm formation on titanium and zirconia implant surfaces[J]. J Periodontol, 2017, 88(3): 298-307. doi: 10.1902/jop.2016.160245 pmid: 27712464
[27]	de Freitas AR, Silva TSO, Ribeiro RF, et al. Oral bacterial colonization on dental implants restored with titanium or zirconia abutments: 6-month follow-up[J]. Clin Oral Investig, 2018, 22(6): 2335-2343.
[28]	Santhosh Kumar S, Hiremath SS, Ramachandran B, et al. Effect of surface finish on wettability and bacterial adhesion of micromachined biomaterials[J]. Biotribology, 2019, 18: 100095.
[29]	Costa RC, Nagay BE, Bertolini M, et al. Fitting pieces into the puzzle: The impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infections[J]. Adv Colloid Interface Sci, 2021, 298: 102551.
[30]	Kheder W, Al Kawas S, Khalaf K, et al. Impact of tribocorrosion and titanium particles release on dental implant complications: A narrative review[J]. Jpn Dent Sci Rev, 2021, 57: 182-189.
[31]	Daubert DM, Weinstein BF. Biofilm as a risk factor in implant treatment[J]. Periodontol 2000, 2019, 81(1): 29-40. doi: 10.1111/prd.12280 pmid: 31407437
[32]	Kotsakis GA, Olmedo DG. Peri-implantitis is not periodontitis: Scientific discoveries shed light on microbiome-biomaterial interactions that may determine disease phenotype[J]. Periodontol 2000, 2021, 86(1): 231-240. doi: 10.1111/prd.12372 pmid: 33690947
[33]	Safioti LM, Kotsakis GA, Pozhitkov AE, et al. Increased levels of dissolved titanium are associated with peri-implantitis: A cross-sectional study[J]. J Periodontol, 2017, 88(5): 436-442.
[34]	Daubert D, Pozhitkov A, McLean J, et al. Titanium as a modifier of the peri-implant microbiome structure[J]. Clin Implant Dent Relat Res, 2018, 20(6): 945-953.
[35]	Ng E, Tay JRH, Mattheos N, et al. A mapping review of the pathogenesis of peri-implantitis: The biofilm-mediated inflammation and bone dysregulation(BIND)hypothesis[J]. Cells, 2024, 13(4): 315.
[36]	Rahnama-Hezavah M, Mertowska P, Mertowski S, et al. How can imbalance in oral microbiota and immune response lead to dental implant problems?[J]. Int J Mol Sci, 2023, 24(24): 17620.
[37]	Wicherska-Pawłowska K, Wróbel T, Rybka J. Toll-like receptorsTLRs, NOD-like receptors(NLRs), and RIG-I-like receptors(RLRs)in innate immunity. TLRs, NLRs, and RLRs ligands as immunotherapeutic agents for hematopoietic diseases[J]. Int J Mol Sci, 2021, 22(24): 13397.
[38]	Guo T, Gulati K, Arora H, et al. Race to invade: Understanding soft tissue integration at the transmucosal region of titanium dental implants[J]. Dent Mater, 2021, 37(5): 816-831. doi: 10.1016/j.dental.2021.02.005 pmid: 33676764