Copine7蛋白在牙、牙周组织发育与再生中的作用

doi:10.13591/j.cnki.kqyx.2023.07.012

Abstract

Abstract:

Copine 7(CPNE7), a calcium phospholipid-binding protein found in preameloblast-conditioned medium(PACM), is initially expressed and secreted by dental epithelial cells. CPNE7 plays an important role in the differentiation of dental mesenchymal cells to odontoblasts. Recently, accumulating evidence has demonstrated that CPNE7 can induce the tertiary dentin formation and reduce the permeability of dentin by promoting mineral deposition in dentinal tubules, which allows CPNE7 to be applied in dentin repair. Besides, CPNE7 has shown positive effects on cementogenesis, but has no obvious relationship to the formation of periodontal ligament(PDL). In this study, we summarized research progress of the roles and mechanisms of CPNE7 in the development of dentin and periodontium, offering new approaches to treating related diseases.

Key words: Copine 7, dentin, periodontium, tissue regeneration, CPNE7 derivative

CLC Number:

R781.4

YANG Yue, ZHAO Mingyu, XIE Xudong, WANG Jun. Roles of Copine 7 in the development and regeneration of teeth and periodontium[J]. Stomatology, 2023, 43(7): 647-651.

Figures/Tables 2

References 36

[1]	Savino M, D'Apolito M, Centra M, et al. Characterization of copine Ⅶ, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3[J]. Genomics, 1999, 61(2):219-226. pmid: 10534407
[2]	Lee JH, Lee DS, Choung HW, et al. Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors[J]. Biomaterials, 2011, 32(36):9696-9706. doi: 10.1016/j.biomaterials.2011.09.007
[3]	Choung HW, Lee DS, Lee JH, et al. Tertiary dentin formation after indirect pulp capping using protein CPNE7[J]. J Dent Res, 2016, 95(8):906-912. doi: 10.1177/0022034516639919 pmid: 27013639
[4]	Yu SJ, Lee YS, Choung HW, et al. Effect of preameloblast-conditioned medium and CPNE7 on root surfaces in dogs: A histologic and histomorphometric evaluation[J]. J Mol Histol, 2018, 49(3):265-276.
[5]	刘紫奇, 葛少华. CPNE7在口腔组织再生中的相关研究进展[J]. 口腔医学, 2020, 40(11):1050-1053.
[6]	Singh V, Ram M, Kumar R, et al. Phosphorylation: Implications in cancer[J]. Protein J, 2017, 36(1):1-6. doi: 10.1007/s10930-017-9696-z pmid: 28108801
[7]	Nalefski EA, Falke JJ. The C2 domain calcium-binding motif: Structural and functional diversity[J]. Protein Sci, 1996, 5(12):2375-2390. pmid: 8976547
[8]	Tomsig JL, Creutz CE. Biochemical characterization of copine: A ubiquitous Ca²⁺-dependent, phospholipid-binding protein[J]. Biochemistry, 2000, 39(51):16163-16175. pmid: 11123945
[9]	Perestenko P, Watanabe M, Beusnard-Bee T, et al. The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association[J]. FEBS J, 2015, 282(19):3722-3736. doi: 10.1111/febs.13370 pmid: 26175110
[10]	Seo YM, Park SJ, Lee HK, et al. Copine-7 binds to the cell surface receptor, nucleolin, and regulates ciliogenesis and Dspp expression during odontoblast differentiation[J]. Sci Rep, 2017, 7(1):11283. doi: 10.1038/s41598-017-11641-y
[11]	Park YH, Lee YS, Park JS, et al. Expression of CPNE7 during mouse dentinogenesis[J]. J Mol Histol, 2019, 50(3):179-188. doi: 10.1007/s10735-019-09816-0
[12]	Park SH, Lee YS, Lee DS, et al. CPNE7 induces biological dentin sealing in a dentin hypersensitivity model[J]. J Dent Res, 2019, 98(11):1239-1244. doi: 10.1177/0022034519869577 pmid: 31425664
[13]	MacDougall M, Simmons D, Luan X, et al. Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination[J]. J Biol Chem, 1997, 272(2):835-842. doi: 10.1074/jbc.272.2.835 pmid: 8995371
[14]	Quispe-Salcedo A, Ida-Yonemochi H, Nakatomi M, et al. Expression patterns of nestin and dentin sialoprotein during dentinogenesis in mice[J]. Biomed Res, 2012, 33(2):119-132. doi: 10.2220/biomedres.33.119
[15]	Terling C, Rass A, Mitsiadis TA, et al. Expression of the intermediate filament nestin during rodent tooth development[J]. Int J Dev Biol, 1995, 39(6):947-956. pmid: 8901197
[16]	Park YH, Son C, Seo YM, et al. CPNE7-induced autophagy restores the physiological function of mature odontoblasts[J]. Front Cell Dev Biol, 2021, 9:655498. doi: 10.3389/fcell.2021.655498
[17]	Choung HW, Lee DS, Park YH, et al. The effect of CPNE7 on periodontal regeneration[J]. Connect Tissue Res, 2019, 60(5):419-430. doi: 10.1080/03008207.2019.1574776
[18]	Bai SF, Lee JH, Son C, et al. CPNE7 regenerates periodontal ligament via TAU-mediated alignment and cementum attachment protein-mediated attachment[J]. J Clin Periodontol, 2022, 49(6):609-620. doi: 10.1111/jcpe.v49.6
[19]	Lee D, Park KS, Yoon GJ, et al. Identification of cell-penetrating osteogenic peptide from copine-7 protein and its delivery system for enhanced bone formation[J]. J Biomed Mater Res A, 2019, 107(11):2392-2402. doi: 10.1002/jbm.a.36746 pmid: 31175697
[20]	唐欢, 许海甲, 侯煜东, 等. Runx2基因对骨代谢调控的研究进展[J]. 中国骨质疏松杂志, 2014, 20(12):1501-1505.
[21]	Lee YS, Park YH, Lee DS, et al. Tubular dentin regeneration using a CPNE7-derived functional peptide[J]. Materials (Basel), 2020, 13(20):4618. doi: 10.3390/ma13204618
[22]	Kumar NG, Mehta DS. Short-term assessment of the Nd: YAG laser with and without sodium fluoride varnish in the treatment of dentin hypersensitivity: A clinical and scanning electron microscopy study[J]. J Periodontol, 2005, 76(7):1140-1147. doi: 10.1902/jop.2005.76.7.1140
[23]	Pashley DH, Galloway SE. The effects of oxalate treatment on the smear layer of ground surfaces of human dentine[J]. Arch Oral Biol, 1985, 30(10):731-737. doi: 10.1016/0003-9969(85)90185-2 pmid: 3866520
[24]	Paes Leme AF, dos Santos JCRG, Giannini M, et al. Occlusion of dentin tubules by desensitizing agents[J]. Am J Dent, 2004, 17(5):368-372. pmid: 15575450
[25]	Aminoshariae A, Kulild JC. Current concepts of dentinal hypersensitivity[J]. J Endod, 2021, 47(11):1696-1702. doi: 10.1016/j.joen.2021.07.011 pmid: 34302871
[26]	王鹏义, 宋丽萍, 吴春锋, 等. 治疗牙本质敏感的研究进展[J]. 西南军医, 2020, 22(2):141-144.
[27]	Kim SG. Biological molecules for the regeneration of thepulp-dentin complex[J]. Dent Clin North Am, 2017, 61(1):127-141. doi: 10.1016/j.cden.2016.08.005
[28]	Hosoya A, Nakamura H, Akahane S, et al. Immunohistochemical study of osteodentin in the unerupted rat incisor[J]. J Oral Biosci, 2006, 48(2):132-137. doi: 10.1016/S1349-0079(06)80026-5
[29]	Hahn CL, Best AM. The pulpal origin of immunoglobulins in dentin beneath caries: An immunohistochemical study[J]. J Endod, 2006, 32(3):178-182. doi: 10.1016/j.joen.2005.08.016
[30]	Maita E, Simpson MD, Tao L, et al. Fluid and protein flux across the pulpodentine complex of the dog in vivo[J]. Arch Oral Biol, 1991, 36(2):103-110. pmid: 2059160
[31]	Pashley DH. The influence of dentin permeability and pulpal blood flow on pulpal solute concentrations[J]. J Endod, 1979, 5(12):355-361. doi: 10.1016/S0099-2399(79)80060-6
[32]	Polimeni G, Xiropaidis AV, Wikesjö UME. Biology and principles of periodontal wound healing/regeneration[J]. Periodontol 2000, 2006, 41:30-47. pmid: 16686925
[33]	Ridge SM, Sullivan FJ, Glynn SA. Mesenchymal stem cells: Key players in cancer progression[J]. Mol Cancer, 2017, 16(1):31. doi: 10.1186/s12943-017-0597-8 pmid: 28148268
[34]	Plava J, Cihova M, Burikova M, et al. Permanent pro-tumorigenic shift in adipose tissue-derived mesenchymal stromal cells induced by breast malignancy[J]. Cells, 2020, 9(2):480. doi: 10.3390/cells9020480
[35]	Orciani M, Caffarini M, Lazzarini R, et al. Mesenchymal stem cells from cervix and age: New insights into CIN regression rate[J]. Oxid Med Cell Longev, 2018:1545784.
[36]	Ji XL, Sun TY, Xie S, et al. Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway[J]. Cell Death Discov, 2021, 7(1):294. doi: 10.1038/s41420-021-00684-w pmid: 34650058

Roles of Copine 7 in the development and regeneration of teeth and periodontium

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 2

References 36

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	CHEN Nuo,WEI Yan. Progress in the treatment materials of dentin hypersensitivity [J]. Stomatology, 2023, 43(5): 385-392.
[2]	ZHANG Kaiqi, DONG Jianyong, ZHANG Yajie, HE Yanting, HUO Yuanyuan, LI Zhaoyuan, CUI Jun. An experimental study on the biological characteristics of SDF-1/CS/β-GP composite bio-membrane in vitro [J]. Stomatology, 2023, 43(3): 212-217.
[3]	SHAO Jiaojiao, ZHANG Qi. Application of small molecular compounds in promoting the repair of dentin-pulp complex injury [J]. Stomatology, 2023, 43(3): 256-261.
[4]	WANG Yiyu, HUANG Jiaping, DING Peihui, DONG Yan. Research progress of periodontal tissue regeneration by combined biomaterials of dental derived mesenchymal stem cells [J]. Stomatology, 2023, 43(3): 261-266.
[5]	SUN Jiayao,ZONG Bin,XIE Yutong,XU Quanchen. Cross-regulation of Wnt/β-catenin and NF-κB signaling pathway and their involvement in the differentiation of mesenchymal stem cells [J]. Stomatology, 2023, 43(2): 170-175.
[6]	WANG Ruyu, PAN Yahui, NIE Rongrong, MENG Xiangfeng. Studies on the effect of ultrasound on properties and bonding strength of dentin smear layer [J]. Stomatology, 2023, 43(1): 52-56.
[7]	ZHUANG Qixiang, XIA Yiru, DONG Jiachen, XIE Yufeng, SHU Rong. Effect of recombinant human amelogenin on angiogenesis of human umbilical vein endothelial cell in vitro [J]. Stomatology, 2022, 42(9): 796-801.
[8]	GUAN Yun, YAN Yanhong, SHEN Donghe, JIANG Beizhan. Evaluation of sealing performance of biomimetic mineralized nano-calcium phosphate on dentinal tubules [J]. Stomatology, 2022, 42(5): 411-415.
[9]	ZHANG Yi, ZHAO Bin, WANG Lu, YAO Wei, HAO Fengxiang, YANG Yitian. Progress of research on the application of microspheres in dental tissue regeneration [J]. Stomatology, 2022, 42(4): 362-367.
[10]	FENG Shanshan, JIN Yifu, CHEN Huan, HOU Yanyan, DING Jingyu, ZHU Song. Research progress on the application of antimicrobial peptides in dentin adhesives [J]. Stomatology, 2022, 42(2): 156-159.
[11]	WANG Beibei, HAN Fei, YUAN Xiaojun, CHEN Chen, XIE Haifeng. Effects of myricetin on dentin remineralization and bonding strength [J]. Stomatology, 2022, 42(10): 865-868.
[12]	LIANG Wei, LI Pingping, GE Shaohua. The mechanism and application progress of Nd:YAG laser in the treatment of dentin hypersensitivity [J]. Stomatology, 2022, 42(1): 87-91.
[13]	Xiang LIU. Research progress of the potential use of sitagliptin [J]. , 2021, 41(1): 76-82.
[14]	. Experimental study on the effect of laser combined with potassium fluoride-formaldehyde resin on closing dentinal tubules [J]. , 2020, 40(9): 786-791.
[15]	. Effects of smear layer by different burs on the bonding strength of dentin and self-adhesive resin cement [J]. , 2019, 39(5): 423-426.