非综合征型唇腭裂致病基因及早期诊断研究进展

doi:10.13591/j.cnki.kqyx.2023.08.017

Abstract

Abstract:

Cleft lip and palate (CLP) is one of the most common congenital birth defects. The prevalence of CLP varies among different regions and different populations. The prevalence of CLP is slightly higher in males, and the pathogenesis is complex and still needs in-depth research. The current view is that the combined effect of genetic and environmental factors is the main cause of CLP. In this paper, the research progress of NSCL/P in recent years was summarized in terms of the research methods, pathogenic genes, the correlation between genes and WNT signaling pathways, the interaction between genes and environmental factors, and the early prenatal diagnosis of NSCL/P, so as to provide reference for further research on the etiology and prevention of NSCL/P.

Key words: non-syndromic cleft lip and palate, pathogenic gene, signaling pathway, biomarker

CLC Number:

Dilibaier·YIMINGJIANG , Duolikun·WUFUER . Recent research progress of pathogenic gene and diagnosis of non-syndromic cleft lip and palate[J]. Stomatology, 2023, 43(8): 757-762.

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Recent research progress of pathogenic gene and diagnosis of non-syndromic cleft lip and palate

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