数字化导板引导CGF联合Bio-Oss骨粉充填颌骨囊肿的临床研究

doi:10.13591/j.cnki.kqyx.2023.10.009

Abstract

Abstract:

Objective To investigate the efficacy of digital guide plate guided concentrated growth factor(CGF)combined with Bio-Oss bone powder for filling bone cavity after jaw cyst surgery. Methods Sixty patients who attended the Department of Oral and Maxillofacial Surgery of the Affiliated Stomatological Hospital of Xuzhou Medical University from September 2021 to September 2022 for jaw cyst removal were randomly divided into experimental group, control group 1 and control group 2. In the experimental group, a digital guide was made intraoperatively to locate the cyst and CGF combined with Bio-Oss bone powder was filled into the bone cavity. In the control group 1, a digital guide was made intraoperatively to locate the cyst and Bio-Oss bone powder was filled into the bone cavity, and in the control group 2, Bio-Oss bone powder was filled into bone cavity during the conventional surgery. Preoperative, 24 h and 72 h postoperative blood CRP and WBC levels and the time of surgery were measured. Postoperative pain level was assessed and postoperative bone mineral density values were measured 3 and 6 months after surgery. Results The postoperative CRP and WBC of the three groups were significantly higher than those before surgery. The postoperative inflammatory reaction, operation time and pain level of the experimental group and control group 1 were lower than those of control group 2, and postoperative inflammatory reaction was significantly lower in the experimental group than in control group 1. The bone density of bone defect area of the three groups 3 and 6 months after surgerywas higher than that before surgery, and the experimental group was significantly higher than the other two groups. Conclusion Digital guide plate guided CGF combined with Bio-Oss bone powder to fill the bone defect area after jaw bone cyst removal can shorten operation time, reduce postoperative inflammatory reaction and pain and discomfort, promote bone healing, improve osteogenesis speed and quality, and restore jaw bone morphology faster, which is worth being promoted in clinical application.

Key words: concentrated growth factor, digital positioning guide plate, bone regeneration, bone defect

CLC Number:

R782.4

ZHANG Hao, ZHANG Xinfeng, QI Yuchen, XU Jiabin, SI Yameng. Clinical study on digital guide plate guided CGF combined with Bio-Oss bone powder for filling bone cavity after jaw cyst surgery[J]. Stomatology, 2023, 43(10): 910-914.

Figures/Tables 7

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References 22

[1]	熊贤斌, 吴元元, 郑旸, 等. 颌骨囊性病变囊内压对开窗术后不同时间段体积缩小速度的影响[J]. 口腔医学, 2020, 40(5):411-415.
[2]	Berretta LM, Melo G, Mello FW, et al. Effectiveness of marsupialisation and decompression on the reduction of cystic jaw lesions:A systematic review[J]. Br J Oral MaxillofacSurg, 2021, 59(10):E17-E42.
[3]	王松松, 张云涛, 刘珂珂, 等. 高度浓缩生长因子对MC3T3-E1成骨细胞生物学性能的影响[J]. 上海口腔医学, 2020, 29(5):482-486.
[4]	Lei LH, Yu YY, Han JY, et al. Quantification of growth factors in advanced platelet-rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects[J]. J Periodontol, 2020, 91(4):462-472. doi: 10.1002/JPER.19-0290 pmid: 31471902
[5]	Stanca E, Calabriso N, Giannotti L, et al. Analysis of CGF biomolecules, structure and cell population:Characterization of the stemness features of CGF cells and osteogenic potential[J]. Int J MolSci, 2021, 22(16):8867.
[6]	Ku JK, Han M, Yongvikul A, et al. Volumetric analysis of spontaneous bone healing after jaw cyst enucleation[J]. Sci Rep, 2022, 12(1):14953. doi: 10.1038/s41598-022-16921-w
[7]	Soluk-Tekkesin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions:A Summary of the Changes of the 2022 (5th) Edition[J]. Turk Patoloji Derg, 2022, 38(2):168-184. doi: 10.5146/tjpath.2022.01573 pmid: 35578902
[8]	Melo G, Mello FW, Mesquita RA, et al. Cell-block as ancillary tool for the diagnosis of cystic and cyst-like jaw lesions[J]. Diagn Cytopathol, 2020, 48( 8):717-723. doi: 10.1002/dc.24400 pmid: 32112624
[9]	Koçak E, Yıldız A, Acartürk F, et al. Three dimensional bioprinting technology:Applications in pharmaceutical and biomedical area[J]. Colloids Surf B Biointerfaces, 2021, 197:111396. doi: 10.1016/j.colsurfb.2020.111396
[10]	Tellisi N, Ashammakhi NA, Billi F, et al. Three dimensional printed bone implants in the clinic[J]. J Craniofac Surg, 2018, 29(8):2363-2367. doi: 10.1097/SCS.0000000000004829 pmid: 30277956
[11]	Shi J, Zhou JH, Liu CX, et al. Radiographic bone volume alteration after jaw cyst enucleation with or without simultaneous bone grafts:A prospective randomized study[J]. Clin Implant Dent Relat Res, 2022, 24(4):468-474. doi: 10.1111/cid.v24.4
[12]	Sacher C, Holzinger D, Grogger P, et al. Calculation of postoperative bone healing of cystic lesions of the jaw-A retrospective study[J]. Clin Oral Investig, 2019, 23(11):3951-3957. doi: 10.1007/s00784-019-02826-y
[13]	Stoor P, Apajalahti S, Kontio R. Regeneration of cystic bone cavities and bone defects with bioactive glass S53P4 in the upper and lower jaws[J]. J Craniofac Surg, 2017, 28(5):1197-1205. doi: 10.1097/SCS.0000000000003649 pmid: 28538076
[14]	Raţiu CA, Raţiu IA, Cavalu S, et al. Successful management of spontaneous bone regeneration after jaws cystectomy using PRGF approach; case series[J]. Rom J Morphol Embryol, 2020, 61(3):833-840. doi: 10.47162/RJME.61.3.21 pmid: 33817724
[15]	Feng YJ, Guo WW, Hu L, et al. Application of hydrogels as sustained-release drug carriers in bone defect repair[J]. Polymers, 2022, 14(22):4906. doi: 10.3390/polym14224906
[16]	Dong K, Zhou WJ, Liu ZH, et al. The extract of concentrated growth factor enhances osteogenic activity of osteoblast through PI3K/AKT pathway and promotes bone regeneration in vivo[J]. Int J Implant Dent, 2021, 7(1):70. doi: 10.1186/s40729-021-00357-4 pmid: 34345951
[17]	Qiao J, An N. Effect of concentrated growth factors on function and Wnt3a expression of human periodontal ligament cells in vitro[J]. Platelets, 2017, 28(3):281-286. doi: 10.1080/09537104.2016.1213381
[18]	Qi L, Liu L, Hu Y, et al. Concentrated growth factor promotes gingival regeneration through the AKT/Wnt/β-catenin and YAP signaling pathways[J]. Artif Cells Nanomed Biotechnol, 2020, 48(1):920-932. doi: 10.1080/21691401.2020.1773482 pmid: 32496895
[19]	Firouzi N, Yavari HR, Rahimi S, et al. Concentrated growth factors combined with lipopolysaccharide stimulate the in vitro regenerative and osteogenic activities of human dental pulp stem cells by balancing inflammation[J]. Int J Dent, 2022, 2022:2316666.
[20]	Luo HY, Liu WJ, Zhou YC, et al. Concentrated growth factor regulates the macrophage-mediated immune response[J]. Regen Biomater, 2021, 8(6):rbab049. doi: 10.1093/rb/rbab049
[21]	Nasirzade J, Kargarpour Z, Hasannia S, et al. Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro[J]. J Periodontol, 2020, 91(2):244-252. doi: 10.1002/JPER.19-0216 pmid: 31376159
[22]	Kargarpour Z, Nasirzade J, Panahipour L, et al. Liquid PRF reduces the inflammatory response and osteoclastogenesis in murine macrophages[J]. Front Immunol, 2021, 12:636427. doi: 10.3389/fimmu.2021.636427

分组	年龄/岁	性别		部位		分类
分组	年龄/岁	男	女	上颌骨	下颌骨	根尖囊肿	含牙囊肿	鼻腭囊肿
实验组(n=20)	24.25±3.093	12	8	9	11	16	2	2
对照组1(n=20)	25.00±3.325	10	10	12	8	15	4	1
对照组2(n=20)	25.20±3.071	9	11	13	7	15	2	3
P	0.609	0.627		0.414		0.780

组别	术前1 d	术后24 h	术后72 h
实验组	0.794±0.226	1.068±0.349^ab	3.178±0.281^ab
对照组1	0.778±0.234	1.609±0.768^a	3.495±0.412^a
对照组2	0.780±0.247	2.246±0.538	3.802±0.319
F	0.016	12.515	9.990
P	0.984	<0.001	<0.001

组别	术前1 d	术后24 h	术后72 h
实验组	5.625±0.993	10.724±2.299^ab	6.760±1.614^ab
对照组1	6.198±1.499	13.480±2.167^a	8.887±1.726
对照组2	6.020±1.414	15.563±2.451	9.221±1.260
F	0.592	13.266	8.938
P	0.509	<0.001	0.001

组别	手术时间/min	术后1 d疼痛VAS值	术后3 d疼痛VAS值	术后5 d疼痛VAS值
实验组	54.250±4.070^a	3.583±1.084^ab	1.583±0.793^ab	0.167±0.389
对照组1	52.333±5.123^a	4.667±0.888^a	2.333±0.779	0.417±0.669
对照组2	68.833±5.798	5.500±0.674	2.917±0.669	0.583±0.669
F	38.363	13.759	9.536	1.514
P	<0.001	<0.001	0.001	0.175

组别	术后即刻	术后3个月	术后6个月
实验组	459.89±23.29	659.13±34.76^ab	752.53±40.73^ab
对照组1	458.74±26.64	635.88±31.20	729.03±31.15
对照组2	462.74±21.94	636.97±28.60	726.08±29.20
F	0.147	3.443	3.620
P	0.863	0.039	0.033

Clinical study on digital guide plate guided CGF combined with Bio-Oss bone powder for filling bone cavity after jaw cyst surgery

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