小分子化合物延缓间充质干细胞衰老的研究进展

doi:10.13591/j.cnki.kqyx.2022.03.015

Abstract

Abstract: Cell senescence caused by various factors restricts the application of mesenchymal stem cells (MSCs) in oral tissue regeneration. However, part of small molecule compounds could delay the senescence of MSCs and extend characteristics of stem cells. This article introduces features of senescent MSCs, and summarizes possible therapeutic targets together with mechanisms of hotspot small molecule compounds, so as to supplement certain theoretical basis for promoting the future development of oral regenerative medicine.

Key words: mesenchymal stem cell, small molecule compound, cell senescence, therapeutic target

CLC Number:

R349.53

FENG Xiaomei, HAO Xingyao, WEN Yong. Advance of research on small molecule compounds delaying senescence of mesenchymal stem cells[J]. Stomatology, 2022, 42(3): 266-270.

References

[1] Fitzsimmons REB, Mazurek MS, Soos A, et al. Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering[J]. Stem Cells Int, 2018, 2018:8031718.
[2] HuangXY, Li ZH, Liu AQ, et al. Microenvironment influences odontogenic mesenchymal stem cells mediated dental pulp regeneration[J]. Front Physiol, 2021, 12:656588.
[3] He S, Sharpless NE. Senescence in health and disease[J]. Cell, 2017, 169(6):1000-1011.
[4] Frobel J, Hemeda H, Lenz M,et al. Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells[J]. Stem Cell Reports, 2014, 3(3):414-422.
[5] 吴晓恋, 傅稼耀, 武文婧, 等. 外泌体对老龄小鼠骨髓间充质干细胞衰老影响的初步研究[J]. 口腔颌面外科杂志, 2020, 30(3):137-143.
[6] Zhang YP, Xing YX, Jia LL, et al. An in vitro comparative study of multisource derived human mesenchymal stem cells for bone tissue engineering[J]. Stem Cells Dev, 2018, 27(23):1634-1645.
[7] Pittenger MF, MacKay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284(5411):143-147.
[8] Dominici M,le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement[J]. Cytotherapy, 2006, 8(4):315-317.
[9] Franzke B, Halper B, Hofmann M,et al. The impact of six months strength training, nutritional supplementation or cognitive training on DNA damage in institutionalised elderly[J]. Mutagenesis, 2015, 30(1):147-153.
[10] Liu J, Wang LH, Wang ZG, et al. Roles of telomere biology in cell senescence, replicative and chronological ageing[J]. Cells, 2019, 8(1):E54.
[11] Wiley CD, Velarde MC, Lecot P, et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype[J]. Cell Metab, 2016, 23(2):303-314.
[12] Burova E, Borodkina A, Shatrova A,et al. Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium[J]. Oxid Med Cell Longev, 2013, 2013:474931.
[13] Ma Y, Qi M, An Y,et al. Autophagy controls mesenchymal stem cell properties and senescence during bone aging[J]. Aging Cell, 2018, 17(1):e12709. DOI:10.1111/acel.12709.
[14] Saidova AA, Vorobjev IA. Lineage commitment, signaling pathways, and the cytoskeleton systems in mesenchymal stem cells[J]. Tissue Eng Part B Rev, 2020, 26(1):13-25.
[15] Collado M, Serrano M. The power and the promise of oncogene-induced senescence markers[J]. Nat Rev Cancer, 2006, 6(6):472-476.
[16] Nakagami H. Cellular senescence and senescence-associated T cells as a potential therapeutic target[J]. Geriatr Gerontol Int, 2020, 20(2):97-100.
[17] Calcinotto A, Kohli J, Zagato E,et al. Cellular senescence:Aging, cancer, and injury[J]. Physiol Rev, 2019, 99(2):1047-1078.
[18] Turinetto V, Vitale E, Giachino C. Senescence inhuman mesenchymal stem cells:Functional changes and implications in stem cell-based therapy[J]. Int J Mol Sci, 2016, 17(7):E1164.
[19] Martel J, Ojcius DM, Wu CY, et al. Emerging use of senolytics and senomorphics against aging and chronic diseases[J]. Med Res Rev, 2020, 40(6):2114-2131.
[20] Amaya-Montoya M, Pérez-Londoño A, Guatibonza-García V, et al. Cellular senescence as a therapeutic target for age-related diseases:A review[J]. Adv Ther, 2020, 37(4):1407-1424.
[21] LeeBY, Han JG, Im JS, et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase[J]. Aging Cell, 2006, 5(2):187-195.
[22] Chandra T, Ewels PA, Schoenfelder S, et al. Global reorganiza-tion of the nuclear landscape in senescent cells[J]. Cell Rep, 2015, 10(4):471-483.
[23] Zhang WQ, Li JY, Suzuki K, et al. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging[J]. Science, 2015, 348(6239):1160-1163.
[24] Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease[J]. Cell, 2017, 168(6):960-976.
[25] Liu HL, Huang B, Xue SL, et al. Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs[J]. Stem Cell Res Ther, 2020, 11(1):279.
[26] Zhou T, Yan YR, Zhao CC, et al. Resveratrol improves osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species production via AMPK activation[J]. Redox Rep, 2019, 24(1):62-69.
[27] Yoon DS, Choi Y, Choi SM, et al. Different effects of resveratrol on early and late passage mesenchymal stem cells through β-catenin regulation[J]. Biochem Biophys Res Commun, 2015, 467(4):1026-1032.
[28] Wang XX, Ma SS, Meng N, et al. Resveratrol exerts dosage-dependent effects on the self-renewal and neural differentiation of hUC-MSCs[J]. Mol Cells, 2016, 39(5):418-425.
[29] Yoon DS, Choi Y, Jang Y, et al. SIRT1 directly regulates SOX2 to maintain self-renewal and multipotency in bone marrow-derived mesenchymal stem cells[J]. Stem Cells, 2014, 32(12):3219-3231.
[30] Kornienko JS, Smirnova IS, Pugovkina NA, et al. High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells[J]. Sci Rep, 2019, 9(1):1296.
[31] Liao NS, Shi YJ, Zhang CL, et al. Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion[J]. Stem Cell Res Ther, 2019, 10(1):306.
[32] Zhou L, Chen X, Liu T,et al. Melatonin reverses H₂ O₂ -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway[J]. J Pineal Res, 2015, 59(2):190-205.
[33] Han YS, Kim SM, Lee JH, et al. Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP^C -dependent enhancement of the mitochondrial function[J]. J Pineal Res, 2019, 66(1):e12535. DOI:10.1111/jpi.12535.
[34] Fang J, Yan Y, Teng X,et al. Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF₂ and inhibiting ER stress[J]. Aging (Albany NY), 2018, 10(10):2954-2972.
[35] Yun SP, Han YS, Lee JH, et al. Melatonin rescues mesenchymal stem cells from senescence induced by the uremic toxin p-cresol via inhibiting mTOR-dependent autophagy[J]. Biomol Ther (Seoul), 2018, 26(4):389-398.
[36] Pirmoradi S, Fathi E, Farahzadi R,et al. Curcumin affects adipose tissue-derived mesenchymal stem cell aging through TERT gene expression[J]. Drug Res (Stuttg), 2018, 68(4):213-221.
[37] Mato-Basalo R, Morente-López M, Arntz OJ, et al. Therapeutic potential for regulation of the nuclear factor kappa-B transcription factor p65 to prevent cellular senescence and activation of pro-inflammatory in mesenchymal stem cells[J]. Int J Mol Sci, 2021, 22(7):3367.
[38] Gao B, Lin XS, Jing H, et al. Local delivery of tetramethy-lpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice[J]. Aging Cell, 2018, 17(3):e12741. DOI:10.1111/acel.12741.
[39] Shin JH, Jeon HJ, Park J, et al. Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2[J]. Int J Mol Med, 2016, 38(4):1075-1082.
[40] Geng LL, Liu ZP, Zhang WQ, et al. Chemical screen identifies a geroprotective role of quercetin in premature aging[J]. Protein Cell, 2019, 10(6):417-435.
[41] Kuang YC, Hu B, Feng G, et al. Metformin prevents against oxidative stress-induced senescence in human periodontal ligament cells[J]. Biogerontology, 2020, 21(1):13-27.
[42] Kim H, Yu MR, Lee H, et al. Metformin inhibits chronic kidney disease-induced DNA damage and senescence of mesenchymal stem cells[J]. Aging Cell, 2021, 20(2):e13317. DOI:10.1111/acel.13317.
[43] 苏路路, 管博文, 樊飞跃, 等. 衰老细胞清除剂研究进展[J]. 中国药理学通报, 2019, 35(10):1333-1337.
[44] Hickson LJ, Langhi Prata LGP, Bobart SA, et al. Senolytics decrease senescent cells in humans:Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease[J]. E Bio Medicine, 2019, 47:446-456.
[45] Zhu Y, Tchkonia T, Pirtskhalava T,et al. The Achilles' heel of senescent cells:From transcriptome to senolytic drugs[J]. Aging Cell, 2015, 14(4):644-658.
[46] Grezella C, Fernandez-Rebollo E, Franzen J,et al. Effects of senolytic drugs on human mesenchymal stromal cells[J]. Stem Cell Res Ther, 2018, 9(1):108.
[47] Fuhrmann-Stroissnigg H, LingYY, Zhao J, et al. Identification of HSP90 inhibitors as a novel class of senolytics[J]. Nat Commun, 2017, 8(1):422.

Advance of research on small molecule compounds delaying senescence of mesenchymal stem cells

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[10]	. Effects of microspheres modified with collagen I on the adhesion, proliferation and osteogenesis of BMSCs [J]. , 2020, 40(4): 299-303.
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