缺氧预处理间充质干细胞来源的外泌体在骨再生中作用的研究进展

doi:10.13591/j.cnki.kqyx.2023.09.014

Abstract

Abstract:

Mesenchymal stem cells have been widely used in regenerative medicine due to their ability of self-renewal, differentiation and immunomodulation. However, the therapeutic effect is limited because of the low survival rate after transplantation and the potential tumorigenicity. Recently many studies have confirmed that the biological function of mesenchymal stem cells is achieved through the release of exosomes and the cell-free therapies based on exosomes have aroused great attention. Furthermore, hypoxia preconditioning can mimic the physiological environment of mesenchymal stem cells, enabling the secreted exosomes to have better bone regeneration capacity. In this review, research advances in the role of exosomes derived from hypoxia preconditioned mesenchymal stem cells in bone regeneration are investigated, and the related mechanisms are discussed. Finally, some problems that need to be noted before clinical application are presented.

Key words: exosomes, bone regeneration, hypoxia preconditioning, vascularization

CLC Number:

R349.8

CAO Ximeng, SHEN Yingyi, XU Chun. Research advances in the role of exosomes derived from hypoxia preconditioned mesenchymal stem cells in bone regeneration[J]. Stomatology, 2023, 43(9): 844-848.

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Research advances in the role of exosomes derived from hypoxia preconditioned mesenchymal stem cells in bone regeneration

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